Sentences with phrase «more telomerase»

In fact, 90 percent of human tumors exhibit more telomerase activity.

In the paper that is now published, they make the stem cells in the bone marrow to produce more telomerase, thus enabling them to repair their excessively shortened telomeres.

Not exact matches

The new research, which studied the immortalization process using genome - engineered cells in culture and also tracked skin cells as they progressed from a mole into a malignant melanoma, suggests that telomerase plays a more complex role in cancer.

The TERT promoter mutation does not generate enough telomerase to immortalize the pre-cancerous cells, but does delay normal cellular aging, Hockemeyer said, allowing more time for additional changes that turns telomerase up.

If the telomeres get shorter, cells get more and more friendly to telomerase.

The scientists speculated that when chromosome tips get too stubby — a process that can be reversed by telomerase, an enzyme made up of protein and RNA — cells cease replicating and enter a state called senescence (see» More Than a Sum of Our Cells»).

Their younger cousins recovered fine, as did older mice with telomerase intact, but more than half of the aged, telomere - depleted mice died from the treatment.

The old, telomerase - deficient mice also had weaker immune systems and had more trouble recovering from a dose of chemotherapy that killed blood cells.

When Lin engineered the telomerase - expressing hepatocytes to die in response to a chemical signal and gave the mice with a liver - damaging chemical, he found that those animals in which the telomerase cells had been killed exhibited much more severe liver scarring than those in which the cells were functional.

Some studies in mice have shown that elevated telomerase activity leaves the animals more susceptible to skin tumors and breast cancer, so maybe there is no free lunch.

Still, BioViva has pressed ahead with telomerase gene therapy, and factions within the research community are also aiming for the same outcome of human tests, though through more conventional channels.

Although we are focused on development in lung cancer at present, AST - VAC2 has potential for broad applications in oncology because telomerase is expressed in more than 95 % of cancers.

Biochemical studies on telomerase for more than two decades have provided a wealth of information regarding telomerase function and substrate specificity.

The enzyme telomerase is present in more than 95 % of all types of human cancers and absent in normal cells in the body.

More than 85 percent of all human cancers have elevated telomerase that propels their growth.

Through such evolutionary processes, a drug that targets telomerase could seem effective at first, only to be defeated by the cancer cell line if it can (for instance) more effectively break the drug down, or prevent the drug from entering its cells, or put out the biological equivalents of the «chaff» and flares that are used by fighter jets to ward off the targeting systems of hostile missiles.