Sentences with phrase «more therapeutic targets»
«The more steps in the mechanism we can understand, the more therapeutic targets we'll find for Alzheimer's disease.»
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The work demonstrates that even with the clinical successes of blocking PD - 1, there may be a better, more refined therapeutic strategy to target the PD - 1 pathway.
The results show TREX2 as a potential therapeutic target to tackle this disease with a different and more focused strategy.
These results should prove useful for setting new therapeutic and preventive targets: «At their parents» request, we also tested the siblings of some of the children carrying the mutation to see if they too are more fragile when it comes to infections.
«Perhaps supplementing the diet of obese pregnant mothers with PQQ, which has proven safe in several human studies, will be a therapeutic target worthy of more study in the battle to reduce the risk of NAFLD in babies,» Jonscher said.
«We wanted to identify some potential therapeutic targets that are common not just to one but to multiple forms of retinitis pigmentosa at late - stage disease, when it is more likely to be clinically diagnosed in a patient population.»
Therefore identifying the essential, tissue - specific effectors of Hh has the potential to lead to the identification of more specific therapeutic targets.
During the last three years the Spanish Consortium for the Study of the Genome of the Chronic Lymphatic Leukemia, where the researchers of the present study already collaborate, has sequenced the genome of hundreds of patients with the more common leukemia in our society, identifying new mechanisms of tumor progression and new therapeutic targets.
«Ultimately, figuring out how to target PC may help researchers develop new, more effective therapeutic strategies to improve upon current lung cancer treatments, which are limited and harmful.»
«Our goal is to learn more about MMP - 9 and related pathways and to identify a new set of therapeutic targets,» said Dr. Henderson.
We've shown it's worth the effort to look into this more deeply, and hopefully what we've done is opened people's eyes to IDE as a valid therapeutic target.»
An emerging controller of the cholinergic effect of inflammation is micro-RNA-132 (5), whose involvement with post-stroke recovery awaits further studies and might open new venues for more rigorous assessment of the post-stroke risk of survival and systematic infection and the identification of conceptually novel targets for therapeutic interference.
«This breakthrough could lead to more effective therapies for women with this very common subtype of breast cancer and be the therapeutic target that the drug companies have been waiting for.»
Most importantly for individuals with FOP, the study identifies HIF - 1α as a therapeutic target — knowledge that will likely contribute to the development of more effective treatments for FOP and related common disorders of heterotopic ossification.
Although far more work needs to be done before bringing it to the clinic, targeting CD146 with AA98, especially in combination with an anti-TNF-alpha antibody, may be a therapeutic option in treating colitis, as well as a preventative method for CAC.»
«This protein is one explanation of why women are relatively protected from type two diabetes, despite having more body fat content compared to men at a given weight,» said Samaan, adding that this is important as it provides a therapeutic target to improve muscle responses to insulin to treat and prevent diabetes.
«With TEK, we know exactly what's going wrong, which means we've identified a pathway that could be a great new therapeutic target for severe glaucoma and even more common forms of the disease.»
«A better understanding of the brain region and cell type - specific binding targets of Hnrnph1 will tell us more about the function of this gene and possibly identify new therapeutic strategies for minimizing risk and treating psychostimulant addiction — a disorder for which there is currently no FDA - approved drug,» explained corresponding author Camron Bryant, PhD, assistant professor of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.
In a new paper published this week in PNAS, researchers describe a potential new class of anti-cancer drugs that inhibit two or more molecular targets at once, maximizing therapeutic efficiency and sa...
It has been suggested that targeting therapeutic interventions to those more likely to develop severe illness and then protecting them from adverse reactions could be useful in pandemic planning [89].
More specifically, he has developed therapeutic approaches that target gene - control mechanisms in the stressed and failing heart, a process that has striking similarities to uncontrolled growth in cancers.
«This project could lead to new therapeutic targets and more effective and safer drugs for the disease.»
Penn Medicine's Hematologic Malignancies Translational Center of Excellence seeks to redefine the diagnostic and therapeutic approach to blood cancers in order to provide more effective targeted therapies.
Examination of such mechanisms by which the brain naturally protects itself may lead to more selective cellular and molecular targets, as well as new therapeutic strategies against brain disease.
Martin Carroll, MD and Edward Stadtmauer, MD are leading efforts at this TCE to redefine the diagnostic and therapeutic approaches to blood cancers — including leukemia, lymphoma and myeloma — and provide more effective targeted therapies.
The Hematologic Malignancies Translational Center of Excellence (TCE) is a multidisciplinary center that seeks to redefine the diagnostic and therapeutic approaches to blood cancers, including leukemia, lymphoma and myeloma, and provide more effective targeted therapies.
A newly - engineered super small Cas9 enzyme could be used to make CRISPR more useful as a therapeutic tool against common and «undruggable» disease targets
Current therapeutic strategies for HD are targeted at decreasing htt protein levels but more research is needed prior to advancing these therapies.
To this end, he has identified and is pursuing new therapeutic targets and experimental strategies to block disease - causing processes and to make the brain more resistant to disease.
«As more of the pieces are assembled, they provide potential new targets for therapeutic agents.»
«This development allows us to study genetic diseases more easily and potentially identify new therapeutic targets.»
It has invested more than $ 450 million in research to date, almost 90 percent for translational research; funded testing of more than 100 therapeutic targets for Parkinson's disease (PD); and has undertaken novel industry partnerships to support early - stage promising therapeutic approaches.
«The combination of a focus on validating new therapeutic targets and mechanisms at CBCS and the more commercial output at SciLifeLab DDD is clearly satisfying both the academic investigator and the industrial partner.»
These proteins, if their roles in neuroprotection in the retina are fully established in the future by more comprehensive studies, may present novel therapeutic targets in treating retinal disorders including glaucomatous conditions.»
But for scientists who develop therapeutic viruses (to, for example, target cancer cells or correct gene deficiencies) a more important question is: How do we keep people's natural immune responses at bay?
Unlike more traditional therapeutic modalities such as small molecules or antibodies, Neurona is focused on unique compositions of cells that can be precisely targeted, integrated into damaged neural circuits, and provide activity - dependent regulation.
So, as modern science discovers more about the therapeutic benefits of camel milk, specific components could be used in a more targeted ways to combat illness.
invest in higher quality support and provide more targeted and therapeutic support to address individual needs.