Sentences with phrase «more tumors in»

Not exact matches

A new study, conducted by the U.S. National Toxicology Program, found that rats consistently exposed to radiofrequency radiation from cellphones were more likely to develop malignant tumors in the brain and heart.

They are finding cancerous tumors that are in phase 0 and 1 in patients who are experiencing no pain, whereas most people are often diagnosed in phase 4, where pain is prevalent and the disease is more difficult to beat.

And using lower levels of Yervoy in combination with Opdivo actually prompted more tumor shrinkage, underscoring the fact that dosing is a critical and unpredictable factor for immunotherapies.

When Jedd Wolchok, a cancer doctor and immunologist leading a Yervoy trial at Memorial Sloan Kettering, examined a melanoma patient's scan 12 weeks after he'd received his course of treatment, the results were utterly disappointing — just like those of any other metastatic patient in the final throes of the disease: The tumors had gotten bigger, and there were more of them.

Patients in the trial had advanced NSCLC, and their tumors tested positive for PD - L1 levels of 50 % or more.

i'm no more bigoted than a surgeon might be in relation to a cancerous tumor — or a gardener in relation to weeds.

Surely, for a patient who can no longer assimilate food, N&H provides no benefit; similarly, some stomach cancer cases result in feeding the tumor instead of the patient; and there are those who are so fragile that almost any invasive insert causes more problems than it relieves.

According to one study, however, cysteine supplementation with whey protein actually lowered levels of glutathione in some tumors, making them more susceptible to chemotherapy.

Topical application of capsaicin on the dorsal skin of 7,12 - dimetylbenz (a) anthracene — initiated and TPA - promoted TRPV1 wild - type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1 / KO mice, suggesting a TRPV1 - independent mechanism.

The study indicated that even a small period of breastfeeding reduces the risk of these stubborn tumors, which are more common in younger women and generally have a poorer prognosis than other subtypes of breast cancer.

The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, in tumor cells.51, 53

«This research represents a big step forward in understanding why some tumors are more aggressive than others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic Cancer Research at MSK, and corresponding author of the companion study in Nature.

«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient's response to therapy.

Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells travel to other parts of the body (metastasize) to find more nourishment.

They discovered that YAP1 is present at higher levels and interacts with OCT4 more in primary and metastatic lung tumors than normal tissue.

«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.

Many more microchimeric cells are found in the blood of healthy women compared to those with breast cancer, for example, suggesting that microchimeric cells can somehow prevent tumor formation.

This additional information will help in the next steps of the research, which involve more detailed study of the PD - 1 at different points in its pathway and with different viral or tumor loads.

In the presence of these drugs tumors grow faster and develop more extensive networks of the blood vessels they rely on to feed their expansion — a process called angiogenesis, says Jonathan Moss, an anesthesiologist at the University of Chicago (U. of C.) Medical Center.

While we observed that biopsies were generally safe and feasible, noninvasive testing methods, such as liquid biopsies that analyze tumor DNA circulating in the patient's blood, may provide another method to more easily characterize resistance over time.»

Additionally, lung cancer patients who have high levels of YAP1 in their tumors are more likely to have a poorer prognosis than patients with low levels of YAP1.

Conventional radiation with photons gave way to intensity - modulated radiation therapy, or IMRT, in which more precise beams of photons could be moved dozens or hundreds of times with varying intensities, attacking tumors in three dimensions with safer high doses.

Conventional, high - dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors» recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

Restoring normal function to a mutated protein is more difficult than simply blocking a protein, the strategy used by most medical therapies, says Klas Wiman, a tumor cell biologist at the Karolinska Institute in Stockholm.

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

While both the ketogenic and modified high - fat, low - carbohydrate diets showed similar effectiveness against tumors in the mouse models, Reynolds said the latter is more nutritionally complete and potentially more appealing to cancer patients because it offers more food choices.

Their analysis of more than 4,000 individual tumor cells, the largest effort to date in brain tumors, finds three developmental categories of cancer cells — one resembling neural stem cells and two characterized by sets of genes indicting paths towards differentiation.

With that knowledge, they screened more than four dozen monoclonal antibodies — unique agents that can stop cells from growing or forming tumors and can be mass produced — before finding two that block tumor creation in both types of cancer.

We found that the inflammation unfortunately gets hijacked by tumor cells that are able to grow faster and penetrate deeper because the blood vessels in the brain are more permeable than in any other part of the body.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

In past imaging studies, my colleagues and I noticed that cervical tumors that took up a lot of glucose prior to radiation treatment tended to be more resistant to radiation therapy than other tumors.

Differences in these processes and their effects on the stomach could help explain why H. pylori is more commonly associated with a cancer type known as gastric adenocarcinoma, while autoimmune disease is linked with neuroendocrine tumors.

Frequent, low - dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the murine study «Metronomic chemotherapy prevents therapy - induced stromal activation and induction of tumor - initiating cells,» which will be published online November 23 in The Journal of Experimental Medicine.

«Different types of cancer cells with different strengths and weaknesses are both present in the tumor at the same time and can work together to spread faster and more efficiently.

With a grant from the Morris Animal Foundation, Antczak, his collaborators Samantha Brooks and Ann Staiger from the University of Florida, and the rest of the team applied a genomewide association study to compare the genetic makeup of horses with and without sarcoid tumors at more than 50,000 sites in the equine genome.

«If we could load these virus shells with a different cargo, say a drug, and target it to a particular place in the body, such as a tumor, it could then deliver the drug to just that specific location, making the drug more effective, or reducing side effects,» Lawrence said.

The African American mRNA variants encode protein isoforms that make a tumor more aggressive, whereas the protein isoforms generated in European Americans appear to make the tumor less aggressive.

In some horses, tumors develop as small bumps under the skin or as scaly lesions that easily can be removed by a veterinarian, but in other horses the problem becomes much more seriouIn some horses, tumors develop as small bumps under the skin or as scaly lesions that easily can be removed by a veterinarian, but in other horses the problem becomes much more seriouin other horses the problem becomes much more serious.

In contrast, our blood - based test is minimally invasive, inexpensive, and more sensitive, thus suitable for large population screening to detect early - stage tumors.»

According to follow - up reports, Zola remained well for eight more years before dying from a recurrence of the tumor in his native Italy.

The researchers «deserve a lot of credit» for testing the approach in the mice that spontaneously develop breast tumors, he says, which more closely mimic how cancer arises in humans.

«This shows that the nanoparticle - encapsulated drug is more effective in tumor reduction than the drug alone in these animal models,» says Le.

As new oncogenic driver genes are identified, the testing process becomes less efficient because more genes need to be analyzed in limited amounts of tumor tissue.

More recently, the peptide has become the key ingredient in an experimental surgical tool called Tumor Paint.

These might make a cell hardier in a foreign environment — say, when a breast cell relocates to bone — or more able to escape the primary tumor and survive while rushed through the bloodstream.

Then Hamede Ross saw something even more remarkable: In five devils, the tumors got smaller and went away.

Cells suspended in a stiff matrix were more likely to work their way through the matrix to other side of a serum gradient, analogous to how metastasizing cancer cells break free from their tumors.

In other words, regardless of surgery timing, patients who require higher risk procedures, such as a major liver resection due to the presence of larger or multiple metastatic tumors or high - risk colorectal resections, have poorer outcomes than those who underwent more minor surgery.