Sentences with phrase «more uncertain results»

But that can be difficult and even dangerous work, often with much weaker and more uncertain results.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Moreover, our international expansion efforts have resulted and will continue to result in increased costs and are subject to a variety of risks, including increased competition, uncertain enforcement of our intellectual property rights, more complex distribution logistics, and the complexity of compliance with foreign laws and regulations.

Mathematics is ordinarily considered as producing precise and dependable results; but in the stock market the more elaborate and abstruse the mathematics the more uncertain and speculative are the conclusions we draw therefrom.

Finally, preoccupation with the fascinations of progressive scientific discovery and with the material products of technology has turned man's attention away from the more uncertain and outwardly less rewarding results of the religious life.

Football like life is uncertain... What is certain however is that following the same failed strategy year after year and expecting a different result is a sign of ineptitude if not madness... Our best 11 ain't up to it largely because it doesn't threaten and unthreatened teams also mean there is more pressure on our defence as well... So a bit of tinkering in the middle of park ain't going to deliver titles that is for sure... Draxler plus a mobile striker is needed... So unless the idiote grenouille is willing to shelve out 80m can kiss titles goodbye now... He can recover 30 - 40m with obvious sales of mediocre attacking options so not too onerous but at this rate it's déjà vu all over again

Ory said of the more than 5,000 samples they tested, only one required the longer test to clarify an uncertain result.

Those pollsters who do seek a more thorough understanding of public attitudes find a marked lack of knowledge of the basic facts and even an acknowledgment of that ignorance — resulting in uncertain and highly malleable opinions.

More experienced surgeons were less likely to overreact, but even one out of four doctors in that group said they would treat uncertain results the same as a BRCA mutation.

They picked problems of practice for which a positive result was virtually guaranteed rather than difficult challenges with more uncertain outcomes.

Cloud responses are more uncertain and that feeds in to the uncertainty in overall climate sensitivity — but the range in the AR4 models (2.1 to 4.5 deg C for 2xCO2) can't yet be constrained by paleo - climate results which have their own uncertainties.

Some of the problems are the same which Gavin mentioned in his reply to 46 above (Mixing of Cloud Radiative Forcing and TOA radiative forcing, uncertain CRF before 1950) but there are many more (e.g. a lot of necessary assumptions to get to the result, etc.).

The precise magnitude of the anthropogenic contribution remains uncertain, but in nine out of ten cases our model results indicate that twentieth - century anthropogenic greenhouse gas emissions increased the risk of floods occurring in England and Wales in autumn 2000 by more than 20 %, and in two out of three cases by more than 90 %.

What is the resulting policy decision should weigh the available information more widely taking many other — mostly again uncertain — factors into account as well.

It seems that the more missions are added to the melting pot, the more uncertain the altimetric sea level change results become.

As I might put it plainly, inappropriate validation metrics were used, so the results of the reconstruction are far more uncertain than claimed.

The impact of internal variability of the AMOC on the ITCZ is more uncertain, but there are interesting recent results, including high predictability of shifts in the ITCZ position (Martin and Thorncroft 2015), which seem to be related to changes in the AMOC in the subpolar North Atlantic.

Why isn't a TCR type of simulation, but instead using actual history and 200 year projected GHG levels in the atmosphere, that would produce results similar to a TCR simulation (at least for the AGW temp increase that would occur when the CO2 level is doubled) and would result in much less uncertainty than ECS (as assessed by climate model dispersions), a more appropriate metric for a 300 year forecast, since it takes the climate more than 1000 years to equilibrate to the hypothesized ECS value, and we have only uncertain methods to check the computed ECS value with actual physical data?

We have more confidence in our present - day (interglacial) result since it is based on fits to direct observations rather than on more uncertain paleoreconstructions, and we find it unlikely that glacial sensitivities were much lower than 2.5 K, given ice albedo feedbacks (47, 48).

So we have the first weird result that the more uncertain the models are, the more action is needed.