«Our aim was to identify what changes in
a mosquito during infection, so that we can target those pathways and block them to prevent transmission of these mosquito - borne viruses,» said Rushika Perera, assistant professor in the Department of Microbiology, Immunology, and Pathology at CSU.
Not exact matches
The researchers used mice that were susceptible to DENV
infection via the skin and inoculated amounts of virus and saliva thought to resemble actual amounts transferred
during a
mosquito bite.
Following transmission by
mosquitoes, the early specific (also called adaptive) immune response to WNV is thought to be dominated by antibodies, and, consistent with this, the researchers found that older mice had less potent WNV - specific antibody responses
during the early phase of
infection.
In many areas of the world, dengue has now become endemic, meaning that the virus exists at low levels year - round, and
infections occur annually
during the rainy season when
mosquito populations increase rapidly.
By integrating the sequence data and the associated metadata, we have established laboratory and bioinformatics - based methods that enable us to investigate scientific questions including: the tropism of ZIKV for dendritic cells and the antiviral response of the cells
during infection (Bowen et al. 2017); investigating the phylogenetic diversity of strains obtained by Biodefense and Emerging
Infections (BEI) Resources and distributed to virologists (manuscript in preparation); the genetic determinants of ZIKV host adaptation in C6 / 36
mosquito vs. Vero cells; and the diversity of ZIKV circulating in limited geographic regions, including Barbados, Colombia, and the state of Chiapas, Mexico.
Flooding throughout much of the nation
during the first half of 2003 led to increased risk of exposure and
mosquito - transmitted
infection.
Even though the chance of
infection is lower
during the winter months, it only takes one
mosquito to cause this deadly disease, and if one gets in the house this could be enough to cause a problem.
Dogs may be bitten by a
mosquito during the summer and not reveal
infection for up to six - and - a-half months.