Sentences with phrase «most common alleles»

The two most common alleles in the Add Health sample were the 4 - repeat and the 7 - repeat.

The TAS2R8 gene's two most common alleles are for tasting and nontasting.

Not exact matches

Until recently, half of the human race died from infectious causes before adulthood, providing strong selective pressure for genetic alleles that enhance host defence but why are the genetic alleles that are most frequently associated with depression so common in the modern gene pool?

His group has found, for example, that APOE3 — by far the most common APOE allele in humans — is usually inherited either with a short or a very long 523 tract.

The most parsimonious explanation is that these alleles represent the ancestral human condition, inherited by both Neandertals and modern humans in Africa from their common ancestor, Capra says.

Of the nearly 50,000 modified cxcr4 alleles analyzed across five independent experiments, 81.1 % (range 75.3 — 81.7 %) contained pure deletions from 1 — 64 bp in size with the most common deletions being 2, 9, 12, 15, 18, and 25 bp, while 13.5 % (range 12.8 — 16.9 %) of cxcr4 alleles contained pure insertions ranging from 1 to 69 bp with more than 90 % being 7 bp or less (Figure 1B).

Not so long ago, there was a hope in the research community that common genetic variation, i.e. variants present at minor allele frequencies > 5 % in human populations, might explain most or all of the heritability of common complex disease.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

In contrast, more than 70 other common alleles have been associated with breast cancer susceptibility, most of which confer only a mild to moderate increase in risk.

The benefit seemed to be particularly pronounced in individuals with the apolipoprotein E-e4 allele, a genetic marker associated with late - onset Alzheimer's, which usually happens after the age of 65, and is the most common type of the disease

Although the newest edition of the authoritative textbook, Vitamin D, claims that in humans calcidiol binds with equal affinity to the DBP whether it is derived from vitamin D2 or vitamin D3, 37 the citation for this statement is the author's own PhD thesis, in which he reported results obtained from testing the DBP of a mere two people.48 Since the gene for the DBP is one of the most polymorphic known (meaning it exists in many forms), existing in three common alleles and 124 known rarer alleles (alleles are specific forms of the same gene), each allele itself having many polymorphisms, 37 a sample size of two is rather unconvincing.

The traditional color, produced when one or both genes have the dominant allele, is commonly referred to as black or black and rust (also called black and tan), while the most common variation, due to both genes having the recessive allele, produces what is called a red or red and rust Doberman in America and a «brown» Doberman in the rest of the world, which is primarily deep reddish - brown with rust markings.