Sentences with phrase «most difficult sides»

This said, clubs who want to challenge for the top four do need players who can pick off the teams in the lower parts of the table, as they can sometimes be the most difficult sides to break down.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

I stressed that the adjustment was going to be far more difficult than what they were hearing from sell - side analysts, most of who had only just woken up to the realization that there been a great deal of investment misallocation in China.

And that's not only in the US, that's in Europe in particular, certainly in the UK, and it's difficult I think to have a certainty around it but I think our bias is that bonds are on the expensive side at the moment and we are generally in most developed markets running shy of benchmark duration positions.

Precisely when time is most on your side is when it's most difficult to think about the future, routinely save and invest, and have the patience to see these things out.

To argue by inference from effect to Cause, from the passive object to the active Subject of change, from transitory, contingent being to a Being who is necessary and eternal, from nature's striving after perfection to a Perfection which is ultimate, from the order observable in creation to a creative Mind - all that (I shall be told) is to approach the great Riddle from one side, and that the most difficult.

It is here that the profound issues at stake, which are more difficult to specify than knee - jerk polemicists on either side often assume, come most clearly into view.

It is particularly difficult for strikers to break through the ranks into the first - team at the bigger clubs at present, with most sides opting to play only one striker in the starting XI, and Arsenal is no different on that front.

Arsenal are the only side in the league averaging over 20 shots per game, in fact Ozil, Ramsey and Cazorla alone have created 60 chances, now of those 60 chances, it is only probably the most difficult that has been converted, Olivier Girouds fantastic Volley Vs Palace.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

If he could play like this most of the time, Mustafi would have a difficult time getting back into the side.

PSG are undergoing pressure to sell some of their higher quality stars in order to comply with FFP, with the French side looking to offload stars Lucas Moura, Julain Draxler and Angel Di Maria in January in order to raise funds, report the Daily Mail, however selling Cavani may be the most difficult of all.

Speaking to the media, Bayern's head coach, Pep Guardiola, admitted that his side will most likely face a very difficult game as Roma are strong and play excellent football.

I've seen three home games now in this league and this was perhaps the most difficult of the three, although a very big athletic Millwall side caused some problems.

The 20 - year - old was highly - rated following an impressive campaign at Sporting Gijon, but despite being Betis» most expensive signing, he has found it extremely difficult to dislodge the free - scoring veteran, Ruben Castro, from the side.

But even Blackpool, who have scored more than the likes of Liverpool, Everton and Tuesday's opponent's Sunderland, aren't necessairly entitled to goals and, just like Sunderland, will contest one of their most difficult fixtures of the year, possibly even campaign, against a Sunderland side who have been sublime in their own backyard and have conceded in just one of their previous six matches on Wearside.

Parents love the adjustable side impact protection; it passes the most difficult tests.

So if your mom is great at uplifting, supportive talk, she might be a helpful person to be by your side when you go through possibly one of the most difficult experiences of your life.

I was one of the most difficult baby objects to put together but, that's a side note but, anyways, what are some ways that we can dispose all our diapers?

Most babies will prefer the side with more milk unless engorgement makes it too difficult for the baby to latch.

All marginals are close and difficult to predict, but the perfect storm of two sides» acrimony and voters» failure to pick a clear winner made this one of the most compelling.

governors races are up — and an amazing 22 of them are open seats — that sort of volatility makes choosing the 15 races most likely to switch sides this fall a difficult chore.

Current treatment strategies (most often long - term steroid use) are plagued by difficult side effects and fail to target an underlying source of the disease.

HLHS is one of the most complex heart defects to treat because most of the structures on the left side of the heart are too small and underdeveloped — or hypoplastic — and it is difficult for the heart to provide enough red blood flow for the body's needs.

But despite their good prognosis, many patients» powerful gut responses to their diagnosis (and the overall threat of cancer) drive their preferences for the most aggressive treatment strategies — overtreatment that could have incumbent side effects, additional risks or more difficult recovery.

This method destroys most (but not all) of the anti-nutrients but has the unhappy side effect of so denaturing the proteins that they become very difficult to digest and much reduced in effectiveness.12 The phytate content remains in soy milk to block the uptake of essential minerals.

This process removes most — but not all — of the trypsin inhibitors, but has the unfortunate side effect of over-denaturing the other proteins in soy, particularly lysine, rendering them difficult to digest and possibly toxic.

Once you become more comfortable you can move the arms out to the sides or all the way forward (most difficult).

The actor, likely best known for his role as Debra Messing's son on the TV series «Smash,» says the most difficult part was capturing the reckless side of Casper — but that was also what drew him to the role.

The side content is the collectibles and it is the part which carries the most difficult tasks and platforming sequences.

Once people start creating levels it will no doubt launch a whole community challenging each other with some of the most difficult and unique side scrolling action ever seen.

Above all else, I learned how challenging — and rewarding — it is to take your passion and skills and direct them towards the most difficult challenges we face in our nation and to do this important work side by side with incredibly talented and committed people and in partnership with underserved students, families, and communities.

The small overlap frontal test is considered one of the most difficult tests, as it challenges the airbags and safety belt to guard a person moving forward and to the side when the car hits an obstacle head on with 25 % of the vehicle.

With 755 horsepower the 2019 Chevrolet Corvette zr1 is the most powerful Corvette ever it's also the most technologically advanced behind me are the rolling s's at Road Atlanta and we're here to see if we can reach to the supercar levels of performance afforded by this thing's massive power big tires and the tall wing on the back after that we'll take to the streets to see if a car this powerful can behave itself in public this is a monster of a car I've had some brief track opportunities moving this morning to get used to the pace of this machine which is phenomenal we're gonna warm up as we get out to the road Atlanta and sort of build up to the pace that this car can operate at now initially when you hop in this car you have this shrine to the engine right above you you see the line of the hood it kind of dominates the center of the view you can see over it it doesn't affect visibility but it's immediately obvious and that kind of speaks to what makes this car special it's a monster of an engine listen to that [Music] that is tremendous tremendous acceleration and incredible power but what I finding so far my brief time here at the Atlanta is that everything else in the car is rut has risen to match hurt me while I lay into it on the back straight look you know 150 mile - an - hour indicated we're going to ease up a little bit on it because I need to focus on talking rather than driving but like I was saying the attributes of the rest of the car the steering the braking capability the grip every system of this car is riding to the same level of the power and I think that's what makes it really impressive initially this is undoubtedly a mega mega fast car but it's one that doesn't terrify you with its performance potential there's a level of electronic sophistication that is unparalleled at this price point but it's hard not to get you know totally slipped away by the power of this engine so that's why I keep coming back to it this car has an electronically controlled limited slip differential it has shocks filled with magnetically responsive fluid that can react faster to inputs and everything this car has a super sophisticated stability control system that teaches you how to drive it quick but also makes you go faster we haven't even gotten into exploring it yet because the limits of this car are so high that frankly it takes a while to grow into it but [Music] I think what's impressive about this car is despite how fast it is it is approachable you can buy this car to track dates with it and grow with it as a driver and as an owner I think that's a really special [Music] because you will never be more talented than this car is fast ever unless you are a racing driver casually grazing under 50 miles an hour on this straight okay I'm just going to enjoy driving this now [Music][Applause][Music] this particular Corvette zr1 comes with the cars track performance package a lot of those changes happen underneath the sheet metal but one of the big differences that is immediately obvious is this giant carbon fiber wing now the way this thing is mounted is actually into the structure of the vehicle and it makes you know loading the rear hatch a bit more difficult but we're assuming that's okay if you're looking for the track performance this thing delivers also giving you that performance are these Michelin Pilot Sport cup tires which are basically track oriented tires that you can drive on the street but as we wake our way to the front of the thing what really matters is what's under the hood that's right there's actually a hole in the hood of this thing and that's because this engine is so tall it's tall because it has a larger supercharger and a bunch of added cooling on it to help it you know keep at the right temperature the supercharger is way larger than the one on the zo six and it has a more cooling capacity and the downside is it's taller so it pops literally through the hood the cool thing is from the top you can actually see this shake when you're looking at it from you know a camera from the top of the vehicle this all makes for 755 horsepower making this the most powerful Corvette ever now what's important about that is this not just the power but likewise everything in the car has to be built to accommodate and be able to drive to the level of speed this thing can develop that's why you had the massive cooling so I had the aerodynamics and that's why I had the electronic sophistication inside [Applause] we had a lot of time to take this car on the track yesterday and I've had the night to think about things Matt today two crews on the road and see how this extreme performance machine deals with the sort of more civil minded stuff of street driving the track impressions remain this thing is unquestionably one of the most capable cars you can get from a dealer these days a lot of that's besides the point now because we're on the street we have speed limits they have the ever - present threat of law enforcement around every corner so the question is what does this car feel like in public when you slow this car down it feels like a more powerful Corvette you don't get much tram lining from these big wheels though we as the front end doesn't want to follow grooves in the pavement it is louder it is a little firmer but it's certainly livable on a day to day basis that's surprising for a vehicle of this capability normally these track oriented cars are so hardcore that you wouldn't want to drive them to the racetrack but let's face it you spend more time driving to the track than you do on the track and the fact that this thing works well in both disciplines is really impressive I can also dial everything back and cruise and not feel like I'm getting punished for driving a hardcore track machine that's a that's a really nice accomplishment that's something that you won't find in cars that are this fast and costs maybe double this much the engine in this car dominates the entire experience you can't miss the engine and the whole friend this car is sort of a shrine to it the way it pops out of the hood the way it's covered with coolers around the sides it is the experience of this car and that does make driving this thing special and also the fact that it doesn't look half bad either in fact I think it has some of the coolest looking wheels currently available on a new car this car as we mentioned this car has the track package the track package on this car gives you what they call competition bucket seats which are a little wide for my tastes but I'm you know not the widest person in the world this automatic transmission works well I mean there's so much torque again out of this engine that it can be very smooth and almost imperceptible its clunky on occasion I think I'd might opt for the manual although Chevy tells me about 80 % of its customers will go for the automatic I don't think they're gonna be disappointed and that's gonna be the faster transmission drag strip on the street - and on the racetrack man it was a little bit more satisfying to my taste though we've talked about the exhaust I have it set in the track setting let's quiet it down a little bit so you can hear the difference now I've set that separately from everything else so let's put it stealth what happened to the engine sound that's pretty that's pretty amazing man stealth is really stealth and then go back to track Wow actually a really big difference that's that's pretty great the Corvette has always been a strong value proposition and nowhere is that more evident than this zr1 giving you a nearly unbeatable track performance per dollar now the nice thing is on the road this doesn't feel like a ragged edge track machine either you could genuinely drive it every day the compromises are few and that's what makes this car so special if you like what you see keep it tuned right here and be sure to visit Edmunds.com [Music]

But worldwide bear markets present difficult conditions for most short - side participants.

As a contrarian, I want to be trading when most other retail traders are committed to the wrong side of the market, and this is difficult to do if you don't understand false - breaks and fakey patterns.

For example, most stock markets have a bullish bias, this means traders tend to like the long side or upside of the market more and as a result of this it is actually more difficult and generally requires more margin to sell short in a stock market.

One of the most important things you can do is to put him on a weight loss diet as any extra weight would add extra stress to breathing; you should be keeping him on the lean side which I know can be difficult in cases of injury.

On top of that, AVDC claims that it's quite impossible to evaluate the overall oral health status of the non-anesthetized dog, and most of all, it would be very difficult to scale hard - to - reach areas, such as the inner sides of the teeth and the deeper subgingival area in a non-anesthetized dog.

Aonang Villa Resort enjoys one of the best locations possible: right on the beach in the most popular holiday resort in southern Thailands Krabi Province, its difficult to make it better.Standard, Superior (with or without sea view), Deluxe Lanai, Junior Suite, and Handicap are the seven room types available in the hotel: from 36.5 sqm (Standard) to 78sqm (Junior Suite) all rooms feature the following amenities: air conditioning, room safe, mini-bar, satellite television and a spacious private balcony.On the facilities side, Aonang Villa Resort has it all: two large freeform swimming pools (including childrens pool), fitness centre with cardiovascular and workout equipment, a games room with table tennis and pool tables, and a Kids Club offering a wide range of exciting educational activities for your little ones.

Further down the road near Devil's Elbow just before Lorne is a rest stop where you can bask in the knowledge you have completed the most difficult part of the drive — a single laned road with cliffs to one side and the ocean on the other — and looking onwards into the dense treetops of one of the many National parks.

While the current release of the port is still considered a work in progress, it has been noted that the controls are a little bit on the difficult yet tricky side, however that would most likely be fixable in a future release.

Robert's Picks: Having to side with either Assassin's Creed III or Need for Speed: Most Wanted might be one of the season's more difficult dilemmas.

The story unspools over the course of one of the most adorable games to debut this season, giving the Wii a unique old fashioned 2D side - scrolling platformer that can be as easy or as difficult as one wants to make it.

Most of the information is in the «Path» section which is a little difficult to find - the link is in the middle of the field emblem on the right hand side of the main screen.

And on the economic side, which is more difficult and gnarly, there's no such thing as peer reviewed data in most cases.

It's difficult for guys like us to see the other side because it doesn't occur to most of us to even ask the right questions.

While you focus on recovery, we will handle all aspects of your case and remain at your side during the most difficult time of your life.

You may likely be going through one of the most difficult times in your life, but we could advise you, represent you, and stay by your side every step of the way.

He is never phased by the other side, and has an excellent manner with even the most difficult clients.