Sentences with phrase «most genes involved»

Most genes involved in the regulation of the circadian clock have been characterized, but Akihiro Goriki, Toru Takumi and their colleagues from RIKEN and Hiroshima University in Japan and University of Michigan in the United States knew that a key component was missing and sough to uncover it in mammals.

According to a study published on the journal Molecular Biology and Evolution, most genes involved in complex processes are present in sponges.

Not exact matches

But still most people would tend to agree that a program of controlled eugenics that involved exterminating humans with defective genes is immoral even though it could accelerate evolution an better the species.

Genetic variations most strongly associated with high scores were found near the GATA2 gene — involved in the development of inner ear hair cells and the inferior colliculus.

They found that a group of genes in the nucleus accumbens — an area involved in creating pleasurable feelings — were expressed most strongly in their group of alcoholic smokers (Alcoholism: Clinical and Experimental Research, DOI: 10.1111/j.1530-0277.2010.01207.x).

One of the genes most often associated with anorexia nervosa codes for BDNF, a factor involved in neuron survival and neuroplasticity.

Most divergence between breeds, however, involves many genes, unwittingly selected by breeders aiming to refine the characteristics of particular lineages.

Most of the genes are involved in cells» ability to deal with oxidative stress, in which reactive oxygen products of metabolism harm cells.

They then used a genetic technique called quantitative trait locus analysis to search for the genes involved in generating phenolics in the most promising progeny.

The most striking pattern was that 147 genes involved in the immune system made it more reactive or «pro-inflammatory» during winter or rainy seasons (Nature Communications, DOI: 10.1038 / ncomms8000).

Tallying the genes that were most perturbed by loss of Lef1 in this brain region revealed that over 20 were involved in mood disorders like depression and anxiety.

Several factors have been implicated in Alzheimer's, including the build - up of an abnormal protein called beta amyloid, fibrous tangles in the brain involving abnormal forms of a protein called tau, and — most recently — an association between the disease and a gene called ApoE.

Ten percent of cases are inherited; most involve unidentified genes.

Scientists knew Apc was involved in stifling tumor formation because most colon cancers find a way to turn the gene off.

«The call of the sea: Mammalian evolutionary transitions back to the sea: Hundreds of genes involving smell, taste, skin, muscle and metabolism most affected.»

Instead, a chromosomal region containing genes involved in neuronal development explained most of the male behavioural response.

To begin to grapple with those questions, the researchers involved in the new study first selected as «seeds» the nine genes that have been most strongly tied to ASDs in recent sequencing research from their labs and others.

In 1993, Poirier and his Montreal - based team co-discovered an important genetic risk factor involved in the most common form of the disease: a defective gene, called Apolipoprotein E type 4 (ApoE4), that prevents the normal transport of cholesterol and phospholipids to the brain.

«Twin studies are one of the most important pieces of evidence for genes being involved [in autism],» says Abha Gupta, a pediatrician who also researches the genetics and neurobiology of ASD at Yale School of Medicine.

Hybrid sterility is due to genes, but because most species can not be crossed it is hard to find out which ones are involved.

Patterns of genetic variation along the genome also revealed a total of 121 genes selected by Scythian breeders, most of which are involved in the development of forelimbs.

«The most intriguing of these genes is FGFRL1, which has a cluster of amino acid substitutions unique to giraffe that are located in the part of the protein that binds fibroblast growth factors — a family of regulators involved in regulating many processes including embryo development,» Cavener said.

A comprehensive genomic analysis of Wilms tumor — the most common kidney cancer in children — found genetic mutations involving a large number of genes that fall into two major categories.

Although the majority of genes related to energy production, cell division, and metabolism in M. jannaschii are most similar to those found in Bacteria, most of the genes involved in transcription, translation, and replication in M. jannaschii are more similar to those found in Eukaryotes.

It is particularly useful when clinicians want to identify an illness or gene mutation involving a single patient or the patient and two or three other family members, which is the most common clinical situation for undiagnosed diseases.

The discovery was made during an analysis of the parasitic plant Viscum scurruloideum, a species of mistletoe whose apparent ability to survive and thrive without several genes involved in the primary energy - producing pathway of oxygen - respiring organisms could make it one of the most unusual plants on Earth.

His symptoms may come closer to mimicking the human disease than most mouse models of mental illness, because the gene involved has such a powerful effect.

«The most exciting thing about our study is not that we've identified a new gene involved in pulmonary hypertension, but that we've found a drug that can «rescue» some mutations,» said co-senior author Wendy K. Chung, MD, PhD, associate professor of pediatrics and medicine at CUMC.

Genetic studies have turned up several genes that appear to predispose for IBD, most of them involved in the body's immune response.

But most of our 23,000 genes are involved in fundamental processes such as cell division, and do not have any known effects on our character.

Instead, a chromosomal region containing genes involved in neuronal development explained most of the male behavioral response.

One of the most cited examples is the mutation involved in lactose tolerance, which is also caused by regulation from outside the gene.

But when BRCA1 was first discovered (This Week, 24 September 1994), most scientists expected that the gene would also be involved in many sporadic tumours.

They found that a group of genes in the nucleus accumbens — an area involved in creating pleasurable feelings — were expressed most strongly in their group of alcoholic smokers (Alcoholism: Clinical and...

In CF a defect in a gene for a transporter protein involved in mucus production affects many organs and tissues, but its most serious effects are often seen in the lungs.

«Understanding which genes are involved in transgenerational acclimation, and how their expression is regulated, will improve our understanding of adaptive responses to rapid environmental change and help identify which species are most at risk from climate change and which species are more tolerant,» Dr Veilleux says.

The team of Luis Lopez - Molina, professor at the Department of Botany and Plant Biology of UNIGE's Faculty of Science, Switzerland, has been interested for a long time in the mechanisms controlling germination, arguably the most critical decision in the life of a plant: «We have discovered that the genes involved in the synthesis of cutin, a waterproof substance, are important for the maintenance of dormancy in seeds of Arabidopsis thaliana, a small plant widely used as a model organism to study plant biology.

Most analytical approaches to this problem are rather rudimentary and involve calculating simple correlations among the genes whose expression changes in response to a perturbation, clustering the genes by molecular or known functional class, and drawing crude inferences about mechanism on that basis.

Most strikingly, the warmest soil sample in Jansson's study — the spongy bog soil — revealed an array of microbial genes and proteins involved in the production of methane, a greenhouse gas more than 20 times as potent as carbon dioxide.

The most common fusion they observed involved the genes FGFR (fibroblast growth factor receptor) and TACC (transforming acidic coiled - coil).

The most important genes involved are BRCA1 and BRCA2, discovered in the mid-1990s.

«What was most surprising was what processes those genes were involved in.»

Two alpha globin genes, HBA1 and HBA2, involved in the transport of oxygen from the lung to the peripheral tissues, show an increased expression in several tissues but not in blood, where they are the most expressed genes (Fig. 2d).

In addition, analysis of the microarray results obtained with RNA from the optimized protocol showed that, as expected, the genes involved in methane production (methanogenesis) were among the most highly expressed genes in M. barkeri.

UM270 was the only strain possessing genes involved in the synthesis of indole -3-acetic acid (IAA), the most common auxin, and phenylacetic acid (PAA), also known for its antimicrobial activity (23).

Most biological traits involve many, many gene - products playing hyper - complex, interdependent, non-additive roles via long intricate processes.

Most biological traits involve many, many gene - products playing hyper - complex, interdependent, non-additive roles via long intricate

Although most adult leukemias involving MLL affect a different part of the gene, the breakpoints found in infant leukemias and secondary leukemias occur predominantly in the small region altered by the bioflavonoids.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

The three most common combinations of molecular diagnoses involved autosomal dominant disease genes: