Sentences with phrase «most potent»

Next, the researchers use two checkpoint inhibitors — the monoclonal antibodies anti-CTLA4 and anti-PD-L1, the most potent immunotherapy currently available — to treat the mice with cancers.

The most potent of these, known as effector memory T cells, are activated by a group of proteins known as human leukocyte antigens (HLAs) on the surface of endothelial cells lining the donated organ's blood vessels.

In a recent paper in The Journal of Biological Chemistry, researchers at Yale University and Queen's University reported the crystal structure of the most potent antifreeze protein known — RiAFP, found in a longhorned beetle.

The particle has been hypothesized for decades, and was finally discovered two years ago using the Large Hadron Collider, the most potent particle accelerator in the world.

(S)-42 was identified as the most potent compound [IC50 -LRB-(S)-42) = 1.2 μM].

Already, Graham said, VRC researchers have shown that passive immunization with VRC01, one of the broadest and most potent bNAbs identified in recent years, can protect rhesus macaques from virus challenge, adding that VRC01 is now ready to be used in human trials.

Hookipa's TheraT ® platform is based on an attenuated replicating virus and is capable of eliciting the most potent T cell responses — a crucial step in treating patients with aggressive cancers.

Replacement of the side chain with an isopropyl group led to the most potent compound 88, showing an IC50 of 2 nM for antiviral activity and suitable pharmacokinetic properties.

Nal - Gly modification resulted in the most potent inhibitors (10 and 11) of this series of compounds, suggesting that the amidine substructure is more appropriate than the compact amide scaffold.

By extending the coherence time of electron states to over half a second, a team of scientists from Berkeley Lab, UC Berkeley, and Harvard University has vastly improved the performance of one of the most potent possible sensors of magnetic fields on the nanoscale — a diamond defect no bigger than a pair of atoms, called a nitrogen vacancy (NV) center.

Testing for anti-HIV activity showed that the cis analogue 76a (anti-HIV IC50 = 35 nM), comparable with bicyclic tetrahydroquinoline derivative 75, was the most potent among the isomers, while the activities of the cis isomer 76b and both trans diastereomers 76c and 76d were more than 10-fold lower.

«Aflatoxin is one of the most potent toxins on the planet,» says Monica Schmidt, lead researcher on the study.

TNF is one of the most potent effector cytokines in the pathogenesis of autoimmune disorders, and blockade of TNF with anti-TNF antibodies is an effective treatment for many patients with IBD.

The most potent modifier was the import factor, transportin - 1.

A critical implication of this work for the field of HIV vaccine design is the observation that the most potent and broad individual anti-HIV VHH, J3, was elicited in response to the gp140 immunogens used.

This particular type of bnAb is among the most potent, or effective neutralizers of HIV.

The dermis contains copious numbers of cutaneous dendritic cells that are important for an intradermal route of immunization.10 Dendritic cells are the most potent antigen - presenting cells for eliciting primary immune responses.

«The most potent form of the hormone is indole -3-acetic acid, abbreviated IAA, and my lab members joke that IAA really stands for Involved in Almost Everything,» Strader said.

The anticholesterol drug cerivastatin, sold under the brand name Baycol, was the most potent medicine in its class in the late 1990s.

The design of MMP inhibitors (MMPIs) has largely focused on development of various compounds containing a zinc binding group (ZBG) in their structure, with the hydroxamate being the most potent one.

Phosphonate - based inhibitors are classified on peptide phosphonate; sulphonamide and sulfonyl phosphonate, the most potent; carbamoyl phosphonate, and bisphosphonate that have been identified more recently with an interesting activity on bone resorption.

«The hope is that the combination of the most potent chemotherapy, radiation therapy, and immunotherapy will help make patients who were previously considered non-surgical able to undergo curative surgery,» says Gan.

So the first line of this article states methane and carbon dioxide are the two most potent greenhouse gases, but of the four major contributors, they're the least influential.

«The next step is to perform preclinical studies with specific inhibitors of HDAC11 alone and in tandem with other existing immunotherapies, such as anti-PD1 / anti-PDL1 antibodies, in order to find the most potent combination.

It is also close to a region that last year saw the emergence of a form of malaria resistant to artemisinins, the most potent antimalarial treatment we have.

«We were always criticized about the potential side effects because 8 - PN is one of the most potent phytoestrogens known in nature, and that's not good news,» he said.

«High blood pressure is one of the most potent risk factors for developing cardiovascular disease.

There is broad agreement that first - rate scientists and engineers have helped make the U.S. military one of the most potent fighting forces in the world, notes the report from the U.S. National Academies» National Research Council and the National Academy of Engineering that was requested by the Department of Defense (DOD).

«This understanding is crucial if we are to combat these phenomena more effectively — without being blinded by anger or resentment, which is the hallmark of terrorism and its perpetrators — by using our most potent weapons: intelligence and knowledge,» Fuchs wrote.

Isolated from nutmeg, the chemical is the most potent activator of the cooling channel yet found in nature (ACS Med.

They turned to one of the most potent muscle relaxants known: the botulin toxin produced by the bacterium Clostridium botulinum.

Will he, in the wider European interest, be prepared to sacrifice some slice of that most potent of all symbols of nationhood — the land itself?

One of the most potent compounds, WWL113, turned out to work principally by inhibiting Ces3, a serine hydrolase enzyme that scientists have not studied in the context of obesity or diabetes.

Twelve days earlier a 12 - year - old Brooklyn boy, Omar Rivera, died after a wound he received on the basketball court became infected with methicillin - resistant Staphylococcus aureus (MRSA), a bacterium that has become resistant to one of the most potent drug classes in the current antibiotic arsenal.

As concentrations of the sex hormone estradiol — the most potent estrogen — declined during menopause, greater volumes of cardiovascular fat were found.

He said the relationship will streamline development of the most potent anti-filovirus products.

For some opioids, prescription rates increased dramatically; Dilaudid, one of the most potent yet addictive medications, went up 668.2 percent.

These chemical cocktails contain some of the most potent compounds known, and their fearsome power has awed people since the dawn of history.

Hydroxyl radicals are very damaging to cells, the most potent oxidizing agents known in biological systems.

Jealousy can also trigger harmful and violent behavior, so it is important to understand what are the most potent triggers of jealousy,» said Dr. Frederick.

Virus replication also was markedly reduced in mice when the most potent of the antibodies was injected before the animals were exposed to an H7 influenza virus.

But now, in a study appearing in the May 11 issue of Nature Nanotechnology, an MIT - led team reports achieving the most potent RNAi gene silencing to date in nonliver tissues.

In a related commentary, Robert Lindsay, M.B., Ch.B., Ph.D., of Helen Hayes Hospital, West Haverstraw, N.Y., writes: «In this issue of JAMA Internal Medicine, Greenspan and colleague present intriguing data on zoledronic acid, one of the most potent drugs in the bisphosphonate family — if not the most potent — approved for treatment of osteoporosis.»

«We now know that T cells parked where they reside in the skin are the ones eliciting the most potent anti-tumor response,» explains Paulos.

But their most potent weapon was artesunate.

To do this, they vaccinated mice with a combination of two of the T. cruzi proteins (called TcG2 and TcG4), which they had shown to be the most potent in provoking both an antibody and a T - cell immune response.

The ability to reconstitute community of some kind is one of the most potent protective factors for refugee mental health, Kirmayer says.

It is the most potent of the drugs in its class, and it works by interfering with the bone - breakdown process.

He recently has focused on a specific skin - barrier protein called filaggrin, which is broken down into a molecule called urocanic acid — the most potent absorber of UVB light in the skin, according to Elias.

If the finding that resident memory T cells are the most potent mediators of immunity holds up in different types of cancer, which I think it will, you could take a biopsy of the lung or the pancreas, for example, to see if there are resident T cells there.