Sentences with phrase «most significant decrease»

The same market also experienced the most significant decrease in listing inventory compared to the previous year: the 526 active listings represent a 27.6 per cent decrease from May of last year.

Not exact matches

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

But most important (and this would not necessarily work for everyone), since I have begun to use it, I have noticed a significant decrease in joint pain.

Mono - cropping exposes the soil surface allowing faster transpiration rate and reducing moisture, in the context of rubber plantations the rubber tappers suffered most since there is a significant reduction of moisture there is a dramatic decrease in sap supply of rubber trees.»

Although investigated in only 1 study (which found a significant decrease in patellofemoral pain from 35 % to 8 %), it continues to be a «fundamental principle that most therapists ascribe to as important in modern ACL reconstruction rehabilitation» and should be begin immediately during rehabilitation.

Usually not a permanent situation, most women experience a significant decrease when getting pregnant.

The most recent study report described in these same regions decreased tissue levels of 5 - HT and tryptophan hydroxylase, the synthesizing enzyme for serotonin, and no evidence of excessive serotonin degradation as assessed by levels of 5 - hydroxyindoleacetic acid (the main metabolite of serotonin) or ratios of 5 - hydroxyindoleacetic acid to serotonin.30 A recent article described a significant association between a decrease in medullary 5 - HT1A receptor immunoreactivity and specific SIDS risk factors, including tobacco smoking.40 These data confirm results from earlier studies in humans39, 41 and are also consistent with studies in piglets that revealed that postnatal exposure to nicotine decreases medullary 5 - HT1A receptor immunoreactivity.42 Animal studies have revealed that serotonergic neurons located in the medullary raphe and adjacent paragigantocellularis lateralis play important roles in many autonomic functions including the control of respiration, blood pressure, heart rate, thermoregulation, sleep and arousal, and upper airway patency.

«New fuel standards will decrease childhood asthma cases: Most significant improvement in global fuel standards for the shipping industry in 100 years, will also reduce number of premature deaths.»

«The most significant drug - metabolizing enzyme that decreased was cytochrome P450 2b10 (Cyp2b10),» said Professor Ohtsuki, who lead the research project.

It simply means that if you restrict food intake to an eight or nine - hour window from Monday to Friday, you can be more liberal with your old food choices, lose a significant amount of body fat, improve liver function, decrease cholesterol levels, prevent the development of type II diabetes and most important eat pizza, drink liquor and eat burritos during the weekend.

The most common effect noted in procedures lasting more than 3 hours was a significant decrease in pH, requiring IV bicarbonate.

Environmental factors, including pesticides, plastics, and other pollutants, have resulted in a significant decrease in the average testosterone levels for men, so most men will have, at least, a relative deficiency of testosterone (277).

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

This decrease was most significant in the third - generation rats.

• Extension of the school year or school day • Replacement of staff members relevant to the school's low performance • Significant decrease in management authority at the school level • Replacement of the principal • Restructuring the internal organization of the school • Appointment of an outside expert to advise the school • Replacement of all or most of the school staff (which may include the principal) • Reopening the school as a public charter school • Entering into a contract with a private entity to operate the school • Takeover the school by the State

This most recent decrease in math proficiency isn't a blip but a statistically significant trend.

«Illinois, like most every other state, has seen a significant decrease in the number of individuals who attend a college or university in order to obtain licensure to teach.

The most significant change is a vast decrease in the fund's expense ratio, from 1.90 % for «A» shares down to 1.15 %.

At the end of the blog, I started to discuss the social cost of taking the most common approach to resolving difficult debt issues: increasing income and decreasing expenses to allow a more significant pay - down of debt out of a person's monthly budget.

One of the most significant changes a senior dog will experience is his metabolism, which will decrease by about 20 %.

If the pet experiences significant discomfort, distress or decreased quality of life during this time, your veterinarian may recommend euthanasia as the most compassionate way to relieve pain and suffering.

If your dog has significant LIU (most commonly caused by a hypermature cataract or a rapidly - developing cataract), this also decreases the success rate.

Studies show that the most statistically significant way to decrease chronic arthritis pain in dogs is weight loss (3, 4, 5).

This study found that decreased Angles 2 and 5, increased diameter of the occipital lobe circle (F - diameter) and, to a lesser extent, decreased Angle 3 and increased AE, BC, BD and FG were the most significant variables.

For the Frequent Flyer, the most significant change is that the number of points required for Velocity transfers and ANZ Travel Rewards will be decreasing from 18 July, 2015.

If one plots the records from GISS, HADCru, RSS and UAH; GISS is the outlier, and three of the four primary global temperature measuring systems show a decrease over the most recent six years and a downward trend over the past decade; not that this establishes a significant trend yet.

«One of the most significant signals in the thermometer - observed temperature record since 1900 is the decrease in the diurnal temperature range over land, largely due to warming of the minimum temperatures... Climate models have in general not replicated the change in diurnal temperature range well.

The most significant volcanic gas is CO2, which has been monitored since 1958 through three eruption cycles Volcanic CO2 is greatest shortly after an eruption and then decreases exponentially over the subsequent years.

Already crop yields are decreasing, and with further increases in temperatures we expect significant impacts on the right to food, lives, and livelihoods, particularly of the poor and most vulnerable.

Most significant is the 24 % decrease of coal use in electric generation and the 12 % decrease in crude oil production.

Finds the annual mean temperature has decreased at a statistically significant rate, with the most rapid cooling during the Austral summer

Perhaps the most significant change is the diminishing sea ice cover, which is decreasing more rapidly than model predictions [Stroeve et al., 2007].

There was a significant decrease in recruitment rate for all of the plots combined (Fig. 2E; P < 0.0001, GNMM), and recruitment decreased most rapidly in younger forests (50 — 80 y old; P < 0.0001), followed by mature forests (80 — 120 y old; P = 0.0038), with no significant change detected in old - growth forests (≥ 120 y old; P = 0.507).

From 2010 to 2011, CO2 emissions from fossil fuel combustion decreased by 2.5 % due to: (1) a decrease in coal consumption, with increased natural gas consumption and a significant increase in hydropower used; (2) a decrease in transportation - related energy consumption due to higher fuel costs, improvements in fuel efficiency, and a reduction in miles travelled; and (3) relatively mild winter conditions resulting in an overall decrease in energy demand in most sectors.

Allianz Global Assistance reviewed more than 760,000 Americans» travel plans during the peak holiday travel season, Thanksgiving through New Year's, and found that while Paris saw a significant decrease in American travelers during last year's holiday season (down 12.8 percent from 2015), the city has risen for 2017 and remains as the second most popular European destination.

Most car insurance companies consider that the age of maturity and you can expect a significant decrease in your car insurance rates.

With the U.S. market accounting for a large portion of the overall trading volume in the cryptocurrency market, the volume indicators on most of the heavily traded cryptocurrencies are showing a significant decrease in trading activity.

It should be noted that the same software fix by Sony would most likely throttle the CPU and GPU clock speeds so they would not reach higher rates very often, which would indeed result in less overheating but also lead to a significant decrease in the smartphone's performance.

The most significant difference between the groups was on the aggressive subscale, with the control group scores increasing from baseline to postprogram and the PLL group decreasing during the same time period.

• Most (83.7 percent) believe that the level of mortgage delinquencies will decrease or stay the same, a significant improvement over last quarter.

This is significant because that profit marks a decrease from the second quarter of 2009 when profits averaged $ 1,358 per loan, according to the MBA's most recent Quarterly Mortgage Bankers Performance Report, which measures the performance of independent mortgage bankers and subsidiaries of banks, thrifts and hedge funds.