Sentences with phrase «most single genes»

Last autumn Jean Weissenbach and Marc Lathrop came up with a new type of genetic map which makes it possible to map most single genes in «months instead of years», according to Nigel Spurr, a cancer researcher and gene mapper at the Imperial Cancer Research Fund.

Not exact matches

Alpha -1-antitrypsin deficiency (A1ATD) is the most common genetic disease of the liver, and is caused by a single nucleotide change in the gene that codes for alpha -1-antitrypsin (A1AT), an enzyme inhibitor that normally protects bodily tissues.

«Most PRAs, including the one in Phalenes and Papillons, are recessive and caused by single gene defects and small sample numbers can lead to breakthroughs.

The hypocretin receptor 2 gene could be the single most important gene in human narcolepsy, says Michael Aldrich, a neurologist and director of the University of Michigan's Sleep Disorders Center.

In the intervening years, we have come to realize that many of the most interesting and important phenomena in human biology are not caused by any single gene.

«When most people think about cancer genetics, they think about single key mutations that foster tumor formation — very specific things like the BRCA genes,» said Joe R. Delaney, PhD, a fellow in the Clinical Translation program at UC San Diego Moores Cancer Center and lead author of the paper published February 15 in Nature Communications.

A mutation in the LRRK2 gene is the single most common inherited cause of Parkinson's disease.

The tool acts with surgical precision to replace only abundances that have most likely dropped out and can be used in any type of single - cell gene - expression analysis.

That pattern of inheritance would suggest the strong effect of a single gene mutation, and it would most likely crop up in families that had a lot of shared genes through the intermarriage of first cousins.

Sickle cell disease is the world's most common serious condition due to a single gene mutation.

Hereditary predisposition to cancer is sometimes due to a single high - risk genetic change, like a mutation in the BRCA1 or BRCA2 genes for breast cancer, but most of the time, the disease is the result of multiple gene variants that add up, environmental risk factors, and a big element of chance.

That's unusual; most microbial genomes consist of a single chromosome, sometimes with some extra genes carried on bits of extraneous DNA called plasmids.

It is particularly useful when clinicians want to identify an illness or gene mutation involving a single patient or the patient and two or three other family members, which is the most common clinical situation for undiagnosed diseases.

«Mutations in Shell explain the single most important economic trait of the oil palm: how the thickness of its shell correlates to fruit size and oil yield,» explains Dr. Rajinder Singh of the MPOB, first author of the Nature paper describing the Shell gene.

As a result, most possess only a single disease - resistance gene.

Most of the afflicted family members, but none of those who sleep normally, carry a single base - pair mutation in a gene called hPer2, the researchers report 12 January in a paper published online in Science.

Dr Ton added: «Plant immunity that is controlled by a single resistance gene, on which most conventional breeding programs are based, is comparably easy to overcome by a pathogen.

Most importantly, by looking at a single cell level, researchers were able to correlate the chromosomal make - up of an embryo to a subset of 12 genes that are activated prior to the first cell division.

This, in my opinion, is one of the most compelling parts of this study: in vivo functional validation of a single base change in a noncoding enhancer that's hundreds of thousands of bases away from the gene it regulates.

Topics for the scientific sessions are: Single cell genomics and gene expression Genetic interactions RNAi and somatic cell genetics Protein - DNA interactions Cancer The meeting also highlights existing opportunities for academic and industrial researchers to access automated cell - based and biochemical technologies based at the Karolinska High Throughput Center; home to one of the most sophisticated, state - of - the - art, ultra-high performance liquid handling and analysis platforms in Europe.

«It's probably the single most common gene fusion in human cancer,» said study co-leader Antonio Iavarone, MD, professor of neurology and of pathology and cell biology (in the Institute for Cancer Genetics) at CUMC.

The most radical news at the conference was the first reported use of CRISPR / Cas9 to generate precise genome edits (changing only a single base pair) in two genes, not only in cell lines in vitro, but also in specific tissues of embryos in ovo.

A single nucleotide polymorphism (SNP) in the ARID5B gene has been identified as a risk factor in the most common form of childhood leukaemia

Most biological experiments, however, still take a reductionist approach to this vast array of data: knocking out a single gene and seeing what happens.

Fragile X is the most common known single - gene cause of autism and the most common inherited cause of intellectual disability.

The most famous one is the gene that causes sickle cell anemia: While two copies of that gene cause a disease that's devastating in its own right, a single copy creates a healthy child with strong malarial resistance.

With PrediXcan, validation studies only need to test a few thousand genes at most, instead of millions of potential single mutations.

Our supermatrix expands upon these previous studies by bringing together sequences from a wide array of molecular studies, supplemented by new data for four genes, to yield a single primate phylogeny with strong support for the monophyly of most primate genera, families, and higher - level taxa (Primates, Strepsirrhini, Lemuriformes, Lorisiformes, Haplorhini, Tarsiiformes, Simiiformes, Catarrhini, Platyrrhini).

«Unfortunately, the gene - centric approach to cancer treatment which, for the most part, has relied on using a single drug to attack an individual mutation, has proved effective for only a relatively small percent of patients,» says Califano.

In humans, PKD is one of the most common diseases caused by a mutation in a single gene.

Some of the team's most significant findings since 2009 were the identification of a gene mutation associated with blood cancers and the discovery of chromosomal crisis where the genome can be shattered into hundreds of fragments in a single cellular catastrophe.

The most common genetic killer of infants, a disease known as spinal muscular atrophy, is caused by mutations in a single gene.

In contrast to Mendelian disorders (e.g., Huntington's disease, sickle cell anemia) in which variation in a single gene causes disease, common complex disorders, such as heart disease, diabetes, and most cancers, develop as a result of both genetic and environmental factors.

Genetic Mistake Causes Most Thyroid Cancer Kimmel Cancer Center researchers have found that a single genetic mistake in the BRAF gene causes about two - thirds of papillary thyroid cancers.

In most cases the putative coding sequences of OR and V1R genes span a single exon and the additional exons contains only UTRs.

Amphimedon has single copies of most metazoan kinase classes, but has several expansions of over 50 genes per class.

However, most differentiated regions contained very few annotated genes: 59 segments (57.8 %) contained three or fewer genes and 30 (29.4 %) localized to a single gene.

The length of the loop is at least 8 nucleotides long; there is no apparent maximum in loop length, even in organisms possessing only a single Dicer gene, contra (6), even though most taxa like vertebrates with single Dicer genes never show loop lengths greater than ~ 40 nucleotides.

The clearest finding from proteomics experiments is that most human genes have a single main protein isoform, while those alternative isoforms that are identified tend to be the most biologically plausible: those with the most cross-species conservation and those that do not compromise functional domains.

The single most highly represented family of dysregulated genes was the key liver P450 cytochrome detox gene which is needed in the first of three steps for detox (30 genes in total).

It seems most molecular genetic approaches in relating heritability of personality characteristics such as criminality to a single gene frequently suffer from failures in replication.