The flurry of action — at breakneck speed compared with
most vaccine development — shows how a health emergency and a guaranteed global market can prod this process to move a lot faster than usual, with streamlined approvals and millions of dollars in government support.
Not exact matches
Next year, UTMB will start building a high - containment lab that can handle even the
most dangerous viruses — one of only a handful in the U.S. With that capacity, and the expertise concentrated at UTMB, the new center should «make some very important contributions» to
vaccine development, La Montagne predicts.
But scientific and economic obstacles have stymied the
development of effective
vaccines against many of the developing world's
most deadly diseases, such as malaria and HIV as well as pneumococcus, the leading
vaccine - preventable killer of children under the age of five.
The cells have contributed to more than 60,000 research papers, the
development of a polio
vaccine in the 1950s and,
most recently, an international effort to characterize the genome, known as ENCODE.
With
most of these firms or their
vaccine subsidiaries based in Europe, this makes the continent home to 90 per cent of global
vaccine production and nearly half of its R&D (Drug
Development and Delivery, vol 11, p 26).
That process faces the same
development delays as in 2009, when
vaccine arrived too late for
most people.
Ahead of this year's World Immunization Week — celebrated in the last week of April — we're reviewing some of the
most important
vaccine breakthroughs in recent history, as well as a looking to the future of
vaccine development for diseases like HIV / AIDS, Zika, and Herpes.
Dr. Polonis has spent
most of her 28 years of research experience associated with the Military HIV Research Program and focusing on HIV
vaccine development.
As the single
most important cause of serious lower respiratory tract disease in infants and young children in the United States and globally, RSV is of considerable public health importance and a high priority for
vaccine development.
Smallpox has been all but eradicated in the West thanks to the
development of a
vaccine (which
most of our parents had).
We could be much closer to the
development of a
vaccine against RSV, the
most important viral cause of pneumonia and wheezing illness in infants and young children all over the world.
Since that post, there have been exciting
developments in the progress of the two
most advanced of these immunotherapies: PD01A, the AS - targeting active
vaccine from Austrian biotechnology startup AFFiRiS AG, developed using its patented «AFFITOME» neo-antigen discovery platform of molecular mimicry; and PRX002, a humanized monoclonal Ab (mAb) under
development from Prothena Corp PLC, the successor of aggregate - clearing immunotherapy pioneer Élan Pharmaceuticals.
Scientists and
vaccine developers involved in EVI projects presented project progress and research findings, highlighting one of the
most important areas of EVI's activities; translation of research on diseases of poverty
vaccines, focusing on early stages from preclinical to clinical
development through harmonisation.
Trained as a physician, specialised in epidemiology, clinical pharmacology and vaccinology, Dr Odile Leroy has spent
most of her carrier in
vaccine development, as a scientist in Africa for nine years, as corporate clinical director of airborne
vaccines for 10 years at Sanofi Pasteur.
In September 2017, the two received the Lasker - DeBakey Clinical Medical Research Award, the country's
most prestigious honor for biomedical research, for their significant research leading to the
development of HPV
vaccines.
Most recently, CRI has launched a new «venture philanthropy» program called the Cancer
Vaccine Acceleration Fund (CVAF) as a means to catalyze
development of next - generation therapeutic cancer
vaccines and other immunotherapies by helping to address the critical shortage of capital available for early stage clinical trials.
A good knowledge of correlates of protection could predict the efficacy of novel
vaccines at early stages of
development and help identify the
most promising candidates for
vaccine trials.
The
most famous, oldest, and
most commonly used immortal cell line, dubbed HeLa, originated in a tumor sample taken from an African - American woman, Henrietta Lacks, who is the subject of the recent book The Immortal Life of Henrietta Lacks.9 The tumor cells, harvested at Johns Hopkins Hospital, gave rise to the eponymous HeLa cell line which researchers have used continuously since her death in 1951 for numerous experiments, including Jonas Salk's
development of the polio
vaccine.
Once I came to the conclusion that there was no valid reason for
most yearly pet
vaccines — and there was a possibility that
vaccines could trigger the
development of serious diseases — I felt I could no longer work at a conventional veterinary clinic.
Still Important Today Despite the
development of excellent and safe
vaccines against rabies, every 10 minutes, somewhere in the world, a person dies of rabies,
most of them children.