For every 50 percent decrease in bedroom floor
mouse allergen levels, there were decreases in how often children had asthma symptoms, used medications, and had an acute or Emergency Department visit for asthma.
The researchers also measured
mouse allergen levels in the children's homes (bedroom floor, bed and airborne) and assessed their lung function.
One group of 166 participants received professional IPM and family education about how to reduce
mouse allergen levels at home; the other group of 168 participants received family education only.
The average bedroom floor
mouse allergen levels across all follow - up visits were 2 and 2.5 micrograms per gram in IPM plus education and education only groups, respectively, with no statistical difference.
Because one small study suggested that a professional integrated pest management (IPM) intervention could result in large reductions in home
mouse allergen levels, the researchers wanted to know whether professional IPM reduced asthma morbidity in asthmatic children who are known to be allergic to mice and also regularly exposed to mouse allergens at home.
Both groups, however, saw substantial reductions in
mouse allergen levels and substantial improvements in asthma.
Not exact matches
Allergen levels significantly increased, however, after the
mice were given antibodies that neutralized IL - 22, indicating that Clostridia - induced IL - 22 prevents
allergens from entering the bloodstream.
When exposed to peanut
allergens,
mice in both conditions showed reduced
allergen levels in their blood, compared to controls.