Sentences with phrase «mouse and human brain»

Researchers demonstrated that the drugs pemetrexed and gemcitabine killed cells from mouse and human brain tumors, called group 3 medulloblastoma, growing in the laboratory.

In a new study, published 11 August in Science, researchers classified neurons from mouse and human brain tissue by their methylation patterns.

Because the mouse and human brains have much in common, co-lead study investigator William Muñoz, an MD - PhD student at NYU Langone, says the team's findings advance the field's understanding of how the brain processes touch, smell, hearing, sight, and taste.

Because the mouse and human brains have much in common, co-lead study investigator William Muñoz, an MD / PhD student at NYU Langone, says the team's findings advance the field's understanding of how the brain processes touch, smell, hearing, sight, and taste.

«Our goal is to create a parts list of both mouse and human brains.»

Not exact matches

Researchers have injected mice with human breast, ovary, colon, bladder, brain, liver and prostate tumors, and their new drug has killed the tumors every time.

This need stems from the mammalian brain, a commonality that affects cats, dogs, mice... and humans!

This region has the highest oxytocin levels in the brain and has high levels of oxytocin receptors across all species from mice to humans.

Compared with mice with cells from healthy people as well as non-chimera mice, those whose brains had human schizophrenia cells were more afraid to explore a maze, more anxious, more antisocial, less able to feel pleasure (from sipping sugar water), worse at remembering, and more sleepless — all of which characterize people with schizophrenia, too.

«We don't know if the observed reversibility of the disease symptoms as observed in the mouse,» he says, «exists in humans who have a much longer period of pre - and post-natal brain development than mice — months and years in humans, weeks in mice.»

Implanting human brain organoids in a mouse brain gives them everything they need to grow and develop.

The Salk team therefore took human brain organoids that had been growing in lab dishes for 31 to 50 days and implanted them into mouse brains (more than 200 so far) from which they had removed a tiny bit of tissue to make room.

The mice behaved just like others of their kind, as far as scientists could tell, and they also looked the same — except for the human mini brain that had been implanted into each rodent's own cortex, made visible by a little clear cover replacing part of their skull.

In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

Duke scientists have shown that it's possible to pick out key changes in the genetic code between chimpanzees and humans and then visualize their respective contributions to early brain development by using mouse embryos.

The researchers, reporting online March 5 in the American Journal of Reproductive Immunology, also say they found that an anti-inflammatory drug that is FDA - approved for rheumatoid arthritis and is believed to be safe for humans to take during pregnancy halted the brain injury in mouse offspring.

To investigate, Walker Jackson of the Whitehead Institute in Boston, Massachusetts, and his colleagues created mice with a mutation associated with the human prion disease Fatal Familial Insomnia and injected some of their brain tissue into the brains of mice without the mutation.

Beta - amyloid protein is found in the brains of mice and humans.

An inflammatory protein that triggers a pregnant mouse's immune response to an infection or other disease appears to cause brain injury in her fetus, but not the premature birth that was long believed to be linked with such neurologic damage in both rodents and humans, new Johns Hopkins - led research suggests.

In the brain, his FFI mice develop neuronal loss in the thalamus and his CJD mice experience spongiosis in the hippocampus and the cerebellum, reflecting the damage seen in the brains of human patients.

So he implanted various human tumors — including ovarian, breast, colon, liver, and brain — into mice and then injected the animals with antibodies that disable CD47.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

The summary of his experiment that Gage sent to the neuroscience meeting did not specify the size of the human brain organoids he and his colleagues implanted into mice; he told STAT that he could not talk about the work because he had submitted it to a journal.

The loss of a single gene in mice can affect social behavior and impair their brains» ability to filter out distractions — both characteristics of several neurological diseases in humans.

That would be getting close to the number of cells in a mouse brain,» raising the distant prospect of a human brain organoid with cognitive and even emotional capacities, all while sitting in a lab dish.

At a neuroscience meeting, two teams of researchers will report implanting human brain organoids into the brains of lab rats and mice, raising the prospect that the organized, functional human tissue could develop further within a rodent.

Further research showed that fetal mice bred to lack these molecules — like animals lacking MHCI, and like humans with autism or schizophrenia — undergo inadequate synaptic pruning in some parts of their brains.

Scientists have assumed these tunes are hardwired in their tiny mouse brains and doubted that rodents modify their songs after hearing others — a cognitive feat similar to vocalizations by birds and some mammals, including dolphins, bats and humans.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

In 2008, when he fed Lactobacillus to mice with a transplanted human microbiome, he observed metabolic changes in the animals» gut, liver, kidneys, and parts of the brain.

Meanwhile, a protein commonly found in the blood of young mice (and humans) may hold the key to rejuvenating brain cells.

The normal mice's brain plaques seemed to be built from human A-beta protein, and the only source of that was the blood of the mutated partner mouse.

The LPA receptor is expressed in the brain of human fetuses, just as in mice, and in the same types of neural progenitor cells.

Using the supercomputers at Almaden and Lawrence Livermore National Laboratory, the group simulated networks that crudely approximated the brains of mice, rats, cats and humans.

In a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cells.

«In brain tissues of mice and humans, there are two microRNAs called miR - 7 and miR - 671 that bind to it.»

The mice benefited from human stem cells called glial progenitors, immature cells poised to become astrocytes and other glia cells, the supposed support cells of the brain.

By assessing the survival of the cells that engulf the particles and measuring the levels of red or green light that they emitted, the researchers determined which formulation of particles performed best, then tested that formulation in mice with human brain cancer derived from their patients.

But recent studies in both humans and lab mice have suggested that motor neurons in the brain — the upper motor neurons — may be involved in disease progression, although the extent and significance of this involvement has remained unknown.

They injected the particles directly into mice with an experimental human brain cancer, and into the brains of healthy mice for use as comparison.

Since the current work was done in mice, O'Leary and Zembrzycki want to confirm the link in humans by using brain scans to measure the natural variation in the neocortical areas and search for potential links to disease.

By pairing a receptor that targets neurons with a molecule that degrades the main component of Alzheimer's plaques, the biologists were able to substantially dissolve these plaques in mice brains and human brain tissue, offering a potential mechanism for treating the debilitating disease, as well as other conditions that involve either the brain or the eyes.

Studying mouse communication and behavior can produce great insight into brain mechanics and systems and possibly give researchers valuable insight into how human brains work.

Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothing of the kind.

2 - D cell - culture and mouse experiments also provided key evidence of the virus's modus operandi; although the rodent brain doesn't harbor the full contingent of human neural stem cells, it has blood vessels and immune - system components that organoids lack.

The result, says Flajolet, is a brain that is hard and transparent, almost «like glass,» which allowed the researchers to see the amyloid plaques in full detail and in 3D, in a full mouse brain hemisphere, as well as in small blocks of human brain tissue.

Buxbaum and his coworkers point out that FOXP2 is also expressed in the brains of songbirds such as finches and canaries, and further studies of the gene in mice might provide a better understanding of its role in human communication.

«Those findings also suggest that FGF21 is regulated the same way in humans as in mice and that the process involves the expression and activation of certain proteins in the brain.»