This factor is the first lung molecular marker during
mouse and human development and is essential for lungs to mature properly in an embryo.
Not exact matches
«We don't know if the observed reversibility of the disease symptoms as observed in the
mouse,» he says, «exists in
humans who have a much longer period of pre -
and post-natal brain
development than
mice — months
and years in
humans, weeks in
mice.»
PDX models are created by implanting cancerous tissue from a
human primary tumor directly into immunodeficient
mouse or rat models, enabling acceleration of oncology research or drug discovery
and development programs.
Yet, in
mouse embryos the researchers found that the
human enhancer was active earlier in
development and more active in general than the chimpanzee enhancer.
Duke scientists have shown that it's possible to pick out key changes in the genetic code between chimpanzees
and humans and then visualize their respective contributions to early brain
development by using
mouse embryos.
Prof. Marine
and his team generated a refined
mouse model that faithfully reproduces the early stages of melanoma
development in
humans.
Many universities
and pharmaceutical companies are engaged in research
and development using genetically modified
mice that have certain genes manipulated to reproduce
human diseases.
Furthermore, the findings illustrate the fundamental importance of HYAL2
and hyaluronan turnover for normal
human and mouse development.
«Epigenetic changes promote
development of fatty liver in
mouse and human.»
Using a
mouse model of HSV - 1 as well as autopsied samples of
human adult
and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female
mice could travel to the nervous systems of their yet unborn babies, preventing the
development and spread of infection during birth.
A screen for
mouse genes dependent on dHAND, a transcription factor implicated in neural crest
development, identified Ufd1, which maps to
human 22q11
and encodes a protein involved in degradation of ubiquitinated proteins.
The group has already started tweaking
human iPS cells using the same genes that Saitou pinpointed as being important in
mouse germ - cell
development, but both Saitou
and Hayashi know that
human signalling networks are different from those in
mice.
In
humans and mice, the gene is associated with height, face
development and other traits.
Early in embryonic
development, both
mouse and human placentas rely on the same set of ancient cell - growth genes.
But Husseini Manji, head of neuroscience research
and development at Janssen Pharmaceutical Companies in Titusville, New Jersey, cautions against assuming that results in
mice will bear out in
humans.
Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman,
and Gail Martin, have allowed scientists to generate genetically customized strains of
mice that have revolutionized studies of organismic
development and immunity
and have provided countless models of
human disease.
«We identified that the peculiar look of these naked lizards is due to the disruption of the ectodysplasin - A (EDA), a gene whose mutations in
humans and mice are known to generate substantial abnormalities in the
development of teeth, glands, nails
and hairs», says Michel Milinkovitch.
Hebrok found that when the Brg1 gene is knocked out in
mice that are predisposed to PanIN
development and subsequent PDA, lesions form that are similar to
human IPMN.
The researchers found that PAI - 039 inhibited the migration of cultured
human coronary artery smooth muscle cells,
and prevented the
development of blockages in arteries
and bypass grafts in
mice.
In his current position at The Jackson Laboratory, he has overall responsibility for the ongoing operational
development of the PDX resource, which generates, banks,
and distributes patient - derived xenograft (PDX)
mouse models of
human cancers.
«This association is important for lung
development in
mouse embryos,
and at least for one of these long non-coding RNAs, important for
human lung function.»
Green fluorescent protein labeling allowed them to see the early
development pattern
and show that lncND, which ordinarily is not present in
mice — lncND is present only in some primates including
humans — had a functional effect on
development.
«With this
development, we are now able to culture both
mouse and human organoids, providing a very powerful tool in our fight against pancreatic cancer,» explains Tuveson.
The researchers used tools of epigenomic analysis to trace the specific epigenetic switches controlling each of thousands of genes in both
mouse and human retinal cells as the cells progressed through
development.
Our side by side analysis uncovers the dynamics of epigenetic programming occurring in germ cell
development at single base resolution in
human and mouse cells.»
The
mice were then placed on a calorie - restricted diet, which usually precedes the
development of anorexia in adolescent
humans and may act as a trigger for eating disorders.
Though these findings have been obtained in
mice, the scientists hypothesize that disrupted coordination between the
development of the microglia
and that of the brain contributes to an increased risk of such neurodevelopmental disorders as autism
and schizophrenia in
human beings.
Further testing found these
mice had lower - than - expected growth hormone
and insulin - like growth factor (IGF1) levels in the blood, potentially explaining the small stature
and delayed
development seen in
human patients.
UCLA scientists, in collaboration with teams in China, have used the powerful technology of single - cell RNA sequencing to track the genetic
development of a
human and a
mouse embryo at an unprecedented level of accuracy.
The new study is based on the
development of
mouse models manifesting the disease that causes megalencephaly, spasticity
and ataxia in
humans.
His team have begun recolonising the primate scaffolds with
human cells that line blood vessels, the first step towards
human - scale biolimb
development,
and have started experiments using
human myoblasts in rats instead of the
mice ones.
«Deviant alternative splicing, or mutations in the products of alternative splicing, have been tied to cancer, autism
and serious
development disorders, both in
mice and in
humans.
«
Mouse and human kidney
development compared: Findings may lead to advances in the study
and treatment of kidney disease.»
To find out why, they examined genes in both
mice and humans that turned on during peak brain
development and spotted a DNA snippet, ARHGAP11B, that was active only in
humans.
A second study, by a different research group, tracked
human and mouse embryo
development from fertilized egg to about six days later, just before the embryo implants in the uterine wall.
What we do know is that in
mice (
and so, presumably, in
humans) FOXP2 is active in the brain during embryonic
development.
The team found lower levels of TRNP1 in areas that were destined to form folds,
and higher levels in areas that would not have developed them, suggesting that the protein produced by the gene inhibits more complex brain
development in
humans as well as in
mice.
In 2012, scientists got their first hint that a gene called TRNP1 might influence brain
development in both
mice and humans.
«Assuming that we can equate developmental stages in
mice and humans,» Snyder reflects, «these findings might be relevant to brain
development and the genesis of anxiety in people too.»
The role of POU6F2 in corneal
development and thickness in
mice, however, points to the gene as a possible risk factor for glaucoma in
humans that deserves further investigation.
The discovery may help explain why
humans evolved more elaborate brains than
mice,
and it could suggest ways to treat disorders such as autism
and epilepsy that arise from abnormal neural
development.
Preclinical studies in
mice and human cells suggested that the removal of SnCs significantly reduced the
development of post-traumatic OA
and related pain
and created a prochondrogenic environment for new cartilage to grow
and repair joints.
In a recent review, researchers from the French Institute of Health
and Medical Research (INSERM), Atomic Energy Commission (CEA)
and University of Paris - Diderot compared the effects of six potential EDs on the function of rat,
mouse and human fetal testis at comparable stages of their
development.
Investigating
mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse models for biological for research The congress aims to promote the International
Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
Mouse Phenotyping Consortium (IMPC)
mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse lines, importance of
mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse phenotyping & clinical
and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota
and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for
human diseases»
and recent
developments in
mouse models phenotyping ima
mouse models phenotyping imaging.
Using
mouse models that replicate the complexity of
human hepatocellular carcinoma genetics, he is working on unravelling the mechanisms of regeneration
and cancer
development in the liver.
It's such a subtle defect that these animals, called Aspm knockout
mice, provide limited insight into
human cortical
development, says Walsh, who leads the Allen Discovery Center at Boston Children's Hospital
and Harvard Medical School.
While this is an attractive idea, an analysis of regulatory element evolution shows that lineage - specific regulatory innovation for
development occurred prior to
human and mouse divergence [78].
The 19 NIH institutes, centers
and offices contributing to the Knockout
Mouse Project are: the NIH Office of Strategic Coordination / Common Fund; NCRR; the National Eye Institute; NHGRI; the National Institute of Allergy
and Infectious Diseases; the National Heart, Lung
and Blood Institute; the National Institute on Aging; the National Institute of Alcohol Abuse
and Alcoholism; the National Institute of Arthritis
and Musculoskeletal
and Skin Diseases; the Eunice Kennedy Shriver National Institute of Child Health
and Human Development; NIDCD; the National Institute of Dental
and Craniofacial Research; the National Institute of Environmental Health Sciences; the National Institute of General Medical Sciences; the National Institute of Mental Health; the National Institute of Neurological Disorders
and Stroke; the National Institute of Diabetes
and Digestive
and Kidney Diseases; the National Cancer Institute;
and the Office of AIDS Research.
Genetically engineered
mice now act as robust engines for the generation of diverse repertoires of affinity - matured, fully -
human variable regions with intrinsic drug - like properties necessary for successful
development including high potency, specificity, manufacturability, solubility
and low risk of immunogenicity.
«Our decision to procure these knockout
mouse lines
and data
and make them available to the research community will yield tremendous benefits, both in the short
and long terms,» said NIH Director Elias A. Zerhouni, M.D. «This trans - NIH initiative will place important
mouse models into the hands of researchers, speeding advances in the understanding of
human disease
and the
development of new therapies.