Sentences with phrase «mouse and human forms»

There is also significant sequence overlap with the mouse and human forms.

Not exact matches

These four genes and their proteins constitute the heart of the biological clock in flies, and with some modifications they appear to form a mechanism governing circadian rhythms throughout the animal kingdom, from fish to frogs, mice to humans.

University of California, Irvine neurobiologists Leslie Thompson and Joseph Ochaba with the Departments of Neurobiology & Behavior and Psychiatry & Human Behavior and their colleagues from UCI and from Children's Hospital of Philadelphia have shown that reducing the aberrant accumulation of a particular form of the mutant Huntingtin protein corresponds to improvement in symptoms and neuroinflammation in HD mice.

The human (and all the other) genome projects were predicated on the reasonable assumption that spelling out the full sequence of genes would reveal the source of that diversity of form and attributes that so readily distinguish worm from fly, mouse, chimp and human.

«If the effects of alcohol on memories to fearful responses are similar in humans to what we observe in mice, then it seems that our work helps us better understand how traumatic memories form and how to target better therapies for people in therapy for PTSD.

Enormous projects such as ENCODE (for humans and mice) or modENCODE (for other lab model systems, such as the fly Drosophila or the worm C. elegans) have been devoted to collecting these data in order to analyse and interpret them in the framework of genomic data and to form hypotheses about functions and relations.

These cells form in the uterine lining early in pregnancy, and in mice and humans they persist through delivery.

The team led by Dr Rubén López — of the UAB's Department of Cell Biology, Physiology and Immunology and Institute of Neuroscience, and the Centre for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED)-- used a genetically modified mouse that produces the human form of IL - 37 to study the function of this protein.

Hebrok found that when the Brg1 gene is knocked out in mice that are predisposed to PanIN development and subsequent PDA, lesions form that are similar to human IPMN.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

Investigators found that autophagy plays a role in clearing IAPP from pancreatic beta cells using three experimental models: pancreatic beta cells, isolated pancreatic islets from mice that express the human form of IAPP, and human islets.

Mitchell, a biomedical informaticist, and first author Colin Huber statistically analyzed data gleaned from 51 existing lab studies in mice genetically augmented with a human form of Alzheimer's.

Prins took human prostate stem cells from deceased young adult male organ donors and implanted the cells into mice, where they formed human prostate tissue.

Sun and her colleagues studied transgenic mice that were engineered to carry human genes known to contribute to certain forms of ALS.

Miller, then - graduate student Sarah DeVos, PhD, and colleagues studied genetically modified mice that produce a mutant form of human tau that easily clumps together.

Grima used two mouse models of Huntington's disease: one with a human version of the mutant Huntingtin protein and another with an aggressive form of the disease that contains only the first portion of the mouse Huntingtin protein.

The study, which is published in the journal Nature Communications, was conducted on human tumour cells and on mice, and offers hope of a much improved therapy for a severe form of cancer.

In today's Cell, researchers report that the DNA on the end of human and mouse chromosomes forms a loop, with the exposed end tucked back into the DNA strand.

The researchers then prepared a mouse - pellet form of an unhealthy human diet, high in fat and low in fiber, and housed svelte and heavy mice together again.

The team found lower levels of TRNP1 in areas that were destined to form folds, and higher levels in areas that would not have developed them, suggesting that the protein produced by the gene inhibits more complex brain development in humans as well as in mice.

Researchers studying a protein that causes a hereditary degenerative brain disease in humans have discovered that the human, mouse and hamster forms of the protein, which have nearly identical amino acid sequences, exhibit distinct three - dimensional structures at the atomic level.

North says his group has already generated a human chimeric form of MAG - 1 that is equally effective as mouse MAG - 1, and they are now generating a humanized form for use in patients.

The hippocampus plays a well - known role in the brain's ability to form new memories and to help animals — from mice to humans — navigate through complex environments.

To overcome this, researchers from the University of Texas Southwestern Medical Center and Johns Hopkins University stabilized pri - miRNAs by expressing a dominant negative form of DROSHA, the RNase III enzyme responsible for pri - miRNA cleavage, in a variety of human and mouse cell lines.

When the mouse (and also human) embryo enters the uterus, water gets pumped between the cells to form a protective and nutrition -...

The researchers found that bacteria forming part of a cluster were more likely to be taken up by human cells and to survive in them than the microbes without close relatives; the cluster strains also caused more severe disease in mice.

They also found that drugs that target this newly identified cancer pathway can prevent tumor growth, both in human cancer cells and mice with a form of brain cancer.

By carefully guiding the cells» choices at each fork in the road, Loh and Chen were able to generate bone cell precursors that formed human bone when transplanted into laboratory mice and beating heart muscle cells, as well as 10 other mesodermal - derived cell lineages.

An international team of scientists, including four from Brown University, conducted and analyzed tests using a «knock - in» mouse carrying a gene for a mutant DNA / RNA binding protein called TDP - 43, which causes a form of inherited ALS in humans.

Upon orthotopic transplantation into immunodeficient mice, these organoids form normal pancreatic ducts and acinar tissue resembling fetal human pancreas without evidence of tumour formation or transformation.

By looking at and comparing the genomes of humans, mice, cows, and two types of fish, these researchers were able to discern general patterns in what led to the emergence of new life forms in different time periods.

We therefore suggest that the presence of the mutated transgenes (AβPP and PS1), which are per se the basis for the genetic form of Alzheimer's disease in humans, directly interferes with gut function as shown here for the disease model mice.

CAST / EiJ mTR — / — mice exhibit significant deficits in tissue renewal during adulthood, even in the first generation, and progressive worsening of the phenotype with successive generations, similar to what is seen in other background strains with these mutations and in the genetic anticipation observed in successive generations of families with autosomal dominant forms of the human genetic disorder of telomerase components, dyskeratosis congenita.

Last year, Mandriota and collaborators demonstrated that in a cancer mouse model, concentrations of aluminum in the amount of those measured in the human breast are able to transform cultured mammary epithelial cells, allowing them to form tumors and to metastasize.

I am also studying a mouse model that exhibits sex reversal, craniofacial defects and shortening of the limbs characteristic of some forms of human dwarfism.

We first evaluate the Neu5Gc content of various foods to show that red meats are particularly rich in orally bioavailable Neu5Gc and then investigate human - like Neu5Gc - deficient mice fed this form of Neu5Gc.

The Nut Job 2's episodic plot is little more than a clothesline on which to hang manic action sequences, which, despite a few sparks of inventiveness — a battle atop a hot - air balloon, a group of kung fu - fighting mice forming a human - sized warrior by inhabiting an empty hazmat suit — are ultimately a repetitive succession of swooping, running, diving, and driving.

Genetic studies in humans and mice with idiopathic epilepsy have revealed a number of causative genes for specific forms of epilepsy 31.

The six different forms of our shape - shifting hero — human, lizard, mouse, piranha, lion and hawk — each have different abilities and make up just a small percentage of the colorful cast of characters included in this non-stop action / adventure platformer.

The six different forms of our shape - shifting hero, human, lizard, mouse, piranha, lion and hawk, make up just a small percentage of the cast of this non-stop action / adventure platformer!

Building an artistic language, which includes altered forms of familiar animated characters, such as Mickey Mouse, the Michelin Man, and SpongeBob SquarePants, his cartoonlike hybrids are often depicted in various states of the human condition.