Sentences with phrase «mouse and human germs»

The clinical applications are much more remote, because mouse and human germs cells develop differently and may require different conditions.

Not exact matches

The group has already started tweaking human iPS cells using the same genes that Saitou pinpointed as being important in mouse germ - cell development, but both Saitou and Hayashi know that human signalling networks are different from those in mice.

Before birth, mouse and human ovaries contain an abundant supply of germ cells, some of which will develop into the eggs that will ultimately be released from follicles during ovulation.

Work in germ - free mice shows providing the right human microbial communities can restore growth, likely by restoring the proper connections between growth hormone and insulinlike growth factor 1.

Our side by side analysis uncovers the dynamics of epigenetic programming occurring in germ cell development at single base resolution in human and mouse cells.»

The germ cells made from stem cells stopped differentiating in the mice before they produced mature sperm (likely because of the significant differences between the reproductive processes of humans and mice) regardless of the fertility status of the men from whom they were derived.

Establishment of a human embryonic germ cell line and comparison with mouse and human embryonic stem cells.

PRDM14 is required for the development of mouse germ cells [17], and also known as a pluripotent marker for mouse and human ES cells [17], [52].

Among the early germ cell markers examined, VASA is a candidate gene for detecting pre-meiotic germ cell differentiation from monkey ES cells, because its expression is detected earlier in the primordial stage of germ cell development in comparison to that of PIWI family genes in vivo in mice and humans [11], [36]--[38], [49].

Previous studies demonstrated the VASA expression to increase with germ cell differentiation from mouse and human ES cells by co-culturing with BMP4 - producing cells [57] and the addition of recombinant human BMP4 [6], respectively.

However, these germ cell marker genes are not appropriate for detecting germ cell differentiation from mouse and human ES cells because these genes are expressed in both ES cells and germ cells.

VASA is thus considered to be a valuable marker for the detection of germ cells in monkeys, as well as in mice and humans.

SSEA1 is a possible marker to detect ES cell - derived germ cells in monkeys, since its expression is found not only in primordial germ cells in vivo [55] but also in ES cell - derived germ cells in vitro in mice and humans [3], [56].

In conclusion, VASA is considered to be a valuable marker for detecting germ cells in monkeys, as in mice and humans.

CXCR4, which is a chemokine receptor, is expressed in migratory and post-migratory germ cells in vivo in mice [27], and is also a marker for germ cells derived from human ES cells [28], thus suggesting that CXCR4 is a candidate marker gene for detecting ES cells - derived germ cell in monkeys.

To do this, they colonized the intestines of germ - free mice with a synthetic human gut microbiota and exposed the mice to either a plant fiber - free diet or a plant fiber - rich diet.