Sentences with phrase «mouse and human skin»

Two studies demonstrate the first direct, chemical reprogramming of mouse and human skin cells into heart muscle and neural cells.

In findings appearing online today in Cell Stem Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene called Sox2 into both mouse and human skin cells.

Indeed, when the researchers engineered connective tissue cells from mouse and human skin to produce PRDM16 and C / EBP - beta, they became fully functional brown fat.

Mouse and human skin cells can be reprogrammed to hunt down tumors and deliver anticancer therapies.

Not exact matches

The study found that mice with peanut allergies developed similar symptoms as humans, notably itchy skin and breathing issues.

The team found neonatal mice with the mutations had normal - appearing skin, and the dry itchy skin of dermatitis did not develop until the mice were a few months old, the equivalent of a young adult in human years.

What's more, an ointment containing the peptide effectively treated wounds infected with methicillin - resistant Staphylococcus aureus (MRSA) and the increasingly common hospital infection bacterium Acinetobacter baumannii in mice and on laboratory samples of human skin.

After a few days, the cultured papillae were transplanted between the dermis and epidermis of human skin that had been grafted onto the backs of mice.

Similarly, the three research teams that last week reported turning mouse skin cells into embryolike cells say they will have to study embryonic cells to learn how to reprogram human cells in the same way and to understand their potential.

In the skin of the psoriasis mice, investigators first identified increases in stefin A1 (342.4-fold increased; called cystatin A in humans); slc25a5 (46.2-fold increased); serpinb3b (35.6-fold increased; called serpinB1 in humans) and KLK6 (4.7-fold increased).

Macrophages may live longer in humans than in mice, and the persistence of those cells might be responsible for preserving tattoos in human skin, he says.

The research, which was conducted in mouse models and human skin samples, could yield a way to combat sunburn and possibly several other causes of pain.

They separately injected six chemicals that make humans itch, such as histamine and the antimalarial drug chloroquine, under the mice's skin and noted how much the animals scratched.

In experiments with mouse and human hair follicles, Angela M. Christiano, PhD, and colleagues found that drugs that inhibit the Janus kinase (JAK) family of enzymes promote rapid and robust hair growth when directly applied to the skin.

Researchers report that high levels of salt in mice's skin help them fight off bacteria — and that humans may also stockpile salt at infection sites.

For both the mouse and human cadavers, skin and soil microbes provided good accuracy in predicting time of death, with a roughly a two - to - four - day error estimate over a span of 25 days, said Knight.

The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people.

The 19 NIH institutes, centers and offices contributing to the Knockout Mouse Project are: the NIH Office of Strategic Coordination / Common Fund; NCRR; the National Eye Institute; NHGRI; the National Institute of Allergy and Infectious Diseases; the National Heart, Lung and Blood Institute; the National Institute on Aging; the National Institute of Alcohol Abuse and Alcoholism; the National Institute of Arthritis and Musculoskeletal and Skin Diseases; the Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIDCD; the National Institute of Dental and Craniofacial Research; the National Institute of Environmental Health Sciences; the National Institute of General Medical Sciences; the National Institute of Mental Health; the National Institute of Neurological Disorders and Stroke; the National Institute of Diabetes and Digestive and Kidney Diseases; the National Cancer Institute; and the Office of AIDS Research.

«In mice that were treated throughout their lifetimes, researchers said they saw a remarkable delay in the development of cataracts, muscle wasting and the type of fat loss that, in humans, causes skin wrinkling.

Yamanaka's group used human adult skin cells and induced them to become iPS cells by having them produce the same protein factors that the mouse iPS cells had.

A few interesting articles in early life human microbiome, plus: A comparison between Staphylococcus epidermidis commensal and pathogenic lineages from the skin of healthy individuals living in North American and India; A new tool to reconstruct microbial genome - scale metabolic models (GSMMs) from their genome sequence; The seasonal changes in Amazon rainforest soil microbiome are associated with changes in the canopy; A specific class of chemicals secreted by birds modulates their feather microbiome; chronic stress alters gut microbiota and triggers a specific immune response in a mouse model of colitis; and evidence that the short chain fatty acids profile in the gut reflects the impact of dietary fibre on the microbiome using the PolyFermS continuous intestinal fermentation model.

While scientists have successfully reprogrammed different types of mouse cells (fibroblasts, liver and intestinal cells), skin fibroblasts were the only human cell type they had ever tried their hands on.

InvivoSciences makes engineered heart tissues from mouse embryonic stem cells and stem cells from differentiated adult tissues in humans, such as fat and skin.

They went on to show that Sox10, a factor needed for the formation of skin pigment cells from neural crest stem cells during development, was present at high levels in naevi and melanoma samples obtained from both the mouse model and human patients.

Jeyaraj and her colleagues studied smooth muscle cells derived from tiny blood vessels harvested from human skin biopsies and similar cells from mouse tail arteries.

Scientists grafted genetically edited human skin cells to treat type - 2 diabetes and prevent obesity in mice.

And while the human and T cells they studied in the laboratory were not specifically skin T cells they were isolated from mouse cell culture and from human blood — the skin has a large share of T cells in humans, he says, approximately twice the number circulating in the bloAnd while the human and T cells they studied in the laboratory were not specifically skin T cells they were isolated from mouse cell culture and from human blood — the skin has a large share of T cells in humans, he says, approximately twice the number circulating in the bloand T cells they studied in the laboratory were not specifically skin T cells they were isolated from mouse cell culture and from human blood — the skin has a large share of T cells in humans, he says, approximately twice the number circulating in the bloand from human blood — the skin has a large share of T cells in humans, he says, approximately twice the number circulating in the blood.