Sentences with phrase «mouse boosted the level»

She found that even a single dose injected into the SMA mouse boosted the level of SMN2 expression, though not enough for an effect on symptoms.

Not exact matches

Injecting live mice with the hormone similarly boosted levels of testosterone in their bloodstream.

That's because the boosted mice produced normal — rather than high — levels of the amyloid precursor proteins from which plaques are made.

And after a meal, mice's bones pumped out enough LCN2 to boost blood levels three times as high as premeal levels.

In the study recently published in Nature, Kousteni's team found that boosting LCN2 levels in mice missing the LCN2 gene tamed their voracious feeding habits.

Indeed, in mice, levels of the protein are boosted by a drug called rexinoid.

The researchers then decided to see what would happen if they boosted sirtuin levels in normal mice as they aged.

While these results have yet to be demonstrated in humans, recent research has shown that boosting tissue levels of NAD + can improve health and reduce metabolic complications in mice that have been fed a high - fat diet.»

The researchers boosted levels of a protein called α - CaMKII involved in memory storage and retrieval, just as mice recalled the pain of receiving a light shock.

In a study of mice, scientists from the David Geffen School of Medicine at UCLA discovered that boosting the animals» cholesterol levels spurred intestinal stem cells to divide more quickly, enabling tumors to form 100 times faster.

With thoughts of a jolt fresh in their brain, mice with normal levels of α - CaMKII froze up when they returned to the chamber an hour later, while mice with boosted levels remained calm.

«Scientists discover drug that increases «good» fat mass and function: Anti-cancer drug prevented weight gain and caused mice to burn more calories thanks to higher levels of metabolism - boosting brown fat.»

Through repeated stimulation with high - frequency bursts of light to the hippocampal memory circuit in AD mice, the team was able to boost the number of spines to levels indistinguishable from those in control mice.

Finally, the investigators showed that giving the chemical inhibitor to mice with high glucose levels also boosted glucose uptake in muscles.

This call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic straMouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic stramouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic strategy.

A placebo - controlled study showed that boosting the levels of the hormone artificially in mice may induce some of the benefits that would normally be caused by a workout.

The birth of new neurons in the mouse hippocampus starts waning in early adulthood — well before cognitive decline becomes obvious — so the researchers wondered whether boosting Tet2 levels in the adult hippocampus could restore neurogenesis and potentially prevent the onset of cognitive decline later in life.

Saghatelian and his colleagues had found that boosting the levels of one key FAHFA lipid normalizes glucose levels in diabetic mice and also reduces inflammation.

Additionally, genetic modification or pre-conditioning of autologous cells to boost the levels of VEGF [4], ANG [5], and TGF -[6], all previously linked to alleviation of ALS symptoms, could potentially lead to an augmented response, although this must first be assessed in animal models, such as the SOD1 mice.

Moving forward, the team will be looking for other drugs to test in mouse models of TB infection that can lower levels of miR - 33 to boost the pathways suppressed by TB through this tiny RNA.

Anti-cancer drug prevented weight gain and caused mice to burn more calories thanks to higher levels of metabolism - boosting brown fat

The authors found that «one week of treatment with a compound that boosts NAD + levels is sufficient to restore the mitochondrial homeostasis and key biochemical markers of muscle health in a 22 month old mouse to levels similar to a 6 month old mouse.

When the researchers fed the mice a drug that inhibits glutathione synthesis, however, dietary glutathione did in fact boost tissue glutathione levels, which shows that cells do have the capacity to absorb it.

Studies in animals and humans have shown that dietary glutathione increases blood levels of glutathione, but one study in mice suggested that under ordinary conditions, dietary glutathione can not boost its own concentration in other tissues except in the lung, where large amounts of glutathione are needed to maintain the fluidity of mucus.