Sentences with phrase «mouse brain level»

Thanks to Moore's Law, we're nearly up to mouse brain level.

Not exact matches

This region has the highest oxytocin levels in the brain and has high levels of oxytocin receptors across all species from mice to humans.

In The EMBO Journal, they reported that NAD levels decreased with age in the mouse hippocampus, a vital region of the brain for cognition.

The researchers discovered mice lacking ErbB4 have low levels of a particular neurotransmitter — GABA, or gamma - aminobutyric acid — in their brain.

In the study, led by post-doctoral fellow Long N. Nguyen of Duke - NUS, researchers found that mice without the Mfsd2a transporter had brains a third smaller than those with the transporter, and exhibited memory and learning deficits and high levels of anxiety.

«Brain cells from mice fed diets enriched with extra-virgin olive oil had higher levels of autophagy and reduced levels of amyloid plaques and phosphorylated tau,» Dr. Praticò said.

Dr. Schwarcz and his colleagues studied mice which were deficient in kynurenine 3 - monooxygenase, or KMO, an enzyme that is crucial for determining the levels of KYNA in the brain.

In addition, compared to mice on a regular diet, brain cells from animals in the olive oil group showed a dramatic increase in nerve cell autophagy activation, which was ultimately responsible for the reduction in levels of amyloid plaques and phosphorylated tau.

David Holtzman of Washington University School of Medicine in St Louis, Missouri, and colleagues found that beta - amyloid levels were higher in mouse brains when the mice were awake than when they were sleeping.

A mouse engineered to have Alzheimer's disease and a gradual reduction in levels of the brain enzyme BACE1 stopped forming plaques (arrows in the first panel) as it aged.

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.

Some of these mice were also engineered so that levels of the BACE1 enzyme, which is mostly found in the brain, gradually tapered off over time.

Alzheimer's mice with normal BACE1 levels experienced a steady increase in plaques, clearly seen in samples of their brains.

Studies in mouse models of HD showed that creatine raises brain ATP levels and protects against neurodegeneration.

A new study in mice, published in Cerebral Cortex, identifies increased levels of a specific neurotransmitter as a contributing factor connecting traumatic brain injury (TBI) to post-traumatic epilepsy.

In these mice and healthy controls, the time it took for levels of lactic acid in the brain to double correlated with how fast they aged.

One study published this year in Neurobiology of Aging, from researchers at the University of Southern California, examined brain changes in mice exposed to particulate air pollution at levels commonly found near freeways.

To investigate the longer - term effects of higher - than - normal acetylcholine levels on the brain, Hermona Soreq of the Hebrew University of Jerusalem and her colleagues first induced high levels of acetylcholine by forcing 26 mice to swim, an activity stressful to mice.

By getting down to synaptic levels in the brain — even if only in mice — the researchers seem to have taken a step toward explaining why omega - 3 trials in humans have shown some success in treating mood disorders.

In a paper published in Nature Immunology in 2011, Dr. Rostami and colleagues showed that the Th - 17 cells also produced another cytokine called GM - CSF, which created a chain reaction with another cell type ultimately increasing the GM - CSF levels in the brain of mouse models significantly.

Research coordinated by Osaka University has now shown that the nuclear protein complex cohesin must be expressed at sufficient levels in the early mouse brain to control gene regulation and allow development of healthy neuronal networks and behavioral characteristics.

By assessing the survival of the cells that engulf the particles and measuring the levels of red or green light that they emitted, the researchers determined which formulation of particles performed best, then tested that formulation in mice with human brain cancer derived from their patients.

The brains of mice genetically modified to lack normal prion proteins had significantly higher beta - amyloid levels.

«It was particularly exciting to see plasticity in the neurons impaired by mHTT,» said Davidson, noting that in the HD mice, brain areas that had begun to atrophy recovered volume and permitted better motor function after the researchers restored mTORC1 activity to more normal levels.

Mice lacking the HSF1 gene showed structural brain abnormalities and were prone to seizures after birth following exposures to very low levels of toxins.»

The mouse model mimics aspects of the infection in humans, with high levels of the virus seen in the mouse brain and spinal cord, consistent with evidence showing that Zika causes neurological defects in human fetuses.

«MHCI levels are altered in the Alzheimer's brain, and altering MHCI levels in mice disrupts memory, reduces synapse number and causes neuronal insulin resistance, all of which are core features of Alzheimer's disease,» Boulanger said.

Levels of A-beta in the blood of mice that received APOE2 were higher than in the other groups, suggesting that the protective variant had increased clearance of A-beta from the brain.

By labeling and collecting samples of Lynx1 and its precursors from the brains of mice at different ages, the researchers tracked how its levels changed over time.

The mice had symptoms such as abnormal brain function, impaired memory and high levels of either amyloid - beta or tau proteins in the brain.

As described in the paper, they found that levels of Zika virus in the mouse brain increased from day 3 to day 10 post-infection.

It uses computers to simulate the actual workings of an entire brain — a mouse's first, then a human's — all the way down to the biochemical level of the neuron.

Certainly, miRNA levels do not remain altered in the brain cells of mice injected with sperm miRNAs as zygotes.

Cellular - level changes to a part of the brain's reward system induced by chronic exposure to the psychoactive component of marijuana may contribute to the drug's pleasurable and potentially addictive qualities, suggests a study in young mice published in JNeurosci.

Now, experiments with rats and mice have shown that insulin increases dopamine levels by 20 % to 55 % in the striatal region, a brain area associated with pleasure and decision - making, according to a study published on 27 October in Nature Communications.

In a mouse model of Alzheimer's disease, Salk Institute researchers show that raising levels of neuregulin - 1 (right) lowers a marker of disease pathology in a part of the brain that controls memory compared with controls (left).

The reward center of the brain is much more attuned to the pleasurable effects of alcohol when estrogen levels are elevated, an effect that may underlie the development of addiction in women, according to a study on mice at the University of Illinois at Chicago.

In all, activity levels of dozens of genes in the brain were distinct between the two types of mice, they report.

In the new study, Lee's team tested this idea in a mouse model of Alzheimer's disease by raising the levels of one of two forms of neuregulin - 1 in the hippocampus, an area of the brain responsible for learning and memory.

In separate experiments in adult female mice with no pups — and hence no experience with elevated oxytocin levels — adding extra oxytocin into their «virgin» brains led these mice to quickly recognize the barely audible distress calls of another mother's pups recently removed from their home nest.

BDNF levels have also been shown to be reduced in the brains of individuals with Rett syndrome and in multiple brain areas of Mecp2 - deficient mice.

Importantly, levels of total tau and tau tangles in the brains of treated 12 - month - old mice were lower than in untreated 9 - month - old mice, suggesting that the treatment not only had stopped but reversed the buildup of tau.

The study found that after oral feeding, ground cinnamon is metabolized into sodium benzoate, which then enters into the brain, stops the loss of Parkin and DJ - 1, protects neurons, normalizes neurotransmitter levels, and improves motor functions in mice with PD.

While acute sleep deprivation is known to elevate brain beta - amyloid levels in mice, less is known about the impact of sleep deprivation on beta - amyloid accumulation in the human brain.

When the researchers measured the amount of virus present in different tissues, they found that, in addition to more virus in their blood and spleens, the older mice had 20-fold higher virus levels in their brains — which likely causes the excess deaths.

The group also found low levels of the proteins in tissues throughout the mouse body, supporting the theory that «each organ may have its own clock that might be coordinated with the main clock in the brain,» Sancar says.

With thoughts of a jolt fresh in their brain, mice with normal levels of α - CaMKII froze up when they returned to the chamber an hour later, while mice with boosted levels remained calm.

By studying brain samples from the mice, the researchers learned how neuregulin 3 works at the cellular level.

Researchers found that levels of neurotrophic factor (BDNF) nearly doubled in the brains of vulnerable mice, a finding that could point to a therapeutic target in humans for combating post-traumatic stress disorder and depression.

They injected pregnant mice with a chemical that simulates viral infection and found that their offspring did, indeed, show higher levels of the gene in their brain tissue.