Sentences with phrase «mouse brain slices»

In the Finkbeiner laboratory, Linsley uses time - lapse imaging of neurons in culture, within organotypic mouse brain slices, and within live zebrafish to uncover the mechanisms in neurodegeneration that lead to neuronal death.

Then they prepared mouse brain slices from a group of neurons in the dopamine production center, at 24 hours and every day thereafter.

Not exact matches

So Yang Shi and her PhD advisor, neurologist David Holtzman at Washington University were in for a surprise when they peeked at a set of brain slices from mice engineered to produce tau pathology.

Five years ago Viviana Gradinaru was slicing thin pieces of mouse brain in a neurobiology lab, slowly compiling images of the two - dimensional slivers for a three - dimensional computer rendering.

To create these cubes, Sebastian Seung of MIT and Daniel Berger, a postdoc in his lab, shaved 256 microscopically thin slices off the outermost layer of a mouse brain.

He then took slices of each mouse's brain and measured whether it led to an increase in the amount of electricity passing between neurons in the accumbens and the prefrontal cortex.

Next the scientists removed the mice's brains, separated out the amygdalas, sliced them thinly, and placed them on glass slides.

Hu's team then took brain slices from the mice in order to measure the electrical currents produced from mPFC neurons.

Scientists at the Allen Institute for Brain Science in Seattle are using microscopy to directly observe gene activity, one at a time, in razor - thin slices of mouse brain tiBrain Science in Seattle are using microscopy to directly observe gene activity, one at a time, in razor - thin slices of mouse brain tibrain tissue.

In this study, the researchers from Imperial's Department of Surgery and Cancer and the Royal British Legion Centre for Blast Injury Studies, applied xenon to slices of mouse brain tissue after exposing them to blast shockwaves that emulated those produced by improvised explosive devices (IEDs).

Studies of individual neurons in dishes of cultured neurons and in brain slices by co-first author Robert E. Stanley, a graduate student in the lab, revealed that neurons in the mutant mice had decreased numbers of dendritic spines, an important part of the synapses that neurons use to communicate with one another.

These findings were confirmed by two - photon imaging of neurons in the brains of living mice by the lab of collaborator Yi Zuo, PhD, a neuroscientist at UC Santa Cruz, as well as electrophysiological recordings from neurons in brain slices by the lab of collaborator Vikaas Sohal, MD, PhD, an associate professor of psychiatry at UCSF.

Spaced every centimetre along the film are tiny dots, each of which is a slice of mouse brain, one - thousandth the thickness of a sheet of aluminium foil.

Using electron microscopy to look at thousands of ultrathin brain slices taken from awake and sleeping mice, they found that after sleep, the size of most synapses — specifically, the surface area where two neurons touch each other — shrank by about 18 percent.

The mouse atlas was produced using a method called «in situ hybridisation», in which thin slices of brain tissue are bathed in a solution containing molecular probes that bind to messenger RNA sequences produced by each gene.

Digging for the root of the problem, the team experimented with slices of brain from the mutant mice.

Next, Südhof's team examined slices of brain tissue from the mutant mice.

Long - term goal of the project will be to visualize and manipulate tau expression also in a systemic context (organotypic slice preparations, mouse brain) by affecting the function of tau mRNA - containing neuronal granules as a potential drug target for the treatment of neurodegenerative diseases.

In addition to cultured cells, Ts1 - coupled nanoparticles were tested on complex brain tissue using thin slices of mouse hippocampus.

In order to characterize this possible imbalance, we performed in vitro brain slice whole patch - clamp recordings from the Q175 heterozygous knock - in HD mouse model expressing GFP under the control of the D2 receptor promoter to identify dSPNs (GFP - negative) and iSPNs (GFP - positive).

Chen Gu and his team obtained slices of brain tissue from dead mice.

And those same Abs would have to detect intracellular and axonal SN aggregates present in brain slices from synucleinopathic mice, but not to neurons from WT mice in vivo.

A study using mice found these high - energy particles slice through the brain.

We also have developed methods to visual cell type - specific de novo translation ex vivo in brain slices and in vivo in mice.

Analyzing brain slices of the mice, the researchers saw increased phosphates on the GluR1 receptors and an increased ability of these receptors to be recruited to synapses.

Postmortem brain slices can be «read» to determine how a mouse was trained to behave in response to specific sounds...