Sentences with phrase «mouse brain using»

«For the first time, we were able to directly monitor oxygen levels in human tumors growing in a mouse brain using EPR oximetry with implantable resonators,» explained Khan.

At 1 year of age, we counted the amount of SNpc dopaminergic neurons in the mouse brains using both colorimetric and fluorescent staining followed by unbiased stereology.

Not exact matches

The author discuses the dangers of pertussis and specifically that the same substance being used to cause brain inflammation in mice utilized for research.

One study found brain hemorrhages in mouse fetuses exposed to pulsed ultrasound at doses similar to those used on human babies.

The researchers then used genetic techniques to find out what would happen when NAD manufacturing is turned off in the adult neural stem cells of the mouse brain.

Using exquisitely precise methods to measure how memories are embedded in brain cells in mice, scientists have shown how fear - based memories prompted by the sound associated with an electric shock can be activated and erased.

The researchers are planning to use the novel mouse model to study how ErbB4 may coordinate brain activities, in an effort to learn more about mechanisms behind attention deficit disorders.

The experiment also showed that mouse brains are flexible enough to receive and make use of the additional wavelength information.

Alcino Silva, distinguished professor of psychology at UCLA, has been using genetic markers and a highly miniaturized microscope to zero in on sets of brain cells in mice with such interconnected or «linked» memories.

Research published in the October 21 issue of Science Translational Medicine uses a virus to deliver an extra dose of the gene p11 to the adult mouse brain.

Using a flexible mouse model, her team set out to determine whether anything could be done to restore memory «after a significant number of neurons are lost in the brain.»

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

The study used a novel mouse model to study brain functions.

Burd and her colleagues used a mouse model to study what happens to the brains of those offspring as they age into adulthood to see if the effects persisted.

Duke scientists have shown that it's possible to pick out key changes in the genetic code between chimpanzees and humans and then visualize their respective contributions to early brain development by using mouse embryos.

Dr. Erez and her team used mouse models to study and follow the spontaneous metastasis of melanoma in the brain.

Green and co-workers worked out a gentler approach using druglike molecules to kill microglia in the brains of mice with simulated Alzheimer's disease.

Using «freshman physics,» neuroscientists have deployed electric fields to stimulate neurons buried deep in the brains of mice — a method that could one day lead to noninvasive therapies for people with Parkinson's disease and other brain disorders.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

Other researchers have used optogenetics to transmit artificial skin sensations into the brains of mice, but Ko plans to investigate other technologies to find a technique that's best suited for his lab's e-skin.

Several research groups have tried to clarify this issue using various methods to clear microglia from the brains of Alzheimer's mice to see how this would affect amyloid buildup.

In contrast, the new method used on mice causes certain nerve cells to fire at a specific rhythm, generating brain waves that researchers believe may clear A-beta.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

The researchers used a technique called laser scanning photostimulation to map the connections between individual subplate neuron cells in the brains of the mouse pups.

Using fluorescent antibodies designed specifically to light up the receptor in mice, the investigators observed it on vagus nerves, which serve as a main biochemical connection between airway cells and the brain.

A dye used for more than a century to stain autopsied brain tissue can prevent the devastating effects of Huntington's disease in mice, new research shows.

Scientists made select nerve cells in mice's brains sensitive to light, and then used lasers to activate specific groups of those cells.

Using the supercomputers at Almaden and Lawrence Livermore National Laboratory, the group simulated networks that crudely approximated the brains of mice, rats, cats and humans.

The device uses brain signals generated in the motor cortex to control a computer mouse directly, allowing him to communicate.

This and subsequent similar experiments used guinea pig brains because they're larger and easier to work with than mouse brains.

«This study used humanized mice with tissue extracts directly inoculated into the brain, so the system was highly primed for infection.

They injected the particles directly into mice with an experimental human brain cancer, and into the brains of healthy mice for use as comparison.

Since the current work was done in mice, O'Leary and Zembrzycki want to confirm the link in humans by using brain scans to measure the natural variation in the neocortical areas and search for potential links to disease.

Click clock These days, new kinds of experiments using everything from computer simulations to brain scans to genetically engineered mice are helping unlock the nature of mental time.

To develop a comprehensive view of astrocyte gene expression, the duo used the technique in four very different areas of the mouse brain: two regions of the cortex and the hypothalamus and cerebellum.

They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts showed changes in gene activity in a brain region called the hippocampus as well as increased neural connections and enhanced «synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.

Scientists at the Allen Institute for Brain Science in Seattle are using microscopy to directly observe gene activity, one at a time, in razor - thin slices of mouse brain tiBrain Science in Seattle are using microscopy to directly observe gene activity, one at a time, in razor - thin slices of mouse brain tibrain tissue.

He targeted ChR2 to the sleep cells and then, using optical fiber, delivered light directly to the mice's brains.

To overcome these problems, Min and his team developed a new modality to visualize glucose uptake activity inside single cells based on stimulated Raman scattering (SRS) imaging, and demonstrated its use in live cancer cells, tumor xenograft tissues, primary neurons and mouse brain tissues.

This new combination of electronics and drugs to intervene in an individual brain circuit might be used to create mouse models of other mood disorders for other studies, Dzirasa said.

They did this by using a virus to load into the mice's brains extra amounts of another protein, called GADD34, which snips off the crucial phosphate from the eIF2alpha - P protein.

Using electroencephalography (EEG)-- in which electrodes placed in the brain measure neural activity — the team saw a sharp wave of action in the mouse brains from the hippocampus in the midbrain to the neocortex (the outermost brain layer).

The researchers also found that activation of ESP1 - responding neurons in the region of the brain called the hypothalamus enhanced sexual behavior in female mice, even in the absence of actual ESP1, by using various tools to chemically or optically control neural activities, combined with a process called the TRAP method, which allows them to selectively manipulate neurons responding to a particular stimulus.

We identified c - Jun amino - terminal kinase 3 (JNK3) as a binding partner of β - arrestin 2 using a yeast two - hybrid screen and by coimmunoprecipitation from mouse brain extracts or cotransfected COS - 7 cells.

While previous investigations into the protein's effects have used either mice in which gene expression was knocked out or transgenic animals that expressed human gene variants throughout their lifetimes, the MGH - MIND - led study used a different approach to investigate the effects of introducing the variant forms of the protein into brains in which plaque formation had already begun.

Over this span, the mice also showed a 2 - to 6-fold increase in global brain neuroinflammation using [18F] DPA - 714 PET imaging.

«We have successfully used cinnamon to reverse biochemical, cellular and anatomical changes that occur in the brains of mice with poor learning,» Pahan said.

For the first time, scientists have used Positron Emission Tomography (PET) imaging to study brain inflammation following Zika virus infection in mice, according to a study recently published online in the journal Molecular Imaging and Biology.

In the AlphaMed Press journal Stem Cells, Shah's team shows how the toxin - secreting stem cells can be used to eradicate cancer cells remaining in mouse brains after their main tumor has been removed.