It can efficiently introduce DNA into a cell to be incorporated into its genetic make - up, i.e. induce high gene expression level, especially in both human and
mouse breast cancer cell lines, and mouse breast cancer model.
Not exact matches
The research, conducted in
cell lines and
mouse models, explored enhancing the
cancer - killing effects of PARP inhibitors not only in regard to AML but also triple - negative
breast cancer.
Through these effects, the PERY peptide reduced the proliferation of several (but not all)
cancer cell lines in culture and inhibited the growth of a human
breast cancer xenograft in
mice.
In a four - year study conducted on the
mouse model in advanced
breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor
cells in the eye, but also extended the survival of experimental
mice bearing 4T1 tumors, a
cell line that is extremely difficult to kill.
In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in
breast cancer - derived
cell lines and in human
breast cancers replicated in
mice.
The researchers then injected AAV2 into human
breast cancer cell line - derived tumors in
mice without functioning immune systems.
Bottom
line While research has shown some benefits with regards to ER +
breast cancer cell death and prevention of metastases within
mice and cellular models, it is recommended that human intake should be through diet only, not supplementation.