Sentences with phrase «mouse cell experiment»

The SpaceX Dragon capsule's mission to the space station includes a clever mouse cell experiment that investigates how years of space flight affects humans

Not exact matches

It's only been tested on mice so far, but the results are tremendously promising for an antibody Stanford researchers have been experimenting with that blocks the body from «eating» cancer cells.

In our mouse experiments we have to inject cells that have the potential to become sperm back into the testes to help them finish developing.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

These experiments were complemented by genetic manipulations in which some mice were engineered to lack a gene known as Tap1, which is crucial for the MHC I complex to make its way to the cell surface.

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

Their next experiment, Coles says, is to transplant the cells into mice with degenerating retinas to see if they restore function and later to figure out how to activate and manipulate them.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

The experiments included sorting immune cells found at injury sites by molecules on their cellular surfaces, and many hours looking at mouse cells through the microscope.

After watching those mice thrive for several months, Lagasse repeated the experiment using fluorescent markers to trace the path of the liver cells.

The researchers performed further experiments in the mice to look for differences in the affected brain cells and the circuits in which they were connected.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiply.

In experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.

Those issues emerged 17 years ago, when a Stanford colleague of Greely's proposed implanting human stem cells into mouse brains to see what would happen when the former turned into neurons; the experiment has not yet happened.

In other experiments, the protein blocked the virus from infecting cells in culture, and it even prevented mice from getting sick when administered either 1 day before or after viral exposure, they report today in Nature Biotechnology.

They report their findings, based on experiments with cells and mice, in the September 2016 issue of Biomaterials.

The research team, Heller says, has already begun experiments to further explore the implications of these results, which include looking at differences in this pathway between cells taken from allergic and healthy individuals, and testing the efficacy of an inhalable drug that mimics the function of GRB1 and p70S6K to shut off the development of M2 macrophages in the lungs of mice.

To try to find out, in one experiment the researchers «knocked out» the production of VEGF in the amacrine and horizontal cells in mice before they were born.

In experiments with mouse ovaries inhibiting the identified enzymes saved the oocytes from cell death despite treatment with chemotherapeutics.

In a final experiment, the group gave the animals a compound that prevented LPA from binding to its receptor on mouse brain cells, right before they were injected with hydrocephalus - inducing LPA.

Lee conducted a real - time attempt to reproduce a controversial experiment published in Nature in which researchers claimed to have turned adult mouse blood cells into pluripotent stem cells.

When the hormone reaches the pancreas, it signals insulin - making cells to ramp up production, mouse experiments showed.

The two other mouse experiments, published in Cell Stem Cell and Nature, did document microcephaly.

In experiments on transgenic mice, teams at Harvard Medical School and Columbia University found that tau jumps from cell to cell in a predictable way along neural highways known as axons.

Experimenting with human cells and mice, Johns Hopkins researchers have found that a genetic mutation that alters a protein called NOD1 may increase susceptibility to human cytomegalovirus (CMV) infection.

Mallat hopes to clarify the role of regulatory T cells with a new experiment: injecting the cells into genetically normal mice with atherosclerosis, to see whether the cells can treat the disease.

Experiments in mice confirmed that 3BNC117 can accelerate clearance of HIV -1-infected cells in vivo, and clearance was also observed in T cells isolated from patients.

The researchers experimented with mice that were genetically engineered to have light - sensitive proteins on some of their nerve cells.

In another experiment, the research team transferred infection - combatting white blood cells — called neutrophils — from normal mice to genetically mutated mice.

Working with human breast cancer cells and mice, scientists at The Johns Hopkins University say new experiments explain how certain cancer stem cells thrive in low oxygen conditions.

The second key experiment showed the effect of transferring activated T - cells from heart - attack mice to healthy mice.

«Genome editing: Efficient CRISPR experiments in mouse cells: Researchers develop program for design of CRISPR RNAs and mouse breed especially useful for low - throughput screens.»

«In our experiments, our nanoparticles successfully delivered a test gene to brain cancer cells in mice, where it was then turned on,» says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of Medicine.

The first key experiment involved removing a specific subset of activated T - cells from mouse models.

Mice without Del - 1 that had been induced to get EAE also had significantly higher numbers of inflammatory cells in their spinal cords at the disease's peak, a fact that further experiments revealed was due to increased levels of the signaling molecule IL - 17.

Experiments with mouse fat cells (pictured) have turned up a protein that links diet and lifespan.

With careful observation and experiments with mouse oocytes, the precursors of eggs, they've detected molecular signals that create an asymmetry in the machinery that drives meiosis, the cell - division process that gives rise to gametes.

2 - D cell - culture and mouse experiments also provided key evidence of the virus's modus operandi; although the rodent brain doesn't harbor the full contingent of human neural stem cells, it has blood vessels and immune - system components that organoids lack.

The researchers ran numerous experiments in cell cultures and mice to observe what happened to Salmonella in the inflamed gut when these genes were mutated.

The experiments also left white blood cells cancer free for more than 30 weeks in live mice.

To validate their computer modeling predictions, researchers performed experiments in human cancer cell lines, mouse liver samples and primary human hepatocytes.

In experiments in mice and human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow — halted disease progression in bone marrow and spleen tissue within two weeks.

All of these findings were supplemented with several other experiments that were designed to learn how CHI3L1 interacts with other cells involved in the tissue repair response in both human and mouse lungs.

As with the previous experiment, all the transplanted cells were genetically identical to the mice in which they were injected.

Klebsiella pneumoniae is usually a normal resident in the mouth of healthy individuals, but as demonstrated in an experiment on specific pathogen - free mice treated and untreated with the antibiotic ampicillin, they can colonize in the gut and activate TH1 cells when antibiotics disturb the gut microbial balance and weaken tolerance for the colonization of oral bacteria reaching the intestine.

The experiment Orwig has in mind is to use gene - editing technology to fix this flaw in the sperm - forming stem cells and then transplant them back into infertile mice, thereby demonstrating a potential treatment for male infertility.

By performing experiments in petri dishes and with mice, they found that panobinostat, a drug designed to change the way cells regulate genes, may be effective at inhibiting DIPG growth and extending survival rates.

In experiments involving mice injected with human GBM cells, the scientists also demonstrated that if either PTEN or DAXX were eliminated, then tumor growth occurred.

In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells (Tregs; pronounced «tee - regs»), a type of immune cell generally associated with controlling inflammation, directly trigger stem cells in the skin to promote healthy hair growth.

In experiments with genetically engineered mice that lacked beta cells, reprogrammed stomach cells pumped out insulin and glucose at normal levels in the blood.