Sentences with phrase «mouse cell grafts»

Mice with human astrocytes performed better on memory experiments than those that had received mouse cell grafts, the team reports today in Cell Stem Cell.

Not exact matches

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

They mixed the cells into a jelly - like matrix and applied the grafts to mice.

A decade ago, he replicated the entire human leukemia disease process by introducing oncogenes into normal human blood cells, transplanting them into xenografts (special immune - deficient mice that accept human grafts) and watching leukemia develop — a motherlode discovery that has guided leukemia research ever since.

The team tested its technique on three mice whose abdomens had been grafted with cells from human brain cancer.

When grafted onto bald mice, the cells produced not only furry tufts but stretches of skin complete with the oil - producing glands that help keep it supple as well.

The researchers then extracted the cells and grafted them onto genetically engineered hairless mice.

The researchers found that PAI - 039 inhibited the migration of cultured human coronary artery smooth muscle cells, and prevented the development of blockages in arteries and bypass grafts in mice.

Researchers from Japan's RIKEN institute announced in April that they have grown skin from mouse stem cells in a process that one day may help skin graft recipients.

In tests on human breast cancer cells and in special immunodeficient mice with tissue grafts, the scientists found that both agents interfered with genes involved with breast cancer cell growth, resulting in more cancer cells.

To do this, they switched from using dead tumour cell samples to patient - derived tumour cell lines, in which fresh samples of a person's tumour are grafted onto mice and grown to the required volumes.

The research team tested the hypothesis by transplanting cells onto the surface of mouse bone grafts and studying the cell behavior both in vivo — inside the animal — and in vitro — outside the body.

A stem cell - derived neuron grafted onto a mouse cochlea in the inner ear that lacked neurons.

The current research team, which includes Dr. Minoda and Dr. Hiroki Takeda of Kumamoto University, and several researchers from Keio University, have successfully grafted human iPS - derived cells into the inner ear of embryonic mice, a feat with a high level of technical difficulty.

The team conducted investigations by grafting low - metastatic (LM) and high - metastatic (HM) melanoma tumour cells under the skin of mice.

The fact that Connexin 30 knockout mice had a higher number of grafted cells than normal mice, and that some of the grafted cells expressed CONNEXIN 30 is a very important finding when considering cell transplantation as a treatment for hereditary hearing loss caused by CONNEXIN deficiency.

Human egg cells behaved the same way; when human ovary tissue was grafted into mice injected with PAH, the eggs died, the team reports in Nature Genetics online this month.

However, the Connexin 30 knockout mice had more grafted cells than the normal mice, and some of the grafted cells were found to express CONNEXIN 30.

Furthermore, this study revealed that cells derived from humans can be grafted into the heterozygous inner ear of mouse embryos.

While humanized mouse models for HIV infection have utility, the model is limited due to incomplete immune reconstitution, development of xenogeneic graft versus host disease (GVHD), and the absence of normal T cell homeostasis.

As expected, xenogeneic graft versus host disease (GVHD), assessed clinically by dermatitis and hair loss, was observed in mice receiving cells treated with both R5 - ZFNs and X4 - ZFNs in the absence of HIV challenge.

However, closer scrutiny of these studies raises questions about the role of CD4 + T cells as the sole mediators of corneal graft rejection, as corneal allografts undergo immune rejection in 33 % of the mice and 64 % of the rats treated with anti-CD4 monoclonal antibody (12, 13) and in 45 % of the CD4 KO mice (14).

Short term T - cell mediated immune response blockade promotes the functionality of hESC - derivative grafts in immune - competent mice.

Support cells generated from patients with childhood onset schizophrenia stunted neural circuit development when grafted into developing mouse brains.

Creation of a rich subcutaneous vascular network with implanted adipose tissue - derived stromal cells and adipose tissue enhances subcutaneous grafting of islets in diabetic mice.

Scientists grafted genetically edited human skin cells to treat type - 2 diabetes and prevent obesity in mice.

Interestingly, when we looked at the splenocytes in these mice and compared them to controls, we were not able to detect a significant difference in the numbers of Tregs, suggesting that in the transplant model, Tregs may be within the graft - infiltrating population where they could regulate infiltrating host T cells.

To help determine how long a bone marrow (stem cell) graft will last, researchers at Sanford - Burnham Medical Research Institute (Sanford - Burnham) have developed a mathematical model that predicts how long a stem cell will live and tested those predictions in a mouse model.

Two new NSG mouse models allow immunological dissection of graft - versus - host disease (GVHD) responses and in vivo testing of therapeutic agents targeting human CD4 T cells.