Sentences with phrase «mouse cells reprogrammed»

Not exact matches

Mouse tumors injected directly with the reprogrammed stem cells shrank 20 - to 50-fold in 24 — 28 days compared with nontreated mice.

Mouse and human skin cells can be reprogrammed to hunt down tumors and deliver anticancer therapies.

Adding ascorbic acid to culture medium could help overcome the main roadblock in reprogramming human, mouse cells into iPS cells

Partial reprogramming of cells within prematurely aging mice's bodies extended the rodents» average life span from 18 weeks to 24 weeks, researchers report December 15 in Cell.

Ding's team took cells called fibroblasts from the connective tissues of mouse fetuses and bathed them in a cocktail of the four polyarginine - tagged proteins for 12 hours, then they removed the reprogramming proteins for 36 hours, and repeated this cycle four times over.

Scientists have rolled back time for live mice through systemic cellular reprogramming, according to a study published December 15 in Cell.

Research in mice and human cells suggests that a fasting - mimicking diet may reprogram pancreas cells that are unable to produce insulin and enable them to repair themselves and start making it.

«Our conclusion is that by pushing the mice into an extreme state and then bringing them back — by starving them and then feeding them again — the cells in the pancreas are triggered to use some kind of developmental reprogramming that rebuilds the part of the organ that's no longer functioning,» says senior author Valter Longo of the University of Southern California School of Gerontology and Director of the USC Longevity Institute.

Yet while alpha cells can reprogram into insulin production also in old mice, the ability of delta cells to do so is limited and does not extend beyond puberty.

When researchers suppressed the ARF gene in mole - rat cells during the reprogramming process to iPSCs, the cells stopped proliferation with sign of cellular senescence, while the opposite happens with mouse cells.

In mice, when adult cells are forced to fuse with stem cells, occasionally one of the adult cells reprograms itself, regressing back to an undifferentiated state.

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

The paper doesn't include any genetic analysis of the final eggs that confirms they are healthy, notes Mitinori Saitou, a stem cell biologist at Kyoto University in Japan whose team developed methods to create mouse egg cells from embryonic or reprogrammed stem cells.

2006 Shinya Yamanaka identifies and activates a small number of mouse genes in the cells of connective tissue, showing they can be reprogrammed to behave like immature stem cells.

Skin - producing cells called fibroblasts from the tip of an adult mouse's tail have been reprogrammed to make eggs, Japanese researchers report online October 17 in Nature.

In experiments with genetically engineered mice that lacked beta cells, reprogrammed stomach cells pumped out insulin and glucose at normal levels in the blood.

Professor Wolf Reik, Head of the Epigenetics research programme, said: «Charting the different developmental timings in the early reprogramming events observed in the human and mouse - derived cells gives the first mechanistic insight into how these events are regulated which is tremendously exciting.

The researchers used an adeno - associated viral (AAV) vector to deliver to the mouse pancreas two proteins, Pdx1 and MafA, which reprogrammed plentiful alpha cells into functional, insulin - producing beta cells.

Three separate groups reported in June that they had reprogrammed adult mouse skin cells into a form nearly indistinguishable from ESCs.

But when he injected the mice with genetically identical reprogrammed stem cells, their immune systems attacked, destroying the cells.

Similarly, the three research teams that last week reported turning mouse skin cells into embryolike cells say they will have to study embryonic cells to learn how to reprogram human cells in the same way and to understand their potential.

In 2006, Japanese biologist Shinya Yamanaka found a solution: He reprogrammed skin cells from a mouse, turning them back into embryo - like cells, with the potential to grow into any tissue, simply by adding four genes.

In 2006, Yamanaka took Gurdon's work to the next level by reprogramming adult mouse skin cells into induced pluripotent stem cells.

Three teams of scientists reported earlier this year that they had directly reprogrammed adult mouse skin cells into embryonic cells, although the process involved viruses and cancer - causing genes.

«Regenerative potential of cells in mouse retina: Researchers use a clue from zebrafish to discover the cues that reprogram Müller glia into retinal neurons.»

Cells reprogrammed in living mice (green) can contribute to both the placenta and body tissues of a developing mouse.

Researchers from the University of California, Berkeley, have found a way to reprogram mouse embryonic stem cells so that they exhibit developmental characteristics resembling those of fertilized eggs, or zygotes.

With this goal in mind, Dr. Divangahi's team vaccinated mice with BCG and in a series of experiments observed that in the bone marrow BCG was able to reprogram or «educate» the stem cells to proliferate and generate TB slaying macrophages.

Now, Dr. Divangahi's and Barreiro's teams have shown for the first time that when BCG, is administered to mice in a way that enables access to the bone marrow, it can reprogram stem cells.

They developed transgenic mice in which a specific drug can turn on the four reprogramming factors in all the animals» cells.

They also want to see if they can use a variation of the technique to reprogram human cells placed inside a mouse.

Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8 + T cells, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving cells.

That prospect brightened this week, with the announcement from a team led by Rudolf Jaenisch of the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, that dopamine - producing neurons grown from genetically «reprogrammed» mouse skin cells can ease Parkinson's - like symptoms in rats.

The study demonstrates that, when added to the Yamanaka cocktail to reprogram mouse fibroblasts, the duo TH2A / TH2B increases the efficiency of iPSC cell generation about twentyfold and the speed of the process two - to threefold.

Because tumor growth is a concern when cells are reprogrammed to an earlier stage of development, the researchers followed the mice in the Nature Cell Biology study for nearly a year to look for signs of tumor formation and reported finding none.

Scientists at the Massachusetts Institute of Technology (M.I.T.) report that they silenced symptoms of Parkinson's disease in rats using skin cells from an adult mouse that they reprogrammed to act like embryonic stem cells.

The work recently received a $ 1.7 million National Institutes of Health grant to delve into the mechanisms that occur as the cells reprogram, and to employ the cells for treating the Parkinson's - like symptoms in a mouse model of hypomyelinating disease.

Chimeric mice generated from cells reprogrammed for pluripotency (induced pluripotent stem cells, or iPS cells) show significant health problems, pointing to further challenges that must be overcome before such cells can be used in the clinic, noted iPS researcher Shinya Yamanaka said on Saturday (June 14).

It has recently been demonstrated that mouse and human fibroblasts can be reprogrammed into an embryonic stem cell - like state by introducing combinations of four transcription factors.

Our mouse study suggests that using a patient's reprogrammed cells could provide a route to personalised treatment of chronic inflammatory diseases, including progressive forms of MS

Dr. Srivastava's lab has leveraged the body of knowledge from cardiac developmental biology to reprogram non-muscle cells in the mouse heart directly into cells that function like heart muscle cells, effectively regenerating heart muscle after damage.

Initial reprogramming efforts used adult mouse limbal progenitors (epithelial cells which express Sox2, Klf4, and Myc) which the group reprogrammed to iPSCs using embryonic stem cell CM (ESCM) supplemented with MAPK and GSK3 inhibitors as previously described [4, 5].

In January 2008, he started his own group in ISCR and succeeded in making a non-viral single vector reprogramming system, which has been applied to both mouse and human cells using the piggyBac transposon in collaboration with Prof. Andras Nagy in Toronto (Kaji, et al., Nature, 2009, Woltjen, et al., Nature, 2009).

Yamanaka's initial work in reprogramming cells utilized mice, not human, embryonic stem cells, and he used the same method for human iPSC production.

In his laboratory mice, Dr. Ding has now used chemical reprogramming to turn fibroblasts into neural «precursor» cells with the potential to become new oligodendrocytes.

In mice, induced pluripotent stem cells created from fibroblasts have been reprogrammed to develop into both sperm and egg cells and have yielded healthy offspring.

«Instead we saw the reprogrammed cells integrate into the mouse's brain — and not a single tumor developed.»

Cell Stem Cell «Recently three different studies were published demonstrating that mouse fibroblast (skin) cells can be directly reprogrammed to behave like embryonic stem cells.»

Researchers successfully reprogram fertilized mouse eggs, producing both embryonic stem cells and cloned animals

To achieve efficient and synchronous reprogramming, the authors expressed reprogramming factors (OSKM) in mouse bone marrow - derived pre-B cells exposed to the C / EBPα transcription factor, leading to nearly 100 % reprogramming within 4 to 8 days.