The research team has been using NMR — a technique related to the one used in MRI body scanners and capable of visualising molecules at the smallest scales — to examine how small components of herpes virus help it to multiply by binding themselves with other large molecules; this produced images of a monkey herpes virus protein interacting with
mouse cellular protein and viral RNA.
Not exact matches
For instance, Evan's blue, a dye that stains the
cellular protein albumin, penetrates the brain 10 times more efficiently in stressed
mice than in unstressed
mice.
The laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in
mice the elimination of the Cdh1
protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents
cellular proliferation of rapidly dividing cells.
To accomplish this deception biologically, Bartfai and Conti genetically engineered
mice to overexpress uncoupling
protein 2, which causes the mitochondria in cells to produce heat instead of ATP, the fuel source of
cellular activity.
The new consortium proposes to characterize and tag the 1486 known transcription factors —
proteins that switch genes on and off — in the
mouse genome, as well as an estimated 600 coregulators that chip in to control
cellular and biological functions through networks called regulons.
Her research team found that
cellular oxidative stress (arising because of reactive oxygen species) increases in
mice exposed to THS, damaging
proteins, fats and DNA, and leading to hyperglycemia (excess glucose in the blood stream) and insulinemia (excess insulin in the blood)-- a condition also called insulin resistance.
Previous studies have found that if synthesis of certain
cellular proteins is blocked in
mice immediately after an event occurs, the
mice will have no long - term memory of the event.
In these
mouse lines, gene knockout can be induced by Cre recombinase expression while
proteins needed for later experiments (
cellular tracking for instance) can be controlled with FLP - FRT.
Analysis of
cellular localization of known actin cross-linking
proteins in
mouse melanoma B16F1 cells revealed that fascin was specifically localized along the entire length of all filopodia, whereas other actin cross-linkers were not.