Sentences with phrase «mouse embryonic cells»

Wondering why the third protein, an enzyme called p66, was not, despite being very similar to the other two, Pelicci's team knocked out the piece of the gene that enabled it to code for p66, in order to make mice and mouse embryonic cells that lacked p66.

Not exact matches

In a study in the journal Science, researchers explain how they used mouse embryonic stem cells and microchip technology to create heart muscle tissue that actually beats.

The ability of SIF - seq to use reporter assays in mouse embryonic stem cells to identify human embryonic stem cell enhancers that are not present in the mouse genome opens the door to intriguing research possibilities as Dickel explains.

The scientists rescued the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.

Repeated transfection of two expression plasmids, one containing the complementary DNAs (cDNAs) of Oct3 / 4, Sox2, and Klf4 and the other containing the c - Myc cDNA, into mouse embryonic fibroblasts resulted in iPS cells without evidence of plasmid integration, which produced teratomas when transplanted into mice and contributed to adult chimeras.

The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.

During the next 3 years, Lexicon will put high - throughput robots to work generating 500,000 mutant mouse embryonic stem - cell clones.

Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of mice.

The team inserted this «magnet» into mouse embryonic stem cells, next to a gene that promotes a protein called p16.

«Then, when you begin refeeding the mice, you see these embryonic - like cells begin to give rise to beta cells.»

Scientists have known for 20 years that SMN is necessary in every cell of the body, since disrupting the gene in a mouse causes early embryonic death, before muscle or nerve cells form.

So Harkany and his colleagues cultured mouse embryonic brain cells that expressed cannabinoid receptor proteins (CBRs) and exposed them to gradients of synthetic cannabinoids.

During embryonic development of mice, however, the situation is different: To build up the system, all mature blood and immune cells develop much more rapidly and almost completely from stem cells.

The team also found that ERAS, a tumorigenic gene expressed in mouse embryonic stem cells and iPSCs, was mutated and dysfunctional in the mole - rat iPSCs.

Scientists, with practice, have now been able to make nuclear transfer nearly routine to produce cattle, cats, mice, sheep, goats, pigs, and — as a Korean team announced in May — even human embryonic stem (ES) cells.

The only previous demonstration — by researchers led by Shou - Wei Ding, PhD, a professor of Plant Pathology and Microbiology at UC Riverside and co-corresponding author of the current study — was done in embryonic stem cells and in newborn mice.

In collaboration with Ding, the lab of Olivier Voinnet at the Swiss Federal Institute of Technology in Zurich also reported in an accompanying paper the detection of viral siRNAs in cultured mouse embryonic stem cells infected by the Encephalomyocarditis virus.

The research team used mass spectrometry to compare phosphorylation of proteins from mouse embryonic stem cells with fully functioning GSK - 3 to cells in which the gene encoding GSK - 3 had been deleted.

«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.

Mouse embryos: Scientists first found embryonic stem cells in mice in the 1970s, but an understanding of the critical role they play in cell differentiation only emerged years later.

Now you know that if you take a mouse embryonic stem cell that is, say, labeled so all of the developed cells will be blue, and you inject it into a mouse blastocyst, you'll get a chimera.

The paper doesn't include any genetic analysis of the final eggs that confirms they are healthy, notes Mitinori Saitou, a stem cell biologist at Kyoto University in Japan whose team developed methods to create mouse egg cells from embryonic or reprogrammed stem cells.

Starting in the mid-2000s, Yoshiki Sasai's team at the RIKEN Center for Developmental Biology in Kobe, Japan, demonstrated how to grow brainlike structures using embryonic stem cells, first from mice and then humans.

The scientists first compared mouse megakaryocyte cells created from embryonic stem cells engineered to lack p45 - Nfe2 with normal megakaryocytes.

Early in embryonic development, both mouse and human placentas rely on the same set of ancient cell - growth genes.

EYE CANDY Researchers grew primitive retinas (one shown, with proteins that collect and transmit light signals in green and red) by embedding mouse embryonic stem cells in a gel.

In the past few months, researchers in the United States and Japan have described a promising way of deriving embryonic stem cells from skin cells (of mice) without destroying embryos — the «Holy Grail of biotechnology,» as The Times of London put it.

• A team led by Ron McKay at the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland, turned mouse embryonic stem cells into isletlike cells, another step down the long road to a cure for diabetes.

One of the greatest came in November 2007, when scientists in Japan and the United States reported that they could make adult skin cells from mice revert to the embryonic state.

Beginning with mouse egg cells, Daley and his team tricked these egg cells, or oocytes, into thinking they had been fertilized (a process called parthenogenesis) and managed to isolate embryonic stem cells from the subsequent early mouse embryos.

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

A tooth grown from embryonic cells has been successfully transplanted into the jaw of a mouse.

Mice generated from embryonic stem cells in which ion channel genes have been mutated by homologous recombination often have a perfectly normal heart.

Using mouse embryonic stem cells that generate motor neurons as a model, the researchers found that CTCF isolates Hox genes from harmful activation.

Prior to joining GE, Dr. Hagner - McWhirter was a postdoctoral researcher at Uppsala University working with mouse embryonic stem cells.

The researchers confirmed Olig2's role in promoting motor neuron formation by increasing or blocking the function of Olig2 in the spinal cords of developing mouse and chicken embryos, as well as during motor neuron formation in mouse embryonic stem cells.

Renee Reijo Pera, a biologist at Stanford's Institute for Stem Cell Biology and Regenerative Medicine, points out that earlier attempts to create offspring with sperm from embryonic stem cells resulted in short - lived mouse pups that were either giants or midgets.

Similarly, the three research teams that last week reported turning mouse skin cells into embryolike cells say they will have to study embryonic cells to learn how to reprogram human cells in the same way and to understand their potential.

Working with mouse embryonic stem cells (mESCs), scientists at the IBS Center for RNA Research have come one step closer to understand how to control induced pluripotent stem cells.

When he injected mice with embryonic stem cells genetically identical to the mice's own tissues, the new cells thrived, growing into a large clump of adult tissues.

Imagine researchers» excitement, then, when Kyoto University's Shinya Yamanaka reported last year that his group had created embryolike cells directly, without transferring chromosomes, simply by injecting mouse fibroblast cells with four genes that are active in embryonic cells but not in adult ones.

In vitro experiments used human colon carcinoma cells with and without MMP9 and mouse embryonic fibroblasts, which are connective tissue cells that make the extracellular matrix and collagen and play an important role in tissue repair.

Manuel Eguren has analysed the biological consequences of Cdh1 elimination in rapidly dividing cells, as part of his doctoral research project in Malumbres's group; he focused on progenitors from the nervous system during embryonic development in mice.

All of the mice produced normal amounts of SOX2 during development, when the transcription factor plays a critical role in the genesis of embryonic and neural stem cells.

Mitchell and her colleagues eliminated this possibility when they deleted these nearby regions in the genome of mice and found there was no impact on the gene's ability to be turned on in embryonic stem cells.

When they transplanted embryonic brain cells into mice that had already been conditioned to fear a sound, the researchers found these mice were significantly more responsive to extinction training.

These are images of mouse embryonic stem cells which grow in a round colony of cells (A) and express Sox2 (B), shown in red.

«We studied how the Sox2 gene is turned on in mice, and found the region of the genome that is needed to turn the gene on in embryonic stem cells,» said Professor Jennifer Mitchell of U of T's Department of Cell and Systems Biology, lead invesigator of a study published in the December 15 issue of Genes & Development.

Other mice had implants of dead embryonic brain cells for comparison.

Yong - Chun Yu at Fudan University in Shanghai, China, and his team wondered if fearful adult mice could be helped by a transplant of embryonic brain cells.