Sentences with phrase «mouse embryonic development»
It is based on the definitive books of mouse embryonic development by Theiler (1989) and Kaufman (1992) yet extends these studies by creating a series of three dimensional computer models of mouse embryos at successive stages of development with defined anatomical domains linked by a stage - by - stage ontology of anatomical names.
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The aorta - gonad - mesonephros (AGM) region in the aortic wall appears to be the most important source of new blood cells, and it has been found to contain numerous hematopoietic stem cells by day 11 of mouse embryonic development.
Because bat experts think that the ancestor of all bats was a small mammal with short forelimbs like that of the mouse, the researchers next compared bat and mouse embryonic development.
The scientists rescued the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.
Not exact matches
«Our research on mice and rats shows that these chemicals affect the embryonic development of these animals.
The huntingtin gene is essential for embryonic development, and scientists have already shown that if mouse embryos don't have it at conception, they die in utero.
For this study, Guttridge, first author David J. Wang, who developed many of the study's concepts, and their colleagues monitored NF - kB activity during tumor development using mouse embryonic fibroblasts and two mouse models.
During embryonic development of mice, however, the situation is different: To build up the system, all mature blood and immune cells develop much more rapidly and almost completely from stem cells.
«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.
Early in embryonic development, both mouse and human placentas rely on the same set of ancient cell - growth genes.
Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.
«Observing the changes in the architecture of islets during embryonic development in mice and in pseudoislets — a model we generated in our lab — was also very interesting.
Manuel Eguren has analysed the biological consequences of Cdh1 elimination in rapidly dividing cells, as part of his doctoral research project in Malumbres's group; he focused on progenitors from the nervous system during embryonic development in mice.
All of the mice produced normal amounts of SOX2 during development, when the transcription factor plays a critical role in the genesis of embryonic and neural stem cells.
«We studied how the Sox2 gene is turned on in mice, and found the region of the genome that is needed to turn the gene on in embryonic stem cells,» said Professor Jennifer Mitchell of U of T's Department of Cell and Systems Biology, lead invesigator of a study published in the December 15 issue of Genes & Development.
To fill that gap, the researchers used mice to study the genetics behind embryonic development of the stomach.
What we do know is that in mice (and so, presumably, in humans) FOXP2 is active in the brain during embryonic development.
Animals as varied as grasshoppers and mice build their bodies by assembling repetitive pieces during embryonic development.
The next step, he says, is to investigate how embryonic mouse brains with induced folds develop as they mature past the fetal stages of development and to look across species to see if the gene has similar effects in other mammals.
To find out what these genes do, and which ones are master regulators of development, researchers have several approaches, including deactivating embryonic genes in mice.
They accomplished this by using mouse embryonic stem cells to manipulate the mouse genome at the very start of development.
As described in the journal Genes & Development, the researchers identified a new pathway controlling heterochromatin organisation in mouse embryonic stem cells.
In addition, this is not the only case in which the regulatory circuits that control early embryonic development in humans show greater similarity to those employed in bovine embryos than to those that operate in the mouse system.
The dynamin - related GTPase Drp1 is required for embryonic and brain development in mice.
A second method involves introducing the transgenic DNA into embryonic stem cells (ES cells) derived from a mouse embryo at the very early stages of development.
Anita Bledau (Anastassiadis, TUD)-- «SET Histone methyltransferases in mouse embryonic stem cells and mammalian development» (2011)
Correspondingly, endothelial - specific deletion of Tie2 using Ve - cad - Cre driver mice, pursued in validating the Tie2fl / fl mice used in this study, essentially phenocopied the global Tie2 KO phenotype with embryonic lethality around E10.5 (Supplementary Fig. 13), confirming the key role of endothelial Tie2 during embryonic development.
Professor Martinez - Arias and colleagues, supported by the European Research Council and the Wellcome Trust, have reconstructed these early stages of development using mouse embryonic stem cells.
Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors.
A switch has been discovered that instructs blood vessel cells to become blood stem cells during embryonic development in mice.
Mouse brain tissue from three different stages of the mouse brain development; embryonic day 15, postnatal day 2 and postnatal day 21, was stuMouse brain tissue from three different stages of the mouse brain development; embryonic day 15, postnatal day 2 and postnatal day 21, was stumouse brain development; embryonic day 15, postnatal day 2 and postnatal day 21, was studied.
Most Alkbh1 deficient mice die during embryonic development, and survivors are characterized by defects in tissues originating from the ectodermal lineage.
In this study, the team delved deep into the nucleus of cells belonging to mouse and zebrafish embryos — two important animal models of embryonic development — in order to determine how the Dll4 gene is turned on.
In view of the different timing of meiotic initiation in female and male mammals, we determined the developmental expression profile of mouse Boule during both male and female embryonic gonadal development (embryonic day 10.5, E12.5, E16.5 and E17.5) in comparison with adult gonads.
RT - PCR analysis of RNA from mouse embryonic and adult gonads using primers corresponding to either exons 3 and 9 (upper panel, 501 - bp band) or exons 3 and 12 (lower panel, 847 - bp and 712 - bp bands) reveals that full - length Bol1 is only expressed in postnatal testes, while Bol2 lacking exon 11 is also detectable at low levels throughout gonadal development in addition to its high adult testis expression.
Furthermore, the requirement of mouse Boule for male reproduction and its dispensability for female fertility suggests that low level expression of Boule in embryonic germ cells and adult ovaries is not essential for either the development of germ cells or the production of female gametes.
W. L. Leung, S. Y. Y. Wong, D. Chan, P. P. L. Tam, K. S. E. Cheah, Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain.
We show that DONSON is expressed in progenitor cells of embryonic human brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donson is essential for early embryonic development in mice as well, suggesting an essential conserved role for DONSON in the cell cycle.
It'll be tough for us not to continue down this road, in spite of some serious ethical questions, when most of what we know about human embryonic development comes from studying frogs, fish, chickens and mice.
96/3: 45 RNF12 is essential for X-inactivation in female mouse embryonic stem cells, is required for female mouse development, and might be a target for future therapies to treat X-linked disorders in females: Evidence from a mouse knockout model.
These genes normally guide embryonic heart development; however, in the adult mice hearts, they helped transform non-beating cells that form scar tissue into beating heart muscle cells.
It shows a mouse at embryonic day 10.5 and the expression of the Fezf2 gene in the developing cortical vesicles (in blue) at the start of brain development.
Mouse fetal development is perturbed by culture in low oxygen concentration that increases expression of oxygen - sensitive genes via hypoxia inducible factors: A non-epigenetic embryonic programming phenomenon?