Sentences with phrase «mouse embryonic stem cells»

Professor Elly Tanaka and her research group at the DFG Research Center for Regenerative Therapies Dresden — Cluster of Excellence at the TU Dresden (CRTD) demonstrated for the first time the in vitro growth of a piece of spinal cord in three dimensions from mouse embryonic stem cells.

Mouse embryonic stem cells with one allele of Melk inserted with lacZ and neomycin - resistance genes between exon 2 and 3 were obtained from the Knockout Mouse Project (KOMP; ID: CSD33136).

Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification.

These bovine iPSCs cells kept the normal karyotype and displayed dome shaped clones similar to mouse embryonic stem cells.

96/3: 45 RNF12 is essential for X-inactivation in female mouse embryonic stem cells, is required for female mouse development, and might be a target for future therapies to treat X-linked disorders in females: Evidence from a mouse knockout model.

Here we report that cultures of expanded potential stem cells can be established from individual eight - cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells.

Injection of mouse embryonic stem cells into blastocysts / Service Request form plus documentation.

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and the germline but are excluded from the extra-embryonic tissues that are derived from the trophectoderm and the primitive endoderm upon reintroduction to the blastocyst.

We also used it to study transition of mouse embryonic stem cells to a specific cell state of interest in Eckersley - Maslin et al Cell Reports 2016.

Here we characterise Myst2 / Kat7 / Hbo1 protein interactions in mouse embryonic stem cells by affinity purification coupled to mass spectrometry.

Electroporation of investigator - provided construct into mouse embryonic stem cells / Service Request form plus documentation.

InvivoSciences makes engineered heart tissues from mouse embryonic stem cells and stem cells from differentiated adult tissues in humans, such as fat and skin.

What she has shown is you can make mouse embryonic stem cells convert unidirectionally to trophoblasts by activating a single gene.

They made adult mouse cells become essentially mouse embryonic stem cells, in appearance and function, by forcing the adult cells to produce four key protein factors.

They made adult fibroblastic mouse cells become essentially mouse embryonic stem cells, in appearance and function, by forcing the fibroblasts to express four key embryonic stem cell factors: Oct - 4, Sox2, Klf4, and c - Myc.

With the new SIF - seq technique, mouse embryonic stem cells can be used to identify human embryonic stem cell enhancers even when the human enhancers are not present in the mouse genome.

Endogenous optical signals reveal changes of elastin and collagen organization during differentiation of mouse embryonic stem cells.

Researchers investigating signaling pathways which control pluripotency highlight newly found interactions and redundancies in mouse embryonic stem cells

Professor Martinez - Arias and colleagues, supported by the European Research Council and the Wellcome Trust, have reconstructed these early stages of development using mouse embryonic stem cells.

His thesis was entitled «Quantitative description of microRNA target site occupancy in mouse embryonic stem cells and derived cells of neuronal lineage.»

Nearly 30 years ago, two groups independently reported the isolation of mouse embryonic stem cells (mESCs)(Martin, 1981; Evans and Kaufman, 1981).

We are using mouse Embryonic Stem cells to understand how regulatory networks contribute to cellular decision - making processes in mammalian systems.

Studies of stable cell maintenance are being conducted in leukemia stem cells, hematopoietic stem cells, and mouse embryonic stem cells.

Anita Bledau (Anastassiadis, TUD)-- «SET Histone methyltransferases in mouse embryonic stem cells and mammalian development» (2011)

Giovanni Ciotta (Stewart, TUD)-- «Tagging methods as a tool to investigate histone H3 methylation dynamics in mouse embryonic stem cells» (2011)

Using mouse embryonic stem cells, they saw that the process involved three players — Pax3, p53, Mdm2 (Mdm2 being a protein that was already known to play a role in shutting down p53.)

Mouse embryonic stem cells stained for key pluripotency markersGRAZIANO MARTELLO Combining computer science algorithms with biological data has enabled researchers to create a model of the minimal number of factors necessary for mouse embryonic stem cells (ESCs) to self - renew in culture.

Expression of the Wnt inhibitor Dickkopf - 1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

We discovered that mouse mesenchymal stem cells (MSCs) can either fuse and form heterokaryons (cells with 2 nuclei) with mouse embryonic stem cells (ESCs) or can be invaded by ESCs through the entotic process (when one cell enters into another cell).

To appreciate the difference, consider that the old way involves introducing DNA into mouse embryonic stem cells, and then selecting for the rare cells that take up and incorporate the DNA in the right way.

Researchers identify a network of a dozen transcription factors needed to maintain the pluripotent state of mouse embryonic stem cells.

These are colonies of mouse embryonic stem cells, where cell nuclei are stained in blue.

As described in the journal Genes & Development, the researchers identified a new pathway controlling heterochromatin organisation in mouse embryonic stem cells.

«We aren't much wiser than we were a few decades ago» — when mouse embryonic stem cells were first isolated — said Harvard diabetes researcher Douglas Melton.

They accomplished this by using mouse embryonic stem cells to manipulate the mouse genome at the very start of development.

Mouse embryonic stem cells injected into rat brains express the AHD2 protein marker (yellow) characteristic of cells lost in Parkinson's disease.

Mouse embryonic stem cells were turned into something resembling spermatids, the round cells that mature into sperm, by Jiahao Sha of Nanjing Medical University in China and his team.

The team injected about 2000 mouse embryonic stem cells each into the brains of 25 rats who had previously had their dopamine - producing neurons damaged, which causes a characteristic tendency to move in circles.

Now, a new paper suggests that mouse embryonic stem cells can indeed accomplish this feat and lead to a partial recovery for animals with brain damage akin to Parkinson's.

Studying mouse embryonic stem cells, they removed Grb2, a protein essential to the ability of the stem cell to transform into other cell types, from the cells.

There is promising news today for those who hope to turn the potential of undifferentiated stem cells into medical miracles: Researchers are reporting a way to produce insulin - producing cells from mouse embryonic stem cells.

An ambitious plan to map the genome's regulatory elements will focus first on mouse embryonic stem cells.

The scientists already knew how to encourage mouse embryonic stem cells to express nestin, and they wondered if they could coax their nestin - positive cells to take on more characteristics of pancreas cells.

Smith and Martello plan to encourage mouse embryonic stem cells to turn into neurons, using Microsoft's formal analysis tools as a guide.

Researchers from the University of California, Berkeley, have found a way to reprogram mouse embryonic stem cells so that they exhibit developmental characteristics resembling those of fertilized eggs, or zygotes.

McKay announced that he had mitigated the symptoms of Parkinson's in rats by using mouse embryonic stem cells that he had turned into dopamine - producing brain cells.

The group inserted an algal gene that codes for a light - responsive protein into mouse embryonic stem cells.

These are images of mouse embryonic stem cells which grow in a round colony of cells (A) and express Sox2 (B), shown in red.

Working with mouse embryonic stem cells (mESCs), scientists at the IBS Center for RNA Research have come one step closer to understand how to control induced pluripotent stem cells.

The researchers confirmed Olig2's role in promoting motor neuron formation by increasing or blocking the function of Olig2 in the spinal cords of developing mouse and chicken embryos, as well as during motor neuron formation in mouse embryonic stem cells.