Sentences with phrase «mouse engineered»

They then tested these variants, along with regular insulin and long - acting insulin, in mice engineered to have an insulin deficiency.

They reached this conclusion during studies of mice engineered to build up protein fragments in their brains known to cause the disease.

When injected into mice engineered with a tau mutation that makes the protein clump abnormally in brain cells, triggering memory and motor problems, the antibodies reduced the clumping and improved the animals» behavior.

So Yang Shi and her PhD advisor, neurologist David Holtzman at Washington University were in for a surprise when they peeked at a set of brain slices from mice engineered to produce tau pathology.

In mice engineered without a muscle - building gene called IL - 15R - alpha, fast - twitch muscles in their front legs acted more like slow - twitch fibers.

For the study, the research team used mice engineered to lack CTCF specifically in germinal center B lymphocytes.

Researchers confirmed the connection this fall through tests on mice engineered to carry CD1a, according to Florian Winau, an immunologist at Harvard Medical School who was part of the study published in August in Nature Immunology.

Peter Scheiffele at the University of Basel, Switzerland, and colleagues used microscopes to view the developing brains of mice engineered so that individual neurons and their connections showed up in different colours.

Research confirmed their findings on lab mice engineered not to produce TRPA1.

In laboratory tests on embryonic mice engineered to not express myomerger in skeletal muscle, the animals did not develop enough muscle fiber to live.

The researchers studied mice engineered to develop plaques in their brains when the animals are about 10 weeks old.

Pregnant mice engineered to have higher levels of Zika virus had smaller fetuses (top) than normal dams (bottom).

First they decided to use a mutant mouse engineered to have very low levels of CREB, so that any behavioral effects of injecting extra CREB into the amygdala would jump out.

To answer this question, Cook - Andersen and her team worked with female mice engineered to completely lack the L2 protein only in their eggs.

Based on previous experiments that showed that α - CaMKII was important to a cellular phenomenon thought to underlie memory formation, Tsien's team bred mice engineered to make extra levels of the enzyme.

When mice engineered to develop ALS - like symptoms received AAV injections in their quadriceps and muscles behind their ribs, they lived 40 days longer on average than animals that did not receive treatment.

With the help of this grant, we are generating mice engineered to switch off the APOE gene only in microglia and performing molecular profiling without having to isolate microglial cells first.

Not so long ago, the advent of powerful genomic tools and genetic engineering techniques made it seem that studies involving mice engineered to carry human disease genes would be the best approach for exploring human disorders, superior to looking at cells isolated in a laboratory.

All nine of the new genes discovered had not previously been implicated in skeletal disorders and were discovered by randomly screening different strains of mice engineered such that a single gene had been inactivated in their genome.

Interestingly, transgenic mice engineered to harbor the KE family mutation in Foxp2 exhibit altered auditory brainstem responses [43].

In mice engineered so their macrophage cells would mimic those of people, expressing the human SIRPα protein, nanoparticles tagged with the CD47 peptide passports stuck around in the circulation rather than being gobbled up.

Chen removed the retinas from mice engineered to produce extra Bcl - 2.

Jardine et al. used mice engineered to express germline - reverted heavy chains of a particular bNAb and immunized them with an Env - based immunogen designed to bind to precursors of that bNAb.

Coussens and her U.C.S.F. colleagues Douglas Hanahan and Zena Werb reported in 1999 that mice engineered with activated cancer genes but without mast cells (another type of innate immune cell) developed premalignant tissue that did not progress to full malignancy.

The brains of mice engineered to develop Alzheimer's disease were riddled with these plaques, clumps of amyloid - beta protein fragments, by the time the animals were 10 months old.

Another experiment showed that mice engineered not to gain excess weight on the high - fat diet — and that therefore didn't have obesity - related inflammation — also had the regular amount of taste buds.

As part of the study, researchers found that mice engineered to develop symptoms of human inflammatory disease, and which also lacked the ATG16L1 gene, developed gut damage.

She latched onto the SCARB1 gene, inspired by a 2002 study in which MIT molecular biologist Monty Krieger found that mice engineered to lack that gene were more prone to heart attacks.

A mouse engineered to have Alzheimer's disease and a gradual reduction in levels of the brain enzyme BACE1 stopped forming plaques (arrows in the first panel) as it aged.

The number of plaques in the cerebral cortex per brain sample multiplied in mice engineered to have Alzheimer's.

Lab experiments have shown that NSAIDs reduce brain amyloid in mice engineered to mimic some disease features.

The new study found that vitamin C activated TET2 function in mice engineered to be deficient in the enzyme.

The scientists grew these cells in a petri dish and implanted them in mice engineered to be infertile.

While lab mice can live about 2 years, many of the mice engineered to overproduce this protein, called Klotho, have celebrated third birthdays.

In mice engineered to lack the protein, the abnormal connections remained, suggesting BMP4 is key to the trimming (PLoS Biology, DOI: 10.1371 / journal.pbio.1001013).

Six pairs of mice — with one mouse engineered to produce gobs of human A-beta and one normal — were surgically joined for a year, causing blood mingling that's far more extensive than that of a blood transfusion.

In five standard tests of impulsivity, such as showing boldness in exploring unfamiliar environments, mice engineered to lack a functional HTR2B gene were more impulsive than healthy mice.

Beginning 18 years ago, Bohn and her colleagues showed that, in mice engineered to lack β - arrestin2, morphine's pain relief was stronger and longer - lasting and its main side effects were dramatically reduced.

Mice engineered to make excess BH4 had heightened pain sensitivity even when they were uninjured, suggesting that BH4 is sufficient to produce pain.

Mice engineered to create no normal prions at all in their brains also produced far higher amounts than normal of the amyloid beta protein that causes Alzheimer's.

Mice engineered to express Lin28 in their kidneys developed Wilms tumor, which regressed when Lin28 was withdrawn, indicating that strategies aimed at blocking or deactivating the gene hold therapeutic promise for children with Wilms.

Moreover, mice engineered to generate smaller than normal quantities of SIRT1 carried relatively little fat in their blood, indicating that their cells hung onto it.

Most striking, he says, are results from mice engineered to make human amyloid ß.

They found that indeed, they do, and that stimulating these cells led them to kill cells infected with HIV - 1 derived from latently infected cells, both in culture and in mice engineered to have a human immune system.

Meanwhile Coussens and her colleagues at U.C.S.F. found in a 2005 study, published in Cancer Cell, that the removal of antibody - making B cells from mice engineered to be prone to skin cancer prevented the tissue changes and angiogenesis that are prerequisites for disease progression.

In a boost for a controversial theory of aging, mice engineered to make a human protein that sponges up cell - damaging molecules live 19 % longer than other mice.

The researchers also administered a compound to normal mice that blocked TRPV4, and found that inhibiting TRPV4 also led to smaller reductions in bite force, similar to the effects of the mice engineered without the Trpv4 gene.

In a related finding that year, Michael Karin and his collaborators at the University of California, San Diego, found that inhibiting NF - kB in mice engineered to develop colitis, which can lead to colon cancer, also promoted apoptosis.

In addition, harmine treatment tripled the number of beta cells and led to better control of blood sugar in three groups of mice engineered to mimic human diabetes.