Sentences with phrase «mouse epiblast»

Now, they're working to see if the MM - 401 eraser technique works with human stem cells that bear some resemblance to mouse epiblast stem cells.

Writing in the journal Cell Stem Cell, the team reports that more than half of mouse epiblast stem cells treated with the drug reversed course within three days, and regained an embryonic «be anything» state, also called pluripotency.

Until 2009, Saitou's starting point had been cells taken from a live mouse epiblast — a cup - like collection of cells lining one end of the embryo that forms at the end of the first week of development, just before the PGCs emerge.

Not exact matches

Niakan and colleagues predicted from earlier work with mice and human embryonic stem cells that the protein OCT4 would be necessary for the epiblast cells to develop correctly.

Similar observations have been made with respect to expression of stella in mouse ES cells, with stella positive cells, which resemble the inner cell mass, reversibly converting into stella negative cells which are more akin to epiblast [11].

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and the germline but are excluded from the extra-embryonic tissues that are derived from the trophectoderm and the primitive endoderm upon reintroduction to the blastocyst.

Here we show that exit from an unrestricted naive pluripotent state is required for epiblast epithelialization and generation of the pro-amniotic cavity in mouse embryos.