Sentences with phrase «mouse eye cells»

While investigating mouse eye cells, Botond Roska and his team at the Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland, noticed that one type behaved unusually in response to movement.

Not exact matches

Using the gene - editing tool CRISPR - Cas9 to turn off certain genes in a mouse zygote as well as other new techniques to enrich the pluripotent stem cells of a rat, the group managed to grow various rat organs (a pancreas, heart, and eyes) in a mouse embryo.

To figure out how the cells find their way from the eye to their final destination in the brain, Osterhout and her colleagues examined mice that had been bred to make green fluorescent protein, or GFP.

First she deprived juveniles of vision in one eye so that the corresponding brain cells failed to make connections; once the mice reached maturity, they were put in a water maze that required them to recognize a pattern of fine lines to find a floating platform.

EYE CANDY Researchers grew primitive retinas (one shown, with proteins that collect and transmit light signals in green and red) by embedding mouse embryonic stem cells in a gel.

Treating the potentially blinding haze of a scar on the cornea might be as straightforward as growing stem cells from a tiny biopsy of the patient's undamaged eye and then placing them on the injury site, according to mouse model experiments conducted by researchers at the University of Pittsburgh School of Medicine.

In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.

NERVE PROTECTORS The glowing cells in this micrograph of a mouse's optic nerve help shield electrical signals passing between eyes and brain.

In normal mice with working photoreceptors (PR driven), stimulating the retina produces a variety of responses in retinal ganglion cells, the output of the eye.

«We used a mouse model of the KPro to, first of all, identify the inflammatory factors that cause damage to the eye, and then we also quantified the amount of nerve cell death in the back of the eye that mediates the optic neuropathy, and, lastly, we looked at blocking these factors with antibodies,» said Reza Dana, M.D., M.Sc., MPH, Director of the Cornea and Refractive Surgery Service at Massachusetts Eye and Ear and the Claes H. Dohlman Professor of Ophthalmology at Harvard Medical School.

«Importantly, the investigation also demonstrates that newly generated cells in the mouse retina not only look and behave like neurons, they also wire correctly to the existing neural circuitry at the back of the eye.»

Cells within an injured mouse eye can be coaxed into regenerating neurons and those new neurons appear to integrate themselves into the eye's circuitry, new research shows.

The study, published in Cell Reports, involved giving cancer drugs to mice and inducing uveitis, an incurable autoimmune eye condition responsible for 1 in every 10 cases of visual impairment in the UK.

After testing the suppressive efficacy of the PshRNA agent in cultured cells, they injected it into the mouse's eyes.

«Our experiments indicate that after stem cell treatment, mouse eyes that initially had corneal defects looked no different than mouse eyes that had never been damaged,» Dr. Funderburgh said.

But three months after the lumican - deficient mouse eyes were injected with human adult corneal stem cells, transparency was restored.

Stem cells collected from human corneas restore transparency and don't trigger a rejection response when injected into eyes that are scarred and hazy, according to experiments conducted in mice by researchers at the University of Pittsburgh School of Medicine.

Importantly, 25 of the 115 transcripts, shared by EFTF - expressing pluripotent cells and the EF, encode for 15 genes that are both expressed in retinal stem / progenitor cells and required for normal eye formation in frogs, fish, mice, or humans (Figure 1C; Table S1).

The finding is based on studies of mice with altered levels of the growth factor PDGF in neural stem cells, which play a key role in the development of the eye.

With the excitement of a young doctor fresh out of medical school, Morales» eyes light up when he observes the petri dishes that harvest «celulas madre,» or stem cells, from mice.

Having discovered a genetic «key» (called P - TEFb) that is important in both cancer cell growth and immune cell differentiation, they tested the drugs on a mouse model for uveitis, an incurable eye condition in which the immune system mistakenly attacks healthy tissue leading to inflammation of the uvea (the middle layer of the eye).

The antibodies listed above in the immunocytochemistry section were also used on eye sections together with a cocktail of antibodies generated against human - specific markers (HSM) to identify human cells (the Oka blood group antigen, mouse TRA -1-85, 1 ∶ 10 (a kind gift from Peter Andrews, University of Sheffield, Sheffield, UK) together with mouse human nuclear antigen, 1 ∶ 1000, Millipore).