Sentences with phrase «mouse gene deletion»

Not exact matches

Initial testing of mTOR inhibition was achieved by direct deletion of the mTOR gene in mice.

Deletion of the CXCR4 gene led to sustained T - ALL remission within a month in similar mice, as well as movement of the cancerous blood cells away from the bone marrow.

The researchers were studying a well - established mouse model that forms a significant number of CCMs following the injection of a drug to induce gene deletion.

«Deletion of FAT10 gene reduces body fat, slows down aging in mice.»

Deletion of the GM - CSF gene in the mouse led to reduction and impaired regulatory function of gut tissue macrophages and dendritic cells which compromised induction of tolerance to food antigens and increased mice susceptibility to IBD.

Associate Professor Amanda Sainsbury - Salis expressed surprise at the impact of the Y6 gene deletion on mice, commenting «I find it amazing that one gene, which is expressed in the small part of the brain that controls the body clock, has such a profound impact on how much fat is stored on the body, and how much lean tissue is maintained.»

The first group was mice with targeted deletion of the interleukin 10 (IL10) gene, known as interleukin 10 knockout (IL10 - / --RRB- mice, which develop colitis through T helper immune cells.

It was then that they discovered the gene deletion had caused thin heart walls and other cardiac problems in developing mice embryos.

The researchers, led by Maria Luisa S. Sequeira - Lopez, MD, of UVA's Child Health Research Center, were investigating how the kidney forms when they noted that the deletion of the S1P1 gene in research mice had deadly consequences elsewhere in the body.

Mice engineered to carry a deletion of the Mstn gene have about a doubling of skeletal muscle mass throughout the body as a result of a combination of muscle fiber hyperplasia and hypertrophy [2].

She and Dingledine were able to dissect COX - 2â $ ™ s effects because they engineered mice to have a deletion of the COX - 2 gene, but only in some parts of the brain.

PER2: Deletion of the PER2 gene in mice, associated with the mechanisms of circadian rhythm, appears to improve DNA repair in stem cell populations relevant to the immune system, resulting in a healhier immune cell population, better immune function in old age, and a modestly extended life span.

Prior studies showed that this enzyme is produced early in the fracture healing process, and that deletion of the NOS2 gene delays healing in mice.

Much of the understanding of the function of members of the SEMA3 family has come from targeted deletion of these genes in mice (Sema3A, Sema3C, and Sema3F).

The MMRRC is your one stop resource for unique and popular research related mouse models offering specific gene deletions, insertions, modifications and repressions, and phenotypes.

We have identified a mouse containing a single base pair deletion in the Crb1 gene.

Effects of Bax gene deletion on social behaviors and neural response to olfactory cues in mice.

The team characterized the effects of the gene deletion and found that the mice had symptoms similar to those experienced by patients with BAD.

In Aim 1, we generate cell specific - knockout mice and characterize deletion of expression of distinct genes relevant to axon guidance.

Led by Karen Reue, the research team first used a mouse model that they had identified previously as having a spontaneous deletion in the Diet1 gene.

For each mouse line, Lexicon provided not only the mouse strain itself, but also detailed, objective data on the impact of the specific gene deletion on the mouse's phenotype, which includes appearance, health, fitness, behavior, ability to reproduce, and radiological and microscopic data.

ApoC - III ASO treatment lowered plasma TGs in mice lacking lipoprotein lipase (LPL), hepatic heparan sulfate proteoglycan (HSPG) receptors, LDLR, or LRP1 and in animals with combined deletion of the genes encoding HSPG receptors and LDLRs or LRP1.

For each mouse line, Deltagen provided the mouse strain, but also detailed, objective data on the impact of the specific gene deletion on the mouse's phenotype, which includes appearance, health, fitness, behavior, ability to reproduce, and radiological and microscopic data.

To investigate the underlying mechanisms, we undertook (1) bioinformatic, functional genomic annotation and human osteoblast expression studies; (2) gene - function prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead independent SNPs; and (4) analysis of gene expression in mouse osteoblasts, osteocytes and osteoclasts.

The form of polydactyly found in the hind limbs of this breed is similar to that observed in Alx - 4 knockout mice (18), and it has been shown that deletion of this PQn repeat (but not other portions of the protein) specifically destroys the ability of Alx - 4 to bind with lymphoid enhancer binding factor - 1 and drive target gene expression in limb bud mesenchyme (19).

A subsequent publication by Wilhelm and coworkers identified a deletion in the 3» end of the Klrd1 gene of DBA / 2J mice.

Studies on mutations of animals as varied as yeast, slime molds, plants and mice show that deletions of autophagy related genes (ATG) in animals is largely incompatible with life.