Sentences with phrase «mouse hematopoietic»

Researchers experimentally mimic the «Berlin patient» by creating an HIV - resistant selectable stem cell population which can reconstitute the mouse hematopoietic system and resist HIV infection

Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D, Waskow C. CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.

«We found that TRAF6 overexpression in mouse hematopoietic stem cells results in impaired blood cell formation and bone marrow failure,» said Starczynowski, a member of the Division of Experimental Hematology and Cancer Biology at Cincinnati Children's Hospital Medical Center.

While this difference was largely strain - dependent, it also reflected the fact that in the Rag2 − / − γc − / − mice hematopoietic space was greater than in the immunocompetent mice.

Not exact matches

The - / - mice had no overt hematopoietic abnormalities.

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

In this reconstituted schematic, hematopoietic stem cells (HSC) transplanted in a mouse model of Friedreich's ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneration.

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

When Busch turned on the marker in adult animals, it became visible that at least one third (approximately 5000 cells) of a mouse's hematopoietic stem cells produce differentiated progenitor cells.

To gauge the effect off the loss of imprinting control on the maintenance of the quiescent hematopoietic stem cell pool, Venkatraman analyzed the numbers of quiescent, active and differentiated hematopoietic stem cells in mouse bone marrow.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

One of the most popular models is the immunodeficient nonobese diabetic severe combined immunodeficiency (NOD scid) gamma (NSG) transgenic mouse line, which can be endowed with a humanized immune system using CD34 + hematopoietic stem cells.

Further testing in the laboratory dish showed that hematopoietic stem cells from the sleep - deprived mice responded less strongly than their peers to naturally occurring chemical signals that trigger cellular migration.

Employing the advanced technology of the Institute's Cytometry, Imaging and Histology centers, the researchers examined the relationship between megakaryocytes and hematopoietic stem cells in mouse bone marrow.

«We used different groups of mice, in which either the oestrogen receptor or RANKL was inactivated in hematopoietic cells or in mesenchymal cells, to be able to identify the target cells of the hormone.

C / EBPdelta deficiency sensitizes mice to ionizing radiation - induced hematopoietic and intestinal injury.

Artificial bones produce new blood cells in mice, obviating the need for irradiation to kill off resident hematopoietic stem cells in recipients.

Coordinated and unique functions of the E-selectin ligand ESL - 1 during inflammatory and hematopoietic recruitment in mice.

c - myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo.

Studies of stable cell maintenance are being conducted in leukemia stem cells, hematopoietic stem cells, and mouse embryonic stem cells.

HSV - sr39TK positron emission tomography and suicide gene elimination of human hematopoietic stem cells and their progeny in humanized mice.

C / EBPδ Deficiency Sensitizes Mice to Ionizing Radiation - Induced Hematopoietic and Intestinal Injury.

The aorta - gonad - mesonephros (AGM) region in the aortic wall appears to be the most important source of new blood cells, and it has been found to contain numerous hematopoietic stem cells by day 11 of mouse embryonic development.

STAP (stimulus - triggered acquisition of pluripotency) cells were thought to be engineered stem cells created when hematopoietic stem cells from the spleens of newborn mice were exposed to an acid environment, triggering their conversion from multipotent somatic cells to pluripotent - like stem cells.

[11] Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin - Burns N, Krager K, Ponnappan U, Hauer - Jensen M, Meng A, Zhou D. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

Topics and models to be covered include: nomenclature, basic mouse genetics, concepts of mouse model generation, approaches to working up mutant mice, role of pathologists at research institutions, systemic, hematopoietic, mammary, gynecologic, cutaneous, infectious and immune system pathology, embryology and cancer models.

Functional rescue of dopaminergic neuron loss in Parkinson's disease mice after transplantation of hematopoietic stem and progenitor cells, EBioMedicine, in press.

In this work, we transplanted hematopoietic stem and progenitor cells into the substantia nigra of brains of two different mouse models of Parkinson's disease.

When undergoing treatment for leukemia many patients require hematopoietic stem cell (HSC) transplantation to replace the blood stem... Continue reading Mice pave the way to a cord blood transplant advance

A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal - bone marrow: a simple and rapid method for the isolation of mouse central bone marrow.

To study their role in such disorders, we generated knock - in mice with hematopoietic - specific expression of Sf3b1 - K700E, the commonest type of SF3B1 mutation in MDS.

For example, earlier experiments by others revealed poor engraftment of ES - derived hematopoietic cells in Rag - deficient mice.

Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice.

On long - term monitoring, HPC - derived hematopoietic cells remained detectable in both the allogenic and syngeneic mice, albeit declining with time.

(B) The expression of MHC antigens by the chimeric hematopoietic cells was determined by flow cytometry in the Rag2 − / − γc − / − mice.

Functional rescue of dopaminergic neuron loss in Parkinson's disease mice after transplantation of hematopoietic stem and progenitor cells.

For example, we have no information about how these newly - generated HPCs will compete with autologous bone marrow cells for hematopoietic niches in the recipient mice.

Microarray profiling using the Affymetrix Mouse Genome 430 2.0 array, defines sets of genes that are specific to bone marrow - derived hematopoietic stem cells and their different immunological progeny.

Utilizing sophisticated genetically engineered mouse models, we will study how these conserved longevity pathways regulate the homeostasis and aging of adult stem cells, including hematopoietic stem cells, the adult stem cells that sustain all blood lineages throughout life.