Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D, Waskow C. CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of
mouse hematopoietic stem cells.
«We found that TRAF6 overexpression in
mouse hematopoietic stem cells results in impaired blood cell formation and bone marrow failure,» said Starczynowski, a member of the Division of Experimental Hematology and Cancer Biology at Cincinnati Children's Hospital Medical Center.
Not exact matches
«Transplanted
hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In
mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»
In this reconstituted schematic,
hematopoietic stem cells (HSC) transplanted in a
mouse model of Friedreich's ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneration.
Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype
hematopoietic stem and progenitor cells (HSPCs) into a
mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.
When Busch turned on the marker in adult animals, it became visible that at least one third (approximately 5000 cells) of a
mouse's
hematopoietic stem cells produce differentiated progenitor cells.
To gauge the effect off the loss of imprinting control on the maintenance of the quiescent
hematopoietic stem cell pool, Venkatraman analyzed the numbers of quiescent, active and differentiated
hematopoietic stem cells in
mouse bone marrow.
Earlier
mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as
hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.
One of the most popular models is the immunodeficient nonobese diabetic severe combined immunodeficiency (NOD scid) gamma (NSG) transgenic
mouse line, which can be endowed with a humanized immune system using CD34 +
hematopoietic stem cells.
Further testing in the laboratory dish showed that
hematopoietic stem cells from the sleep - deprived
mice responded less strongly than their peers to naturally occurring chemical signals that trigger cellular migration.
Employing the advanced technology of the Institute's Cytometry, Imaging and Histology centers, the researchers examined the relationship between megakaryocytes and
hematopoietic stem cells in
mouse bone marrow.
Artificial bones produce new blood cells in
mice, obviating the need for irradiation to kill off resident
hematopoietic stem cells in recipients.
Studies of stable cell maintenance are being conducted in leukemia
stem cells,
hematopoietic stem cells, and
mouse embryonic
stem cells.
HSV - sr39TK positron emission tomography and suicide gene elimination of human
hematopoietic stem cells and their progeny in humanized
mice.
The aorta - gonad - mesonephros (AGM) region in the aortic wall appears to be the most important source of new blood cells, and it has been found to contain numerous
hematopoietic stem cells by day 11 of
mouse embryonic development.
STAP (stimulus - triggered acquisition of pluripotency) cells were thought to be engineered
stem cells created when
hematopoietic stem cells from the spleens of newborn
mice were exposed to an acid environment, triggering their conversion from multipotent somatic cells to pluripotent - like
stem cells.
[11] Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin - Burns N, Krager K, Ponnappan U, Hauer - Jensen M, Meng A, Zhou D. Clearance of senescent cells by ABT263 rejuvenates aged
hematopoietic stem cells in
mice.
Researchers experimentally mimic the «Berlin patient» by creating an HIV - resistant selectable
stem cell population which can reconstitute the
mouse hematopoietic system and resist HIV infection
Functional rescue of dopaminergic neuron loss in Parkinson's disease
mice after transplantation of
hematopoietic stem and progenitor cells, EBioMedicine, in press.
In this work, we transplanted
hematopoietic stem and progenitor cells into the substantia nigra of brains of two different
mouse models of Parkinson's disease.
When undergoing treatment for leukemia many patients require
hematopoietic stem cell (HSC) transplantation to replace the blood
stem... Continue reading
Mice pave the way to a cord blood transplant advance
A quantitative assessment of the content of
hematopoietic stem cells in
mouse and human endosteal - bone marrow: a simple and rapid method for the isolation of
mouse central bone marrow.
Functional rescue of dopaminergic neuron loss in Parkinson's disease
mice after transplantation of
hematopoietic stem and progenitor cells.
Microarray profiling using the Affymetrix
Mouse Genome 430 2.0 array, defines sets of genes that are specific to bone marrow - derived
hematopoietic stem cells and their different immunological progeny.
Utilizing sophisticated genetically engineered
mouse models, we will study how these conserved longevity pathways regulate the homeostasis and aging of adult
stem cells, including
hematopoietic stem cells, the adult
stem cells that sustain all blood lineages throughout life.