Sentences with phrase «mouse hypothalamus»

Here, in samples of mouse hypothalamus — the brain center that detects and regulates internal temperature — Kun Song and colleagues identified neurons that were uniquely activated in response to warming at temperatures above the physiological set point of 37 °C.

The researchers were trying to identify genes involved in the development of the mouse hypothalamus, the area of the brain that includes the SCN.

Not exact matches

Oxytocin receptor in the Hypothalamus is Sufficient to Resue Normal Thermoregulation Function in Male Oxytocin Receptor Knockout Mice.

His team previously found that the hypothalamus, which releases hormones that affect other organs, seems to affect how mice age.

By interfering with a molecular pathway in the hypothalamus, the team extended the lifespan of mice by 20 per cent.

Injections of leptin in obese mutant mice cause them to reduce food intake and lose weight (and these injections work even if tiny doses are delivered directly to the hypothalamus).

Although stem cells in the hypothalamus create new neurons throughout life, the team noticed that mice start losing them in middle age — about 10 or 11 months old.

Injections of leptin in db mutant mice have no effect, because there are no leptin receptors in the hypothalamus for the exogenous leptin to activate.

P also enhanced phosphorylation of DARPP - 32 on threonine 34 in the hypothalamus of mice.

To visualize this activation, a needle - thin glass lens was inserted into the hypothalamus, and images of flashing neurons were recorded by a miniature, portable microscope attached to the mouse's head.

The activity of genes involved in cholesterol production in the hypothalamus — an area involved in the brain's energy maintenance — was reduced by 25 per cent in both groups of diabetic mice.

The authors suggest that higher levels of serotonin found in the hypothalamus of the SNCA mice may be associated with the reduced anxiety observed.

Eggen and his collaborators investigated the impact of high - and low - fat diets on inflammation and microglial markers in a specific brain region — the hypothalamus — of 6 - month - old mice.

Similar to zebrafish, mice in which Lef1 had been removed from the hypothalamus showed signs of anxiety, including being smaller and a reluctance to explore.

To develop a comprehensive view of astrocyte gene expression, the duo used the technique in four very different areas of the mouse brain: two regions of the cortex and the hypothalamus and cerebellum.

The mice had GNRH in their hypothalamus, suggesting that the mutated gene doesn't prevent the hypothalamus from making GNRH, but somehow prevents it from secreting the hormone, the two teams report in the 23 October issue of The New England Journal of Medicine.

The researchers also found that activation of ESP1 - responding neurons in the region of the brain called the hypothalamus enhanced sexual behavior in female mice, even in the absence of actual ESP1, by using various tools to chemically or optically control neural activities, combined with a process called the TRAP method, which allows them to selectively manipulate neurons responding to a particular stimulus.

In addition, researchers found that mice exposed to BPA before birth had reduced fiber density and brain activity in the hypothalamus circuits involved in regulating energy expenditure.

Newborn mice typically exhibit a surge of leptin when they are eight days old that programs the hypothalamus circuits to respond to fullness cues.

Other research has found that this gene, called SLITRK6, is active in the hypothalamus of male mice fetuses a few days before they are born.

While other types of neurons in the brainstem and hypothalamus have been shown to influence REM sleep, Dan said, «Because of the strong induction of REM sleep — in 94 percent of the recorded trials our mice entered REM sleep within seconds of activating the neurons — we think this might be a critical node of a relatively small network that makes the decision whether you go into dream sleep or not.»

Mice that had been denied food had 60 % less FTO in one part of their hypothalamus than did those that had eaten normally, hinting that FTO might play a role in appetite.

When the scientists took normal mice and temporarily reduced cholesterol creation in the hypothalamus with a technique known as RNA interference, the animals started eating more and gained significant weight.

When the researchers added GnRH to the hypothalamuses of old mice, they saw that it promoted adult neurogenesis.

The researchers measured NF - κB activation in mouse brains as they aged and noted that, while the protein was barely active in the hypothalamuses of young mice, it became increasingly active as the mice got older.

And, while the genetically - modified mice were made somewhat better by deactivating the HD gene in their hypothalamus, this approach isn't useable in human HD patients because their HD genes don't contain the sequences needed to turn them off with virus used by Petersen and colleagues.

New mouse work from Asa Petersen's group in Lund, Sweden, suggests that part of the brain called the «hypothalamus» might play a role in this symptom of HD.

In the Joslin study, scientists first examined gene expression in the hypothalamus of a mouse model of insulin - deficient (type 1) diabetes.

Follow - up studies in the mice could uncover more details about how a dysfunctional hypothalamus leads to depression.

But in BAC - HD mice, when the mutant Huntington's disease gene was turned off in the hypothalamus, the mice showed less signs of depression on one behavioral test.

His work in mice is currently focused on limbic circuits, including the amygdala and hypothalamus, and their role in aggression.

Using mouse recombineering techniques, she is working to unravel the complicated circuitry of the hypothalamus and connected brain areas involved in food intake behavior, neuroendocrine, and autonomic responses to stress.

Central hypothalamic insulin signaling interfered with negative feedback to the hypothalamus - pituitary - adrenal (HPA) axis in stressed male mice (151), which potentially explains high comorbidity rates of mental and metabolic disorders (see section V.P).

Cell death atlas of the postnatal mouse ventral forebrain and hypothalamus: Effects of age and sex.

For example, if the hypothalamus of a mouse doesn't recognize leptin, the animal will overeat, becoming obese.

Studies in mice have demonstrated that there are special types of neurons in the specific reproductive areas of the hypothalamus called kisspeptin neurons.