She is now looking at how
the mouse immune system attacks the parasite to see whether the host's response to the infection is the culprit.
Not exact matches
In Remodeling of the Mononuclear Phagocyte Network Underlies Chronic Inflammation and Disease Progression in Heart Failure: Critical Importance of the Cardiosplenic Axis, Prabhu and colleagues showed that
immune cells that are stored in the spleen were intricately involved in the heart failure that follows a heart
attack, or infarction, in a
mouse - model
system.
Now, thanks to the new
mouse model, it will be possible to study how renal tumors are able to develop in an environment with a normal
immune system, and how cancer cells manage to evade the
immune system's
attacks.
Scientists identified the specific proteins secreted by the parasite Toxoplasma gondii that cause the
immune system in
mice to
attack established ovarian tumors.
But when he injected the
mice with genetically identical reprogrammed stem cells, their
immune systems attacked, destroying the cells.
They found these lesions were as small as those in the CD74 deficient
mice, further supporting the hypothesis that the treatment was successful because it stops the
immune system from
attacking the brain.
In the new study, the researchers used a combination of four different therapies to activate both of the
immune system's two branches, producing a coordinated
attack that led to the complete disappearance of large, aggressive tumors in
mice.
ES cells from a 129
mouse, on the other hand, were unable to form teratomas in B6
mice because the animals»
immune systems attacked the cells, which they recognized as foreign.
By introducing a particular strain of bacteria into the digestive tracts of
mice with melanoma, researchers at the University of Chicago were able to boost the ability of the animal's
immune systems to
attack tumor cells.
The
mice had «humanized»
immune systems, Gage says, meaning that their
immune cells had been engineered not to
attack human tissue.
Although progress toward harnessing the
immune system to
attack tumors has been «enormous,» he said, his lab and many others are seeing in more and more studies — in lab
mice as well as patients — that «immuno - oncology» will not be as simple as stimulating T cells to
attack tumors.
Having discovered a genetic «key» (called P - TEFb) that is important in both cancer cell growth and
immune cell differentiation, they tested the drugs on a
mouse model for uveitis, an incurable eye condition in which the
immune system mistakenly
attacks healthy tissue leading to inflammation of the uvea (the middle layer of the eye).
November 5, 2015 Gut bacteria can dramatically amplify cancer immunotherapy By introducing a particular strain of bacteria into the digestive tracts of
mice with melanoma, researchers at the University of Chicago were able to boost the ability of the animal's
immune systems to
attack tumor cells.