Sentences with phrase «mouse immune system protein»

For the first time, scientists have witnessed a mouse immune system protein frisking a snippet of an invading...

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A decade ago a drug based on an internal protein of the flu virus, called NP (for nucleoprotein), set the immune system's killer T cells into action, but it only partially protected mice from the flu.

«Blocking immune system protein in mice prevents fetal brain injury, but not preterm birth.»

In tests in mice, a vaccine developed using human malaria parasite proteins — known as MSP -1-BBM — enabled the immune system to produce antibodies in the bloodstream.

They then injected the protein into elderly mice with normal immune systems, and found this reproduced the beneficial effects of cord plasma on both memory performance and LTP in the hippocampus whereas mice engineered to lack TIMP2 showed reduced LTP.

To explore these questions Akiko Iwasaki, professor of immunobiology and investigator of the Howard Hughes Medical Institute, and her co-authors observed replication of the Zika virus in the vaginal tissue of control, wild - type mice (genetically unmodified mice) and mice lacking genes that regulate immune system proteins known as type I interferons.

Because all the itchy mice had a defective version of the E3 ligase, Copeland suspects that their ubiquitin systems fail to tag immune - related defense proteins or foreign substances called antigens for disposal — both of which then might pile up and attract too many helper macrophages to the scene, wreaking havoc with the immune response.

Scientists identified the specific proteins secreted by the parasite Toxoplasma gondii that cause the immune system in mice to attack established ovarian tumors.

They systematically deleted genes for secreted effector proteins — molecules that the parasite injects into a host cell to modulate the immune system during infection — and injected the altered parasites into mice with aggressive ovarian cancer.

In 2004 a team at Trinity College Dublin tried to counter that reaction by injecting mice with parasites, giving the animals» immune systems the sort of threat they evolved to fight, thus distracting them from the food proteins.

However, endotoxin exposure did not stop mice lacking the A20 enzyme from becoming allergic to mites, showing that both the bacterial protein and the enzyme are needed to ensure the immune system did not overreact.

New research shows that all - trans - retinoic acid (atRA), the active form of vitamin A, regulates immune system responses in the mouse intestine by controlling expression of the protein HIC1 in cells known as innate lymphoid cells.

A University of Tokyo research group has discovered that pentatraxin 3 (PTX3), a protein that helps the innate immune system target invaders such as bacteria and viruses, can reduce mortality of mice suffering from sepsis.

The researchers noticed that in highly infected mice, NK cells produced IL - 10 about 3.5 days into the infection — days later than when they'd produce IFN - gamma, a protein that helps to mount, rather than defuse, the immune system response.

A series of biological analyses of the mice with Tim - 1 and immune cells isolated from human donors showed that Ebola virus directly binds to T - cells through Tim - 1 protein binding and causes massive inflammation that thwarts the immune system.

The malarial genes under the most intense selection pressure — those with the most variation, generated over a millennium - long cat - and - mouse game with the immune system's antibody response — are the ones that encode the identifying proteins on the surface of the parasite.

Using studies in both mice and humans, they found that exposure to farm dust increases expression of a protective protein that suppresses the inflammatory immune system by modifying the communication between the lining of the lungs and the immune system.

Was it the proteins in the bacteria, the sugar coat on the S bacteria, the immune system of the mouse or the nucleic acids RNA and DNA?

In their latest work, reported online in the Journal of Clinical Investigation, the scientists analyzed blood from such mice and identified two types of autoimmune response directed specifically against the protein, with the first response directed by a specialized kind of immune system cells called T cells and the second by antibodies.