Sentences with phrase «mouse infection model»

In a mouse infection model, lauric acid consumption decreased CDF - induced colon inflammation and diarrhea, supporting the hypothesis that lauric acid is a potential compound for CDF treatment.»

Prior experience in manipulation of anaerobic microbes, mouse infection models, analytical chemistry or bioinformatics are desirable (but not required).

Not exact matches

The resulting inoculation looks promising in both ferrets and mice, the most commonly used models of influenza infection.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

«Our research is the first to study Zika infection in a mouse model that transmits the virus in a way similar to humans,» explains Alysson R. Muotri, Ph.D., professor and director of the Stem Cell Program at UC San Diego and co-senior author of the study.

Virgin and his team decided to explore this possibility by studying a mouse model of chronic norovirus infection.

The researchers next established that 25HC is protective in mouse and monkey models of Zika virus infection.

«Immune molecule protects against Zika virus infection in animal models: Molecule also protects against Zika - induced microcephaly in mouse model.»

Based primarily at Harvard with Maniatis, tenOever developed a knockout mouse model to study a particular protein, IKKε, that's involved in the immune response to viral infection.

The mouse model should also be useful for studying the immunological reactions and viral clearance in hepatitis B virus infection, they note in the Journal of Virology.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Diseases.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

Using mouse models Dr Grainger and his team looked at how and where monocytes are programs in response to toxoplasmosis, an infection caused by a common parasite called Toxoplasma gondii.

Working with a mouse - model of parainfluenza virus infection, Sendai virus, which causes similar symptoms and patterns of tissue damage to RSV, researchers found that mice fared much worse in fighting the infection when their cells lacked IL - 27 signaling.

In human donor cells and mouse experimental models, the researchers demonstrated that TSLP specifically targeted neutrophils — white blood cells that constitute the first line of defense against bacterial infections.

Ultimately, the team wanted to build a model that could use a mouse's starting gut bacterial community to predict that mouse's risk of infection.

Realizing they might have a potentially effective drug on their hands, Bogyo and his colleagues brought in Sonnenburg, whose lab is adept at using mouse models of C. difficile infection.

While the mouse study does not prove a direct connection between Zika infection and microcephaly, Rossi said, it does underscore the urgent need for effective animal models to further study the course of disease and its transmission.

Efforts to combat the rapid spread of Zika virus got a boost this week as researchers at the University of Texas Medical Branch, Galveston (UTMB) announced the first peer - reviewed publication of a mouse model for Zika infection reported in decades.

«New mouse model to aid testing of Zika vaccine, therapeutics: Model mimics aspects of infection in people.&rmodel to aid testing of Zika vaccine, therapeutics: Model mimics aspects of infection in people.&rModel mimics aspects of infection in people.»

He had no animal model of the infection to use in his studies — rats and mice are not susceptible — so he famously used an experimental subject that did not require ethics approval or special funding: himself.

The mouse model mimics aspects of the infection in humans, with high levels of the virus seen in the mouse brain and spinal cord, consistent with evidence showing that Zika causes neurological defects in human fetuses.

«PET imaging tracks Zika virus infection, disease progression in mouse model.»

Specifically, Shresta's team created the first «sequential» mouse model mimicking dengue - then - Zika infection.

What's more, in a mouse model of M1 strep skin infection, it didn't matter if cathelicidin was present or not — the bacteria were just as virulent either way.

Last year, Diamond and others developed a mouse model of Zika infection that mimics the effects of the infection in pregnant women.

In mouse models of disease, Yale researchers looked at the effects of providing nutrients during infection and found opposing effects depending on whether the infections were bacterial or viral.

We also show that the strategy is effective in two additional mouse models, one representing acute infection in mouse cells and the other representing chronic, or latent, infection in human cells.»

She analyzes the comparative histopathology of genetically altered mice and models of human diseases, including cancer, inflammatory disorders, and microbial infections.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

Using a mouse model of UTI, the researchers showed that administration of HIF - 1alpha stabilizers directly into the bladder protected against UPEC infection.

In the study, the fungal infection Candida albicans was introduced to mice or human models of the lung vasculature and as blood was pumped over that system, researchers recorded what happened using highly sophisticated microscopes.

To study the still unknown pathogenesis of the disease, the researchers developed a mouse model susceptible to the full range of infection by the human parasite.

«Vaccine - inducedCD4 T cells lead to adverse effect in a mouse model of infection.»

Recently, many scientists came to suspect that a protein called NF - κB, a master regulator of infection and inflammation, was at work; in 1996, several groups had found that it also inhibited cell death, which can lead to tumor formation.To find out whether suspicions about NF - κB were well - founded, molecular biologist Michael Karin of the University of California, San Diego, and his colleagues turned to a mouse model of colitis.

Using a model of Parkinson's disease in which the toxin MPTP, made famous in book «The Case of the Frozen Addicts,» induces Parkinson's - like symptoms in humans and mice, Dr. Smeyne showed that mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.

The work was completed in mouse models that mimic infection, stroke or trauma in humans.

He hopes the animals will help him create more realistic mouse models of human chlamydia and salmonella infections.

Now, the Laboratory of Malaria Immunology Team at the Immunology Frontier Research Center (IFReC), Osaka University, headed by Professor Cevayir COBAN, have used mouse malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteoclasts.

To investigate this, researchers from San Diego State University, USA, led by Roberta Gottlieb and Ralph Feuer, first established a mouse model of mild juvenile CVB infection.

These enzymes are the first strategy that has ever been effective in eradicating mature biofilms, and that work in mouse models of infection,» adds Dr. Sheppard.

«Our results explain why post-exposure prophylaxis» — short - term treatment after exposure to HIV to reduce infection — «with antibodies is more effective than ART in our mouse models.»

While humanized mouse models for HIV infection have utility, the model is limited due to incomplete immune reconstitution, development of xenogeneic graft versus host disease (GVHD), and the absence of normal T cell homeostasis.

Thus, in an NSG humanized mouse model of HIV infection, the cells treated with X4 - ZFNs engrafted, trafficked, and persisted comparably to control cells.

The researchers compared their new mouse model with young mice that have immune system defects and are known to die several days after Zika infection.

«Because the mice used in this model have immune systems that allow them to survive initial infection, they could be particularly helpful for studying the long - term effects of Zika virus infection.»

Interferon - α / β signaling is pathogenic in a mouse model of congenital Zika virus infection.

Development of a mouse model of lung chronic infection to study disease progression after NTMs infection and response to novel antibiotic therapies.

D.K.V. Kumar et al., «Amyloid - β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease,» Science Translational Medicine, doi: 10.1126 / scitranslmed.aaf1059, 2016.