Sentences with phrase «mouse infectivity»

To demonstrate that the defective phenotype of ospC7 was due to the lack of OspC and to determine whether reintroduction of ospC was sufficient to restore mouse infectivity, we complemented the ospC mutation in ospC7 by integrating a WT copy of ospC adjacent to the mutated ospC gene on cp26 (Fig. 1).

Not exact matches

These models include in vitro experiments with purified recombinant or synthetic proteins, cell culture experiments, and infectivity studies with Tg mice expressing the appropriate form of the protein.

We further hypothesized that the fitness of persistent B. burgdorferi obtained from treated and untreated animals would be evident as differences in infectivity when injected into mice.

While the molecular results seemed to indicate dissemination of B. burgdorferi obtained from XT in SCID mice, we are hesitant to consider this evidence of infectivity, owing to the inconsistency of results.

Mouse models have provided key findings on pathogen infectivity and host responses to infection [21 — 25].

BB0844, an RpoS - Regulated Protein, Is Dispensable for Borrelia burgdorferi Infectivity and Maintenance in the Mouse - Tick Infectious Cycle

Piesman (23, 24) and Crippa et al. (25) showed that tick - derived spirochetes are physiologically different from culture - derived spirochetes and that infectivity for mice is enhanced with a tick - derived inoculum.