Sentences with phrase «mouse kidney cells»
They found that reducing the level of VEGF - A in mouse kidney cells caused kidney failure very similar to that seen in women suffering from preeclampsia.
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He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.
Single - cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
Two years ago, he and his colleagues reported in Aging Cell that cutting the calories ingested by mice by 30 % for up to 4 weeks protected the rodents» kidneys when their blood supply was cut off and then restored.
After giving the cells a week to get used to each other, the scientists implanted the chimeric concoction into the protective tissue surrounding the kidneys of living mice.
«Just one transplant of the human EPO - producing cells treated kidney anaemia in mice, keeping their haemoglobin levels in the normal range for the remaining 7 - month lifespan of the animals,» says Kenji Osafune, of Kyoto University in Japan, who led the team.
The team then transplanted these cells into the kidney cavities of mice with a form of kidney anaemia.
To demonstrate the capabilities of SpDamID in the current study, the authors analyzed Notch - mediated transcriptional activation in mouse kidney progenitor cells (mK4 cells).
Cells were transplanted to the kidney capsule and photo was taken two weeks later by which time the beta cells are making insulin and have cured the diabetes in the mCells were transplanted to the kidney capsule and photo was taken two weeks later by which time the beta cells are making insulin and have cured the diabetes in the mcells are making insulin and have cured the diabetes in the mouse.
The cells were implanted into an adult mouse, beneath a membrane that surrounds the kidney.
In the mouse study, the insulin - producing cells were placed under the kidney capsule — a thin membrane layer that surrounds the kidney — where they developed into an organ - like structure with its own blood supply.
Using cell models and genetically engineered mice, the authors then could reproduce kidney disease changes upon expression of APOL1 gene variants, but the disease required the presence suPAR.
To confirm that these cells were, in fact, stem cells, the scientists transferred them into the kidneys of adult mice.
«Mice engineered with rare kidney disease shed light on how cells repair broken DNA.»
In this cross section of a kidney from a young FAN1 knockout mouse, cell nuclei are stained purple.
In observing kidney cells from the FAN1 knockout mice, the researchers noticed that their nuclei were abnormally large.
Through studies conducted in mice, Oliver M. Steinmetz, MD (University Hospital Hamburg Eppendorf, in Germany) and his colleagues have shown that the messenger protein IL - 6, which is rapidly produced at high levels during an acute inflammatory form of kidney disease, potently dampens activation of tissue - destructive immune cells called macrophages.
«We isolated kidney progenitor cells from mice and searched for the most favorable culture conditions,» said Assistant Professor Shunsuke Tanigawa of Kumamoto University.
After transplanting the human iPS cell - based kidney tissue into a mouse body, glomeruli connecting to mouse kidney capillaries formed.
The team found deep conservation of certain processes that likely reflects similar underlying regulatory processes between mouse and man, but there were also significant differences in gene expression during kidney development, as well as in the timing, scale, organization, and molecular profile of key cell types and cell structures.
The test drug slowed the growth of kidney cysts in two mouse models and in cell cultures of human kidney cysts, the study showed.
«Our stem cells also survive outside of mice, in a culture, so we can also manipulate them in a laboratory,» said Abad, adding that: «The next step is studying if these new stem cells are capable of efficiently generating different tissues such as that of the pancreas, liver or kidney.»
«Massive single - cell survey of kidney cell types reveals new paths to disease: Study of over 57,000 cells from mouse kidneys help identify human renal disorders.»
Using mice bred to lack some types of lymphoid cells, among other features, researchers were able to show that those mice still had high levels of suPAR and proteinuria, indicating that lymphoid cells were not the perpetrators of kidney disease.
Four weeks after transplanting these cells into the kidney cavities of mice with a form of kidney anaemia, the treated animals had blood EPO levels 20 times higher than those in controls (Science Translational Medicine, doi.org/cdmx).
The study is published in the scientific journal Oncoimmunology and describes how a cell type in the blood, the neutrophil, causes kidney dysfunction in mice with cancer.
They showed that it slowed the growth of human lung cancer cells but not kidney cancer cells in these mice.
Rare stem cells (in red) that give rise to scar - tissue secreting myofibroblast cells, here found near the blood vessels of a mouse kidney (in green).
COS - 7 African green monkey kidney cells, C2C12 mouse myoblastic cells, MC3T3 - E1 human osteoblastic cells, and U-2 OS human osteosarcoma cells were obtained from ATCC.
In mice with kidney and cardiac fibrosis, the ablation of these cells resulted in reduction in fibrosis and rescued heart function.
The scientists got another surprise when they followed up on this finding with mouse experiments that exposed specialized kidney cells called «podocytes», a key component of the blood filtering, to high levels of glucose.
Recently, we showed that bortezomib treatment in mice bearing breast and kidney tumors provided host survival benefit by amplifying tumor cell caspase8 activation, CD8T cell effector molecules via increased NotchNFkB crosstalk and Fas ligandmediated lysis of tumor cells.
A new study establishes that the injection of a collagen - based biomaterial can mobilize endogenous stem cells to promote kidney regeneration in a mouse model
By age 2, the mice had some rat cells in their kidney, lung, pancreas, liver, and brain.
On the other hand, there are many other tissues — notably, the kidney and articular cartilage — where p16Ink4a - expressing senescent cells appear to be a contributing factor to human and murine degenerative aging, but which were not evaluated in treated or control mice in this study, and it would be of interest to see the effects of ablation of p16Ink4a - positive senescent cells.
Studying cells from the stomach and pancreas in humans and mice, as well as mouse kidney and liver cells, and cells from more than 800 tumor and precancerous lesions in people, the researchers found when tissue is injured by infections or trauma, mature cells can revert back to a stem - cell state in which they divide repeatedly.
Thus, upon activation by ActD, AKT becomes an inducer of p53 tumor suppression instead of being a survival factor, as consistently shown in human embryonic kidney cell lines (293 and 293T), human hepatoma cell line (HepG2), and mouse hepatoma cell line (Hepa - 1c1c7).