Sentences with phrase «mouse lines»

They advise other researchers to confirm observations in these mice with multiple techniques and describe alternative mouse lines that may be used instead.

Various mouse lines have been developed to express proteins that can be used to visualize changes in concentrations of calcium, which increase when neurons become active.

To guarantee the breeding, the production and the management of mouse lines in SPF conditions (Specific Pathogen Free) with all the related support services (decontamination, health status monitoring, cryopreservation, genotyping)

We have developed several new mouse lines in which translation initiation can be inhibited in an inducible and conditional manner.

The IMPC is a federation of phenotyping projects to carry out systemic phenotyping of mouse lines for each of the approximately 20.000 protein - coding genes in the mammalian genome in order to create an encyclopaedia of mammalian gene function.

The mice were crossed with Slc6a14 − / − mice to generate these two transgenic mouse lines on Slc6a14 + / + and Slc6a14 − / − backgrounds.

EMMA comprises over 6000 mutant mouse lines carrying targeted, transgenic, endonuclease - mediated, induced and other types of mutations.

The establishment of the genetically modified mouse line by breeding with the chimeric mice (Germ Line Transmission (GLT) of the mutation)

Utilizes spontaneous and CRISPR / Cas9 generated mouse lines along with primary cell culture models to look at the molecular intersection between the motor neuron and heart phenotypes in mouse models of Spinal Muscular Atrophy with Respiratory Distress (SMARD).

Initially, 251 lines were selected from the KO mouse lines developed by both companies.

Newly developed mouse lines will be expanded for the first line phenotyping.

«It just needs the Cre reaction to turn it on, and there are many mouse lines available that express Cre in different cell types.»

Wu's group is working on a more sensitive four - color reporter line, but until then, he also uses a two - color reporter mouse line called mTmG.

A comprehensive and secure set of services for the cryopreservation and recovery of mouse lines including importation, recovery, archiving, and distribution.

You can apply for the INFRAFRONTIER2020 mouse model development service to deliver novel mouse lines.

These efforts and investigations of new regeneration models — such as zebrafish and special mouse lines — are beginning to reveal the forces that guide regeneration and those that prevent it.

A massive effort known as the Collaborative Cross yielded 738 hybrid mouse lines by breeding an original eight strains of mice from three different subspecies, Mus musculus domesticus, M. musculus musculus and M. musculus castaneus (SN Online: 2/17/12).

For instance, using eight inbred mouse lines and their new statistical model, Valdar and Crowley's teams found that mice reacted to haloperidol in specific ways because they inherited certain genes from their mother or father.

Half of the mice studied, belonging to a genetic line that suffers a form of Crohn's disease were more affected than the remaining half of mice, which belong to a healthy mouse line.

To target the virus to GABAergic neurons, the researchers used a genetically engineered mouse line that expresses a marker protein in these specific neurons only.

To understand how heart muscle cells form trabeculae, Wu's team used a Brainbow mouse line called Rosa26 - Confetti.

Identification of a congenic mouse line with obesity and body length phenotypes.

Kristin Franke (Wielockx, TUD)-- «A novel conditional PHD2 deficient mouse line gives new insight into the interplay of oxygen and red blood cell production» (2012)

The research team on which she works has a unique mouse line wherein a particular gene (Bmal1) is overexpressed specifically in the skeletal muscle.

Sequencing of the mouse genome coupled with the successful development of transgenic and knockout mouse lines allows researchers to investigate the roles that individual genes play within specific mechanisms of renal physiology under both normal and pathologic conditions (14).

The transgenic mouse line APPswe / PS1ΔE9 85 was a generous gift of Dr. J.L. Jankowsky.

Conclusion: Our results indicate that two different HD mouse models have a similar deficit in response inhibition when tested on the peak interval task, although this deficit was not apparent in the BAC HD mouse line.

Development of innovative mouse lines by targeted genome modification (knockin - knockout (KI / KO) approaches).

In addition to the normal, reviewed submission process, individuals, institutions or consortia may arrange for the acquisition, importation, cryo - preservation and distribution of individual mouse lines or collections on a fee - for - service basis.

EMMA's commitment to cryopreserving mouse lines is at the core of its activities and underpins EMMA's support for the principles of the 3Rs: replacement, reduction and refinement.

Disease progression was compared in three knockin mouse lines with similar CAG repeat expansion lengths of approximately 190 repeats, were compared at 2, 4, 6 and 10 months of age utilizing PsychoGenics proprietary cubes platform technologies: PhenoCube ®, Smart Cube ® and Neurocube ® as well as standard behavioral testing paradigms including Open Field and Tapered Balance Beam.

AβPP transgenic mouse lines differ in the types and amounts of Aβ that they generate and in their spatiotemporal patterns of expression of Aβ assemblies, providing a toolkit to study Aβ amyloidosis and the influence of Aβ aggregation on brain function.

Tang wondered if he could use previously established mouse lines expressing GFP in specific cell types to do more than just label cells.

◊ tool to preserve mouse lines: November 22 - 24 in Orléans (CFE, PHENOMIN - TAAM) ◊ cryopreservation in mouse model: customized training in Toulouse (Anexplo) or in Lyon (AniRA)

The GEM Facility will thaw one straw of frozen embryos and culture overnight to the blastocyst stage to insure that embryo freezing is feasible for that particular mouse line.