Sentences with phrase «mouse lines for»

Generation and characterization of Neurod1 - CreER (T2) mouse lines for the study of embryonic and adult neurogenesis.

While these contract agreements are reviewed by the MMRRC's Coordinating Committee, the funding entity proposes the mouse lines for deposition at the MMRRC.

Fees for archiving a mouse line for distribution to the research community are based on the specific services requested and the estimated costs of importing, preserving and maintaining the strain at the facility.

Not exact matches

Mouse over lines for exact numbers.

both the fiber additives and the supplements FAIL to feed your microbiome, and instead, they CANNIBALIZE the mucus lining for fuel, at least for mice,

Surprisingly, both the fiber additives and the supplements FAIL to feed your microbiome, and instead, they CANNIBALIZE the mucus lining for fuel, at least for mice, according to this study.

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Introducing human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor cells to invade and grow in bone.

About three - fourths of the stem cell lines were found to be unsuitable for research, and many if not all the lines were contaminated with mouse feeder cells.

In healthy mice, normal sperm line up at the center of a part of the testes known as the seminiferous tubule, ready for release (left, arrows).

Although the researchers emphasized that laboratory results involving cell lines and mice do not necessarily translate to human treatment, they say their findings show that new mTOR inhibitors combined with chemotherapy could become a new treatment strategy for T - ALL.

Studying mice with injuries to the lining of the stomach, the researchers blocked the animals» ability to call on stem cells for help in the stomach.

To speed the search, the team had engineered a line of mouse cells to test for G - CSF - like activity.

For Chen and Birsoy, the next step in this line of research is to test the effects of ATPIF1 suppression in mouse models of mitochondrial dysfunction.

Coffin described how lab workers there had transplanted human prostate tumor cells into an immune - deficient lab mouse, a common procedure for procuring a colony of cells, or a human cell line, for further study.

Human tumor tissue or cell lines can be coengrafted into these mouse models, providing a powerful tool for studying the interactions between human immune cells and human cancers.

The causes of such unpredictable results, Harris said, can include bad ingredients in the lab, including contaminated and misidentified cell lines; poor research design, including insufficient numbers of mice in animal studies; statistical error and overreach, including «HARKing» (hypothesizing after the results are known), a push beyond the limits of the data; and funding pressures, which can lead scientists to hype or exaggerate their results to remain competitive for additional grant money.

Although Kato called human reproductive cloning directly from iPS cell lines «very hypothetical,» he pointed out progress for that possibility when he noted that three teams had produced mouse clones from iPS cells.

In the jargon, they are building the mouse «connectome», named in line with the term «genome» for the sequence of all of an organism's genes, «proteome» for all its proteins, and so on.

Furthermore, stem - cell lines from mice begin to lose their ability to produce many types of cells after as few as 20 generations, and researchers assume the same will prove true for stem cells from humans.

It seems to prime the mouse immune system for pregnancy, boosting an embryo's chances of implanting in the lining of the uterus.

«We set out to test this in cell lines derived from mice and humans, and came up with a result we definitely did not expect — which then led us to dig deeper for answers.»

The book is studded with explanations of common but uncelebrated objects — those dumbbells that hang from the undersides of power conductors (to absorb wind - induced vibration); the odd holes in barns (for owls invited in to eat the mice); and the colorful globes on power transmission lines that cross rivers (to alert pilots of tall - masted boats and low - flying aircraft).

Furthermore, for those who decide to pursue an academic career, all published reagents, such as knock - out mice and cell lines, are made freely available to take to their universities.

In their paper, Daley and colleagues report that the SNPs in the Korean cell line do indeed match toward the center of the chromosomes, similar to five parthenogenetic mouse cell lines that the team created for comparison.

The next steps in this line of research include tests on whether boosting the effects of FGF21 can help limit or reverse liver damage in mice and decrease a preference for alcohol in humans.

Tissue - specific microvascular endothelial cell lines from H - 2K (b)- tsA58 mice for studies of angiogenesis and metastasis

To overcome this, researchers from the University of Texas Southwestern Medical Center and Johns Hopkins University stabilized pri - miRNAs by expressing a dominant negative form of DROSHA, the RNase III enzyme responsible for pri - miRNA cleavage, in a variety of human and mouse cell lines.

I was able to establish a transgenic line from one of these founders (F66), and I backcrossed this line extensively to C57 BL / 6 mice for subsequent analysis.

Although the slopes corresponding to adipocyte cross-sectional area for the subcutaneous depot were smaller than (and fell outside the 95 % confidence intervals of) the slopes for the mesenteric and perigonadal depots, this difference was entirely attributable to the fact that the data from three B6.V Lepob / ob mice fell below the line relating adipocyte area to macrophage content in the other animals (Table 1).

Dotted lines represent values for wild - type C57BL / 6 mice.

Each of these four transgenic lines was backcrossed at least 6 times to C57 BL / 6 mice prior to analysis in order to control for genetic background effects.

In Tg mice lines, it is not uncommon for the phenotype to gradually soften over time, most likely by a decrease in the number of copies of the transgene.

The immortalized endothelial cell lines established from H - 2Kb - tsA58 mice provide, for the first time, a cell culture system to examine factors regulating angiogenesis and tumor cell arrest in different organ systems.

Consequently, 9 additional CreERT2 mouse lines will be generated by PHENOMIN team and will be made available as soon as possible for the scientific community.

We'll have a post that goes into the mouse genome editing process in a bit more detail in the coming weeks, but, in this post, we will outline a simple method for selecting the guide RNA, validating its efficacy in vitro, and using it in mouse embryos to generate gene modified mouse lines.

Investigating mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaMouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse models phenotyping imaging.

Historically, researchers have generated their own lines of knockout mice to serve as models for human disease, such as heart disease or cancer.

During the next five years, KOMP2 will transform the knockout mouse embryonic stem (ES) cells into adult mice for 2,500 lines of well - characterized knockout mice strains, and IMPC will create about 2,500 additional knockout mouse strains.

The phenotyping pipeline that will be used within INFRAFRONTIER - I3 builds on the EUMODIC pipeline and uses a cohort of seven female and seven male mutant mice for a comprehensive first - line phenotyping analysis.

The phenotype summarized above is for the parental line: Gad2 - IRES - Cre knock - in mice on a mostly C57BL / 6; 129S4 genetic background (Stock No. 010802).

Support attendees in use of European and international resources for mouse phenogenomics (cryopreservation, distribution and phenotyping data lines already characterized and available to the scientific community).

Depositors are asked to send mice of breeding age to the EMMA node to which the mouse line has been assigned to for embryo or spermatozoa cryopreservation.

Consequently, 45 additional new mouse lines will be generated by PHENOMIN team, in order to be available as soon as possible for the scientific community.

The scientists began with a line of mice in which the gene for the insulin receptor has been knocked out in endothelial cells only.

In their study Loeken and her group, including Yichao Wu, Marta Viana, and Shoba Thirumangalathu, used mice and cell lines to test their hypothesis that AMPK might be stimulated in the embryo and that stimulation of AMPK was responsible for blocking Pax3 expression and causing neural tube defects in response to high glucose.

It should be noted that the phenotype of this C57BL / 6J - congenic line (Stock No. 028867 Gad2 - IRES - Cre knock - in (C57BL / 6J)-RRB- could vary from that originally described for mice on other genetic backgrounds.

IHC - P mouse tumor tissue (from lung) with human cell line injected, some muscle tissue attached as well sees high background for human cellswith priamry Ab as well as isotype ctrl, but also for muscle (does not contain any EGF) Ab: 1 ug /...

A comprehensive and secure set of services for the cryopreservation and recovery of mouse lines including importation, recovery, archiving, and distribution.