Sentences with phrase «mouse macrophages»
"Mouse macrophages" refers to a type of immune cell found in mice. They are responsible for identifying and engulfing harmful bacteria and viruses in the body to help protect against infections. Full definition
In addition, morpholino antisense inhibition of NAIP5 activity in mouse macrophages from resistant mice resulted in an increase in permissiveness of Legionella replication (J: 129300).
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The MGH - based team conducted an RNA - interference - based genome - scale screen of mouse macrophages, selectively knocking down the expression of around 8,000 genes, and found that TREML4 — one of a family of receptors found on granulocytes and monocytes — amplifies the response of innate immune cells to activation via TLR7.
They show that highly purified NS1 acts as a pathogen - associated molecular pattern (PAMP) that activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) in culture via TLR4, resulting in release of inflammatory cytokines — an effect that was blocked by either a TLR4 antagonist or an anti-TLR4 antibody.
Protective antigen (PA)- Alexa647 at indicated concentrations: 0 ug / ml (red), 0.01 μg / ml (blue), 0.1 μg / ml (green), 1 μg / ml (orange) and 10 μg / ml (cyan) were used to determine the binding to ILC3 or RAW264.7 mouse macrophages.
No in vivo applicability was analyzed, but it can selectively inhibit MDP - promoted cytokine production in peripheral blood mononuclear cells and bone marrow — derived mouse macrophages.
By infecting susceptible mouse macrophages with S. Typhimurium and using global proteomics to analyze the proteins at various time points following infection, researchers identified 1,006 macrophage proteins.
Moreover, the researchers found that infective metacyclic stages derived from these promastigotes, which correspond to the parasite forms transmitted by sand flies, were unable to differentiate into amastigotes and multiply in mouse macrophages or cause cutaneous lesions in mice.
Recognized as the first global proteomic analyses of time course responses of mouse macrophages to S. enterica serotype Typhimurium (S. Typhimurium) infection, the study may lead to new strategies for diagnosing, treating, and vaccinating against infectious disease.
Amastigotes with such compromised mitochondrial function were unable to multiply in mouse macrophages (i.e. mammalian Leishmania target cells), suggesting that inhibition of LMIT1 can abolish parasite virulence.
Thousands of genes in fibroblasts and mouse macrophages, including those involved in inflammation, metabolism, apoptosis, growth, and differentiation are affected.