Sentences with phrase «mouse model based»

These experiments are innovative because they seek to improve a mouse model based on current knowledge from human disease, while also testing novel therapies that could be of benefit for affected individuals.

The Comparative Mouse Genomics Centers Consortium (CMGCC) was initiated by the National Institute of Environmental Health Sciences» (NIEHS) Environmental Genome Project to develop transgenic and knockout mouse models based on human DNA sequence variants in environmentally responsive genes.

Not exact matches

Based primarily at Harvard with Maniatis, tenOever developed a knockout mouse model to study a particular protein, IKKε, that's involved in the immune response to viral infection.

Using a combination of cell - based and mouse models, the researchers showed that the recently - evolved mycobacteria were more virulent, likely to cause more serious disease in patients.

Indeed, exposure of the protein produced by the nanoparticle - based gene therapy to the gut mucosa prevents inhibitor development and restores clotting - factor activity in mouse models of both haemophilia A and B. «This approach really could hold big benefit for patients,» says Jörg Schüttrumpf, a transfusion - medicine specialist who led one of the studies performed at the German Red Cross Blood Donor Service in Frankfurt.

Experiments in mouse models of Parkinson's disease and amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease) have demonstrated that Nrf2 - based neural protection is primarily conferred by astrocytes, but how neurons might alert astrocytes to stressful conditions is poorly understood.

Brain imaging research — in which scientists scan tiny mouse brains to understand neuroanatomical differences in autism models — has also revealed sex - based patterns.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

Injections of antibody molecules that block CD47 from interacting with SIRPA are already being tried in the clinic based on observations of some reduction in the sizes of tumors in mouse models.

«We have demonstrated the significance of this link in a mouse model system, based on the use of a miR - 34a - deficient mouse strain that we had generated.

The new study is based on the development of mouse models manifesting the disease that causes megalencephaly, spasticity and ataxia in humans.

Erben and his team based their study on the use of a special mouse model and new experimental methods.

Looking ahead, this newly generated mouse model offers far - reaching scope to study the molecular bases of hydrocephalus, a fairly common clinical condition in humans, where the causes are often unknown.

«CRISPR - based technologies have begun to revolutionize many aspects of cancer research, including building mouse models of the disease with greater speed and greater precision.

The immunologic basis of this finding appears to be related to an altered micro RNA network relevant for PD - L1 expression, similar to that observed in the NOD mouse model.

«There's been a lot of handwringing over the failures of drug trials based on findings from mouse models of Alzheimer's,» Dr. Small said.

Investigators from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute have developed an imageable mouse model of brain - metastatic breast cancer and shown the potential of a stem - cell - based therapy to eliminate metastatic cells from the brain and prolong survival.

Identification of a Maleimide - Based Glycogen Synthase Kinase - 3 (GSK - 3) Inhibitor, BIP - 135, that Prolongs the Median Survival Time of Ä7 SMA KO Mouse Model of Spinal Muscular Atrophy.

Corley also leads a $ 1.6 - million project that will be the first attempt to construct a physiologically based pharmacokinetic (PBPK) model for application to multiple species, including mouse and human.

Genetically - modified mouse models: pros and cons of nucleases - based technologies.

A new study establishes that the injection of a collagen - based biomaterial can mobilize endogenous stem cells to promote kidney regeneration in a mouse model

Dr. Jos Jonkers» research group studies the genetic basis of human breast cancer, using advanced mouse models for p53 - induced breast cancer, BRCA1 - and BRCA2 - associated hereditary breast cancer, and E-cadherin mutated invasive lobular carcinoma.

A CreER - based random induction strategy for modeling translocation - associated sarcomas in mice.

The model was based loosely on published work by (1) Surwit et al. (1995) and (2) West et al. (1995), in which a chow - based, undefined diets were used to study the DIO phenotype in inbred mouse strains.

PHENOMIN - ICS offers to generate genetically modified mouse models on a high - throughput and large scale basis, and then to provide a first phenotyping characterisation, either standardised or more specific, for a better understanding of disease mechanisms and for the development of new therapeutic treatments.

PHENOMIN - ICS services will ultimately help the scientific community in the use the mouse model, first to develop a complete functional annotation of the human genome and second to better understand human diseases and their underlying physiological and pathological basis.

Based on this observation, they developed a mouse model mimicking HIBM.

This research, funded by NIH, aims to test adenoviral recombinants based on simian serotypes for induction of immune responses to gag / pol / rev of HIV - 1 or SIV - 1 in a mouse model.

Results obtained with human samples will be substantiated with experiments in mouse models, including models based on genetically modified mice.

Using genetic and epigenetic analyses coupled with powerful perturbation technologies to test gene functions in human cells and mouse models, we hope to identify the critical drivers of this disease and the basis for therapeutic responses.

Access to the service will be granted on the basis of scientific excellence and supports the development and in depth characterisation of mouse models for research on ageing and age - related diseases.

A Ph.D. or M.D. / Ph.D postdoctoral position is available immediately at The Jackson Laboratory to study the genetic and molecular basis of retinal disease in mouse models.

Jefferson College of Pharmacy researchers are developing a new treatment approach based on nanotechnology that was recently shown to be effective in mouse models of the disease.

Previously we reported the development of liposome - based vaccines and their efficacy and safety in preclinical mouse models for tauopathy.

A second line of research is concerned with the development of etiological mouse models of schizophrenia, based on structural genomic variations found in patients.

We therefore suggest that the presence of the mutated transgenes (AβPP and PS1), which are per se the basis for the genetic form of Alzheimer's disease in humans, directly interferes with gut function as shown here for the disease model mice.

Using mouse and cell models we work to examine these diseases, their impact on homologous recombination and the molecular basis of these interactions.

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

It is based on the definitive books of mouse embryonic development by Theiler (1989) and Kaufman (1992) yet extends these studies by creating a series of three dimensional computer models of mouse embryos at successive stages of development with defined anatomical domains linked by a stage - by - stage ontology of anatomical names.

It improves access for the users of the INFRAFRONTIER Research Infrastructure by building capacities for systemic phenotyping, archiving and distribution of mouse models and by providing an efficient and transparent access process, based on peer - evaluated scientific excellence.

This research is based on mouse models and on translation to humans.

22) Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly - Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, DePinho RA, Kemp CJ, Varmus HE, Hanash SM (2011) Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.

We selected mice as the rodent species with which to prove this concept as they are a major agricultural, health and conservation pest, they are the most sophisticated animal model, and this knowledge base can be leveraged, and naturally occurring genetic elements known in mice but not other species can be exploited.

Our «biased» profiling is based on an in vitro model of mouse terminally differentiated myotubes, induced to re-enter the cell cycle by the E1A oncogene (23).

Lysogene collaborates with University of Massachusetts Medical School (UMMS) for pre-clinical efficacy studies of innovative AAV - based gene therapy approaches in the GM1 gangliosidosis mouse model.

The concept is based on previous work showing that similar compounds had positive effects on mouse models of the disease.

A study based on mouse models found I3C provided cardiac protection as it counteracted aspects of heart failure.

Eward, Fogle and their colleagues already have some evidence in support of this idea based on preliminary studies they've conducted in mouse models and cells in the lab.

Logitech says this model stems from the G100S Gaming Mouse used by eSports professionals, but relies on a re-engineered and optimized base design.

There is one caveat to that statement, however: per USB design specifications, USB - based keyboards and mice should draw less than 100mAh of power but many models disregard that specification and draw more.