Sentences with phrase «mouse model data»

In other words it becomes less clear what that spectra means if it can be induced by fresh air as well, its hard to inderstand why the control group gets dropped for the second part of the analysis, remember the majority of the study is in generating the mouse model data, and half that is the control group, its strange to sudden forget to include it in half the analysis.

Our mouse model data are not in conflict with the epidemiological observation that a first pregnancy before age 22 greatly reduces breast cancer risk (MacMahon et al., 1970), because at this young age, the chance of having already accumulated precancerous cells is small.

Harmonising ontological descriptions of phenotype in mouse and human and improving links between mouse model data and human data, using diabetes and obesity as examples, will increase the relevance of data that is generated in mouse studies for clinical studies.

Not exact matches

Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet on gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.

This is a highly limiting factor for research, because it complicates the annotation of data obtained by molecular techniques, and because it has been shown that gut microbiomes are to some extent specific to their host, and researchers have been using strains of other origin in mouse models.

And Duff's lab has unpublished data suggesting that trehalose lessens tau pathology and improves behavior in mouse models of neurodegeneration.

Data from in vivo mouse models indicate that delivery of the DMAb sequence for the influenza A-targeted monoclonal antibody protected against lethal doses of two very different, clinically relevant influenza A viruses.

Enormous projects such as ENCODE (for humans and mice) or modENCODE (for other lab model systems, such as the fly Drosophila or the worm C. elegans) have been devoted to collecting these data in order to analyse and interpret them in the framework of genomic data and to form hypotheses about functions and relations.

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet - B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

Provide example data from experiments using PD - L1 positive tumors and a cancer cell - line engraftment into a humanized mouse model that was used to test anti-PD1 immune therapy

After chronicling the different shifts of decomposers on the mice, and seeing the same shifts operating on the humans, the researchers built a computer model using the mouse data to see whether the microbial composition could be used to predict times of death, using the humans as a test case.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

These data suggest that increased inhibitory synaptic transmission may contribute to human ASDs and that the R451C knockin mice may be a useful model for studying autism - related behaviors.

They trained and validated the model using real - world data on tumor growth in mice.

This is a very popular mouse model in cancer studies, and we hope our data will aid research into cancer development.»

When Dr. Chen showed me her data identifying brown fat above the collar bone in mice, I was excited to collaborate and apply our transplantation model.»

One of the data sets came from researchers studying a mouse tumour model, to discover how the microenvironment adapts and responds to a tumour over time, both locally and in the draining lymph node.

Our data suggest that certain presumed null alleles, although unable on their own to support basal transcription, may in fact have a substantial impact on disease outcome in compound heterozygous humans, as they do in mouse models.

It provides a wealth of information on good practices in the use of mouse model (standardized techniques, ethics, regulations, analysis, data and resources...) to support attendees in their research.

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.

Mouse embryonic stem cells stained for key pluripotency markersGRAZIANO MARTELLO Combining computer science algorithms with biological data has enabled researchers to create a model of the minimal number of factors necessary for mouse embryonic stem cells (ESCs) to self - renew in culMouse embryonic stem cells stained for key pluripotency markersGRAZIANO MARTELLO Combining computer science algorithms with biological data has enabled researchers to create a model of the minimal number of factors necessary for mouse embryonic stem cells (ESCs) to self - renew in culmouse embryonic stem cells (ESCs) to self - renew in culture.

The lab will study mouse models of inherited RPE - driven disease, collecting and analyzing extensive genetic and physiological data throughout disease progression.

We will present data obtained with mouse models of autism, that demonstrate the utility of the system.

All data and mouse models from the project will be available to the research community.

«Our decision to procure these knockout mouse lines and data and make them available to the research community will yield tremendous benefits, both in the short and long terms,» said NIH Director Elias A. Zerhouni, M.D. «This trans - NIH initiative will place important mouse models into the hands of researchers, speeding advances in the understanding of human disease and the development of new therapies.

Our major resource development projects involve both data and biological resources for a variety of programs including the Mutant Mouse Resource and Research Center at JAX, the Special Mouse Strain Resource, the Mouse Mutant Resource and NICHD's Cytogenetic Models Resource.

«This is an interesting paper presenting a potentially useful preventative therapy for Alzheimer's disease but, while mouse models are very useful, we have to be very careful about the interpretation of the data in relation to the human condition.

For this study, Jabri and colleagues combined insights and data from celiac disease patients who had been cared for at the University of Chicago's Celiac Disease Center with experiments using a mouse model of the disease developed in her lab.

Although the Badovinac study does mention that immunization of B6 Prf1 − / − mice followed by LCMV infection results in mortality with LCMV - specific CD8 T cell expansion (as do naive B6 Prf1 − / − mice), these data were not shown as the focus of the report was on the BALB / c model.

In light of these findings and our data reported here, we believe that a new non-cyst-centric model of T. gondii - mediated behavior manipulation of the mouse intermediate host is warranted.

AFF 1: Preclinical Efficacy Data AFF 1 was then tested for preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to LBD than PD.

Standardized exploration of physiological functions, scientific and ethical considerations, study design, analysis and data management, alternative imaging method tests / Preclinical approaches with mouse models, a first step toward the man, interest and limits

The school will provide a wealth of information on good practices in the use of mouse model (experimental design, ethics, regulations, analysis, data and resources...) to support attendees in their research.

Gardiner says her group is now looking at data from a similar experiment done with a mouse model of Down syndrome.

Dr. Kothary also presented his own lab's unpublished data from a novel mild mouse model of SMA.

These data indicate limited benefits of exercise in the progranulin - insufficient mouse model of frontotemporal dementia without normalization of progranulin levels.

To help resolve the conflicting data, Joslin scientists conducted studies with a unique mouse model developed by Dr. Kissler's graduate student and co-author, Peilin Zheng.

This pilot will focus on mining available datasets for microbiome signatures as well as collating data from mouse models.

Simulated field trials will generate data on select mouse types, enabling mathematical models to be generated to predict outcomes and identify optimum release numbers and the most appropriate mouse type.

The INFRAFRONTIER Research Infrastructure provides access to mouse models, data and scientific platforms and services to study the functional role of the genome in human health...

That led the way for Pascal and others — who had done some beautiful work in mouse models — to generate comparable data sets.