Sentences with phrase «mouse model developed»

December 14, 2015 Brain cell death is a possible trigger of multiple sclerosis Multiple sclerosis (MS) may be triggered by the death of brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model developed by scientists from the University of Chicago and Northwestern Medicine.

To help resolve the conflicting data, Joslin scientists conducted studies with a unique mouse model developed by Dr. Kissler's graduate student and co-author, Peilin Zheng.

The study focused on embryonal rhabdomyosarcoma caused by mutations in the Sonic Hedgehog signaling pathway and used a mouse model developed in Hatley's laboratory.

To determine how ESRP1 mutations cause hearing loss Alex Rohacek, a graduate student in the Epstein lab, evaluated embryos in which Esrp1 was deleted in a mouse model developed by the Carstens lab.

This mouse model develops primary mammary tumors that spontaneously metastasize to the lung (Guy et al., 1992; Lin et al., 2003).

We offer quality custom generation of a wide range of mouse models developed by microinjection of Sv129 / Pas or C57BL / 6N ES cells into blastocysts or by DNA pronuclear injection.

Now, a research team at Imperial College London has found that in a mouse model developing liver cancer, one immunoreceptor — attractive candidate for immunotherapies — promoted rather than delayed tumour growth.

Not exact matches

Currently SQZ is developing its technology further using mouse models and human blood experiments to understand its mechanisms of action more fully.

«The successful restoration of normal function demonstrated in the mouse models suggests that if we can develop therapies to address the loss of Mecp2,» Baylor's Zoghbi says, «we may be able to reverse neurological damage in children and adults with Rett, autism and related neuropsychiatric disorders.»

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

Gandhi's research team is the first to develop a mouse model with depleted levels of a protein called augmenter of liver regeneration (ALR), which is essential for the survival of liver cells called hepatocytes.

So the researchers chose a mouse model that develops tau pathology and neuron loss — but no Aβ plaques.

Based primarily at Harvard with Maniatis, tenOever developed a knockout mouse model to study a particular protein, IKKε, that's involved in the immune response to viral infection.

For this study, Guttridge, first author David J. Wang, who developed many of the study's concepts, and their colleagues monitored NF - kB activity during tumor development using mouse embryonic fibroblasts and two mouse models.

Researchers used a mouse model to pinpoint exactly how HSCs develop in the womb.

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune system.

In the quest for an animal model of PD that mimics motor and non-motor symptoms of human PD, scientists have developed strains of mice that overexpress α - synuclein.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

In this study, the researchers performed a series of electrophysiological and behavioral experiments on a mouse model of schizophrenia developed at CUMC.

Most importantly, these cells protected mice from developing diabetes in a model of disease, having the critical ability to produce insulin in response to changes in glucose levels.

«We have developed a mouse genetic model of Dravet syndrome, which is allowing us to probe more deeply into the possible beneficial effects of cannabidiol,» Catterall said.

Unlike rodent models, which are developed from inbred strains of mice kept in controlled environments, companion animals, like humans, are genetically diverse and are exposed to many of the same environmental influences as their owners are.

Intriguingly, in the new study, the brains of mice modeling autism that were fed the high - glycemic index diet had drastically less doublecortin, a protein indicator of newly developing neurons, compared to predisposed mice on the low - glycemic index diet.

To gain new insights, Luther Bartelt of the University of North Carolina at Chapel Hill and colleagues developed a new laboratory mouse model of co-infection during malnutrition.

Scientists conducting a long - term research project at the University of Zurich were able to develop a mouse model.

The team has also developed a new mouse model that already carries the Cas9 protein.

If the mitochondria of both mothers are genetically very different, it may have the same effects seen in the mouse model,» says Burgstaller who developed the theory together with co-author Joanna Poulton, Professor of Mitochondrial Genetics at the John Radcliffe Hospital in Oxford.

Despite decades of effort, however, researchers were unable to develop a mouse model of renal cell carcinoma — until now.

Now, thanks to the new mouse model, it will be possible to study how renal tumors are able to develop in an environment with a normal immune system, and how cancer cells manage to evade the immune system's attacks.

The new mouse model will make it possible to develop better therapies for renal cancer.

«This model supported cancer development so strongly that some mice developed invasive squamous cell skin cancers similar to the patient's tumor,» said lead author Shadmehr Demehri, MD, PhD, a dermatologist and postdoctoral fellow.

The mouse model is available immediately for testing of antivirals, and Weaver said that preliminary testing is already underway with an antiviral developed by another member of the UTMB team, Pei - Yong Shi, PhD, to treat dengue fever.

To understand this spread, the Penn researchers developed a mouse model that uses multiple fluorescent proteins to tag and track different pancreatic cancer cells as they enter the bloodstream and spread to distant organs.

He returned to St. Louis and shifted several members of his lab to studying Zika, including developing mouse models of the disease.

The mice described in the current report were developed for testing of drug and vaccine candidates and may not be good models for human transmission, said Weaver.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

Last year, Diamond and others developed a mouse model of Zika infection that mimics the effects of the infection in pregnant women.

In any case, model strains of monkeys à la transgenic mice could be developed only if the added human gene is passed along to offspring — and that will remain an open question for some time.

Recently, Dr. Cohen's laboratory obtained an ethical approval to test the therapeutic efficiency of NT219 as a treatment in Alzheimer's - model mice, hoping to develop a future treatment for hitherto incurable neurodegenerative disorders.

«Usually, when researchers want a mouse or other animal model to express fluorescent proteins in certain cells, they need to develop genetically modified animals that can take months to years to make and characterize,» says former graduate student and first author Ken Chan (PhD» 17).

To corroborate the findings, the researchers also developed a novel mouse model that was deficient for autophagy specifically in beta cells with expression of the human form of islet amyloid polypeptide.

As they develop human clinical trials, Wargo and colleagues also are conducting lab and mouse model research to better understand the mechanisms that connect bacteria and the immune system.

The Vanderbilt researchers currently are developing a mouse model to confirm these findings, and they are working with biopharmaceutical firms to develop more effective treatments for ASD that specifically target the dopamine transporter, he said.

National Institutes of Health (NIH) scientists have developed a mouse model to study Zika virus transmitted sexually from males to females, as well as vertically from a pregnant female to her fetus.

One of the new patents was granted to Philip Leder and William Muller at Harvard University for a transgenic mouse that serves as a model for men who develop enlarged prostate glands.

MERS and SARS: The pause includes three grants and two contracts that are attempting to develop a strain of the MERS coronavirus that sickens mice so that researchers will have an animal model for testing MERS drugs and vaccines.

Among the susceptible mice, eating or drinking emulsifiers for 12 weeks increased the risk of developing symptoms of colitis — a mouse model of the intestinal inflammation seen in humans with IBD — from 40 % to 80 %.

Kanta Subbarao of the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, said her group has had to stop its efforts to adapt the MERS virus to mice to develop an animal model for the disease.

The discovery was made by developing a mouse model of the disease that enabled researchers to track which of 15 genetic groups — or subclones — of myeloma cells spread beyond their initial site in the animals» hind legs.