Sentences with phrase «mouse model development»

You can apply for the INFRAFRONTIER2020 mouse model development service to deliver novel mouse lines.

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Capsaicin additionally produced a significant deceleration of the development of prostate tumors created simply by those human cell lines grown in mouse models.

«The mouse is a particularly suitable model in which to study the development of the auditory system, because newborn mice are deaf and only begin to perceive acoustic signals at 12 days after birth.

PDX models are created by implanting cancerous tissue from a human primary tumor directly into immunodeficient mouse or rat models, enabling acceleration of oncology research or drug discovery and development programs.

Prof. Marine and his team generated a refined mouse model that faithfully reproduces the early stages of melanoma development in humans.

This study identifies myomerger as a fundmentally required protein for muscle development using cell culture and laboratory mouse models.

For this study, Guttridge, first author David J. Wang, who developed many of the study's concepts, and their colleagues monitored NF - kB activity during tumor development using mouse embryonic fibroblasts and two mouse models.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

In a mouse model in which they simulated the development of CML by adding Bcr - Abl to the bone marrow, a shortage of Gab2 led to a clear weakening or even a lack of symptoms.

The most pivotal of those experiments involved the development of a novel «knock - in» mouse model in which a point mutation was introduced in GRK2 to prevent NO from binding (a process called nitrosylation).

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

To study the relationship between autism and subplate neuron development in mice, Kanold, Nagode and their collaborators began with a well - established mouse model of autism.

«The next steps are to fully define the role of the interferon response in the development of Down syndrome using mouse models.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

Using CRISPR / Cas9, the Hamon Center team was able to correct the genetic defect in a mouse model of DMD and thus prevent the development of features of the disease, which in boys causes progressive muscle weakness and degeneration, often along with breathing and heart complications.

The mouse model could also contribute to the further development of immunotherapies — a method in which the body's immune system is stimulated, so that it intensifies its fight against tumor cells.

Studies in the mouse model further suggest that controlled expression of Lin28 can promote kidney development and therefore may hold clues to regeneration of damaged kidneys in adults.

The prevention of dilated cardiomyopathy in a mouse model by feeding a high - fat diet signals an advance in the understanding of the mechanisms involved in heart disease and has implications for the future development of treatments for this condition.

«The goal of our study, which we carried out using a mouse model of obese pregnancy, was to determine whether a novel antioxidant given to mothers during pregnancy and breastfeeding could prevent the development of NAFLD in the offspring.»

Terbinafine, a U.S. Food and Drug Administration — approved antifungal drug targeting SQLE, markedly inhibited SQLE - induced NAFLD - HCC cell growth in NAFLD - HCC and HCC cells and attenuated tumor development in xenograft models and in Sqle transgenic mice.

«This model supported cancer development so strongly that some mice developed invasive squamous cell skin cancers similar to the patient's tumor,» said lead author Shadmehr Demehri, MD, PhD, a dermatologist and postdoctoral fellow.

The researchers showed in mouse models that chronic skin inflammation caused by continuous skin contact with allergens contributes to tumor development.

Burd and colleagues previously reported in Cancer Discovery, a journal of the AACR, the development of this mouse melanoma model.

Indeed, exposure of the protein produced by the nanoparticle - based gene therapy to the gut mucosa prevents inhibitor development and restores clotting - factor activity in mouse models of both haemophilia A and B. «This approach really could hold big benefit for patients,» says Jörg Schüttrumpf, a transfusion - medicine specialist who led one of the studies performed at the German Red Cross Blood Donor Service in Frankfurt.

Recently, teaming up with co-investigator Associate Professor Dr. Rolf A. Brekken, they looked into its possible involvement in Pancreatic Ductal Adenocarcinoma (PDA), the most common form of pancreatic cancer, in a mouse model with an early onset aggressive form of tumor development.

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

In an experimental model of malaria in pregnancy, supplementing the diet of pregnant mice with L - arginine increased blood vessel development in the placenta and reduced low birth weight / preterm birth and stillbirth.

In his current position at The Jackson Laboratory, he has overall responsibility for the ongoing operational development of the PDX resource, which generates, banks, and distributes patient - derived xenograft (PDX) mouse models of human cancers.

With the help of various mouse models for pancreatic cancer, they have succeeded in elucidating the molecular pathways of tumor development in detail and have gained a better understanding of how various characteristics of the disease arise.

In experiments with cancer cell lines, the PIM1 inhibitors killed cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regression.

«Observing the changes in the architecture of islets during embryonic development in mice and in pseudoislets — a model we generated in our lab — was also very interesting.

Mice given alcohol just after birth are a good model for measuring the impact on human fetal development because the brains of mice pups achieve developmental milestones after birth that are comparable to those in other mammals, including humMice given alcohol just after birth are a good model for measuring the impact on human fetal development because the brains of mice pups achieve developmental milestones after birth that are comparable to those in other mammals, including hummice pups achieve developmental milestones after birth that are comparable to those in other mammals, including humans.

«Our goal was to characterize the development of brain circuits involved in appetite regulation, using a mouse model for Prader - Willi syndrome.

In a mouse model, tripling RCAN1 alone caused the loss of neurons and nerve growth; reducing the extra dose of RCAN1 improved survival of neurons and nerve development.

«In our study, we were able to demonstrate in mouse models that Fas is activated within the scope of obesity and can therefore lead to the development of liver steatosis,» says Prof. Dr. med.

Researchers from Massachusetts Eye and Ear / Harvard Medical School have identified inflammatory factors that cause optic neuropathy in the back of the eye following implantation of a keratoprosthesis (KPro)-- similar to what glaucoma patients experience, without the rise of pressure in the eye — and have shown that blocking one of those factors, tumor necrosis factor alpha (TNFa), successfully halts the development of optic nerve damage in a mouse model.

The new study is based on the development of mouse models manifesting the disease that causes megalencephaly, spasticity and ataxia in humans.

With use of advanced mouse models, she and her team found that blood stem cells without adequate SIRT1 resembled aged and defective stem cells, which are thought to be linked to development of malignancies.

The study of these new mouse models means an advance in the knowledge of disease's development mechanisms and an opportunity to implement new therapeutic strategies for patients.

Using a mouse model of cancer that provides direct microscopic access to lymph nodes, they first found that the initiation and growth of node metastases did not involve the development of new blood vessels.

Thus, in discovering that NK cells control ATMS and consequently inflammation, the Joslin scientists have identified a new mechanism in the development of obesity - induced insulin resistance in mouse models.

It is far more challenging to study brain development in people, so mice serve as a model for these studies.

«The current study investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved,» said co-author Lorenzo Cohen, Ph.D., professor of Palliative, Rehabilitation, and Integrative Medicine.

«Clearly this is a model for both human as well as mouse development.»

This is a very popular mouse model in cancer studies, and we hope our data will aid research into cancer development.»

While humanized mouse models for HIV infection have utility, the model is limited due to incomplete immune reconstitution, development of xenogeneic graft versus host disease (GVHD), and the absence of normal T cell homeostasis.

Pattwell studies the development of the brain, particularly the neural circuits associated with fear, anxiety, and post-traumatic stress disorder using mice as a model.

Because PD - L1 / programmed cell death (PD - 1) deficiency accelerates development of diabetes in mouse models, Nasr et al. hypothesized that a defect in the PD - L1 / PD - 1 pathway may underpin the hyperglycemia observed in the nonobese diabetic (NOD) mouse model.

«This study, done using a mouse model, expands our understanding of how associative fear memory for a relevant context is encoded in the brain,» said Cho, the lead author of the study and a member of the UCR School of Medicine's Center for Glial - Neuronal Interactions, «and could inform the development of novel therapeutics to reduce pathological fear in PTSD.»