Sentences with phrase «mouse model experiments»

Treating the potentially blinding haze of a scar on the cornea might be as straightforward as growing stem cells from a tiny biopsy of the patient's undamaged eye and then placing them on the injury site, according to mouse model experiments conducted by researchers at the University of Pittsburgh School of Medicine.

Not exact matches

Currently SQZ is developing its technology further using mouse models and human blood experiments to understand its mechanisms of action more fully.

In a series of experiments using mouse and rat models of depression reported today in Nature, Hu and her colleagues found that ketamine did affect the lateral habenula — but it was the pattern of firing, rather than the overall amount of activity, that proved crucial.

The most pivotal of those experiments involved the development of a novel «knock - in» mouse model in which a point mutation was introduced in GRK2 to prevent NO from binding (a process called nitrosylation).

Now Perry and Holmes have built up a detailed picture of how this happens through experiments in mice with prion disease, a model of neurodegeneration.

In this study, the researchers performed a series of electrophysiological and behavioral experiments on a mouse model of schizophrenia developed at CUMC.

Additional experiments also showed that TiY can suppress the tumor growth in mice xenograft model.

The first key experiment involved removing a specific subset of activated T - cells from mouse models.

To validate their computer modeling predictions, researchers performed experiments in human cancer cell lines, mouse liver samples and primary human hepatocytes.

Provide example data from experiments using PD - L1 positive tumors and a cancer cell - line engraftment into a humanized mouse model that was used to test anti-PD1 immune therapy

Experiments in mouse models of Parkinson's disease and amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease) have demonstrated that Nrf2 - based neural protection is primarily conferred by astrocytes, but how neurons might alert astrocytes to stressful conditions is poorly understood.

In experiments with cancer cell lines, the PIM1 inhibitors killed cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regression.

Taking this one step further, the researchers performed the same experiments in a mouse model of Alzheimer's disease to see if these astrocytic adenosine receptors were also involved in memory loss associated with the disease.

«We then compare the results obtained from the computer model with results of our collaborators doing more laborious experiments in rabbits, mice, or NHPs.

Their initial experiments found increased bone activity in two mouse models of a common form of lung cancer and in 70 lung cancer patients, even in absence of bone metastasis.

In another experiment, the researchers tested whether MMP - 9 has a functional role in ALS by crossing MMP - 9 knockout mice with SOD1 mutant mice (a standard mouse model of ALS).

He says, however, because they are small and easy to keep in captivity — unlike wild mice, which are notoriously difficult to maintain in cages — wall lizards would make a good model species for experiments designed to determine the effects of toxins on mortality, reproduction and growth.

Macaques can't be infected with Plasmodium falciparum, but when the researchers repeated the experiment in mice, using a mouse model of malaria, they found they could reach levels of protection between 71 % and 100 % using intravenous administration.

Their answer, garnered through a series of electrophysiology, dendritic spine density and immunohistochemistry experiments with mice that were genetically altered to produce either more new neurons or kill off newborn neurons, supports the second model — some of the cortical neurons transfer their connections from mature granule cells to the new granule cells.

On this week's show: Kelly Servick talks about how the microbiomes of model mice can change the outcomes of experiments, and a daily news roundup

He said experiments are under way to test the two - drug combination in laboratory models of metastasis - prone prostate cancer, leading eventually to tests in mouse models.

Visel says that Cohn's experiments with snake embryos «independently confirm what we saw in our mouse models.

This experiment examines the requirement of POSTN in metastatic colonization using the MMTV - PyMT mouse model.

2) The two repeated experiments analyze the source of POSTN expression in the lung and whether it affects the number / size of primary and secondary tumor formation in a spontaneous mouse model of breast cancer (MMTV - PyMT).

To rule out that the induction observed was due to other diabetic - associated alterations in the pancreas, we performed a control experiment in which we injected Tg - hIAPP mice with pancreas homogenate from a diabetic model not associated with IAPP aggregation.

To test that hypothesis, we performed ex vivo studies using isolated islets cultures and in vivo experiments in a transgenic (Tg) mouse model overexpressing hIAPP.

These models include in vitro experiments with purified recombinant or synthetic proteins, cell culture experiments, and infectivity studies with Tg mice expressing the appropriate form of the protein.

«We are now able to model human blood function in so - called «humanized mice»,» said George Daley, head of a research lab at Boston Children's Hospital and the main architect of the experiment, in a statement.

Scientists publish the results of roughly 100,000 experiments a year that had used rats or mice to «model» effects in people.

Replicating her experiments in T cell - competent mice confirmed that both mouse models mount a robust CD8 + T cell response to Zika infection.

For this study, Jabri and colleagues combined insights and data from celiac disease patients who had been cared for at the University of Chicago's Celiac Disease Center with experiments using a mouse model of the disease developed in her lab.

The researchers used several mouse models for muscular dystrophy, carrying out experiments in parallel.

They also plan to conduct similar experiments in a mouse model that more closely approximates what would happen in humans.

Now we are embarked on experiments that will show improvements in both healthspan and lifespan in model organisms from mice to primates.

Results obtained with human samples will be substantiated with experiments in mouse models, including models based on genetically modified mice.

This experiment was conducted to verify the findings in the initial experiment of a hypersensitivity immunopathologic - like reaction after SARS - CoV challenge of vaccinated animals, to determine if a higher dosage of the S protein vaccine (SV) would suppress infection and still exhibit a similar reaction, and whether the original β propiolactone inactivated whole virus vaccine (BPV) that had shown an immunopathologic - like reaction after challenge of vaccinated ferrets and nonhuman primates exhibited a similar immunopathologic reaction in the mouse model [13], [14].

My research goal is to improve a mouse model of this disease by introducing pro-inflammatory cues, and to experiment with a method of decreasing inflammation in the eye to test the idea that localized control of inflammation could help protect vision.

In the first set of experiments, we will cause a mild inflammation in this mouse model.

An innovative experiment validates a mouse model for studying therapies that may close the gap between life span and health...

These experiments are innovative because they seek to improve a mouse model based on current knowledge from human disease, while also testing novel therapies that could be of benefit for affected individuals.

Cell tracking and manipulation in genetically modified mice 2015-03-31 Presentation 06 Fafilek Mouse transgenic model to study tumor progression and metastasis in the gut 2015-03-24 Presentation 05 Krausova Next generation sequencing: designing experiment in transgenic

This unique international event will provide the attendees with an innovative program focused on the best practices in the use of the mouse model for biomedical and basic research; this program also addresses the item of continuing professional education consistent with the new European directive requirement for lab animal protection in experiments.

Gardiner says her group is now looking at data from a similar experiment done with a mouse model of Down syndrome.

The Joslin scientists next experimented with mouse models in which blood clots were induced in the brain and then treated with tPA.

The dual appointment allows him to conduct experiments that compare genetic programming in the highly regenerative animals used as models at the MDI Biological Laboratory with genetic programming in neonatal and adult mice.

Exemplifying the useful symbiosis of animal experiments and computer modeling, the paper describes the quest to understand the interplay between genetic patterns and physiological traits that contribute to weight in mice.

The goal of this project, therefore, is to clarify, through a series of experiments in cellular and mouse models, the role of Hippo signaling in HD.

These and countless other experiments in mouse and human models have firmly established the role of the microbiome in energy homeostasis.